https://m2.mtmt.hu/ hun 2026-06-06 19:11 JournalArticle 32866658 VALIDATED true Department of Rheumatology & Clinical Immunology, Department of Internal Medicine & Oncology, Hungary Department of Genetics, Cell & Immunobiology, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Rheumatology, BAZ County Central Hospital, Miskolc, Hungary Department of Rheumatology, Csolnoky Ferenc Hospital, Veszprém, Hungary Department of Rheumatology, Békés County Central Hospital, Gyula, Hungary Department of Rheumatology, Fejér County Saint George Hospital, Székesfehérvár, Hungary Department of Rheumatology & Immunology, University of Pécs Clinical Centre, Pécs, Hungary Department of Internal Medicine, Rheumatology, University of Debrecen Clinical Centre, Debrecen, Hungary Roche (Hungary) Ltd, Budapest, Hungary Rheumatology & Immunology Clinic, University of Szeged Clinical Centre, Szeged, Hungary Cited By :1 Export Date: 22 June 2024 Correspondence Address: Nagy, G.; Department of Rheumatology & Clinical Immunology, Árpád fejedelem útja 7, Hungary; email: nagy.gyorgy2@med.semmelweis-univ.hu Chemicals/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; aspartate aminotransferase, 9000-97-9; C reactive protein, 9007-41-4; cholesterol, 57-88-5; gamma glutamyltransferase, 85876-02-4; methotrexate, 15475-56-6, 59-05-2, 7413-34-5, 7532-09-4, 6745-93-3, 51865-79-3, 60388-53-6; tocilizumab, 375823-41-9 0 false 2026-05-21T22:51:47.458+0000 2023-10-19T07:08:43.819+0000 2022-06-07T11:14:09.112+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-05-14T11:22:05.889+0000 2026-05-14T11:22:05.889+0000 2023-09-02T13:58:07.343+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:21:58.800+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nagy, György Real-world evidence on methotrexate-free subcutaneous tocilizumab therapy in patients with rheumatoid arthritis : 24-week data from the SIMPACT study true true /api/journal/20076352 REVIEWED true false false 20076352 true 2514-1775 Journal FOREIGN 6 2 rkac038 rkac038 13 2022 The aim of the SIMPACT study was to evaluate the efficacy and safety of MTX-free s.c. tocilizumab (TCZ) therapy in RA patients.SIMPACT was an open-label, non-controlled, non-randomized, non-interventional study, in which RA patients for whom the treating physicians ordered s.c. TCZ were observed during a 24-week treatment period in Hungarian centres. Although the use of MTX was avoided during the study period, other conventional synthetic DMARDs, oral CSs and NSAIDs were allowed. Study endpoints included the change in DAS28 and clinical activity index (CDAI) scores, the proportion of patients achieving remission in the whole population and in subgroups defined based on prior RA treatment history, and age, weight or biological sex post hoc. The extent of supplementary medication use was monitored.Three hundred and thirty-seven RA patients were enrolled in 18 study centres. TCZ therapy significantly decreased the disease activity measured by both DAS28 (P = 0.0001) and CDAI (P = 0.0001). Clinical response was more pronounced in biologic-naïve patients and was lower in patients >75 years of age. In the whole population, DAS28 ESR or CRP and CDAI remission rates were 70.10%, 78.95% and 33.59%, respectively. In patients <45 years of age, the CDAI remission rate doubled (67.86%). A significant decrease in the frequency of co-administered medication was reported, including oral CSs and DMARDs.Real-world clinical evidence on s.c. TCZ reported here is in line with the efficacy outcomes of randomized clinical trials. Subgroup analysis revealed that TCZ was more effective in biologic-naïve patients and in those <75 years old.ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT02402686. true 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.1093/rap/rkac038 4 0 4 4 1 4 4 2 2 2 2 2 2 4 0 0 4 4 4 4 0 3 3 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 0 0 0 0 2025 0 2 2 2 2 2026 0 1 1 1 1 Q2 false false false false 2022-06-06T11:29:38.845+0000 Belgyógyászati Intézet (DE / ÁOK); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Reumatológia (FVSZGYEOK); Reumatológiai Tanszék (DE / ÁOK / BelgyI); Reumatológiai és Immunológiai Klinika (PTE / ÁOK); Reumatológiai és Immunológiai Klinika (SZTE / SZAOK); Reumatológiai és Klinikai Immunológiai Tanszék (SE / AOK / K / BOK) 7 57 8 10 0 true 10097590 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 101949304 /api/authorship/101949304 1 0.1 true false true Author 10025749 /api/author/10025749 Nagy György true 10025749 true Nagy György true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949305 /api/authorship/101949305 2 0.1 false false false Author 10004870 /api/author/10004870 Géher Pál true 10004870 true Géher Pál true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949306 /api/authorship/101949306 3 0.1 false false false Tamási László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949307 /api/authorship/101949307 4 0.1 false false false Drescher Edit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949308 /api/authorship/101949308 5 0.1 false false false Keszthelyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949309 /api/authorship/101949309 6 0.1 false false false Author 10072566 /api/author/10072566 Pulai Judit true true Pulai Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949310 /api/authorship/101949310 7 0.1 false false false Author 10000307 /api/author/10000307 Czirják László true 10000307 true Czirják László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949311 /api/authorship/101949311 8 0.1 false false false Author 10003464 /api/author/10003464 Szekanecz Zoltán true 10003464 true Szekanecz Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949312 /api/authorship/101949312 9 0.1 false false false Author 10021833 /api/author/10021833 Kiss Gergely true 10021833 true Kiss Gergely true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101949313 /api/authorship/101949313 10 0.1 false true false Author 10000086 /api/author/10000086 Kovács László true 10000086 true Kovács László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21102904 /api/publicationidentifier/21102904 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1093/rap/rkac038 https://doi.org/10.1093/rap/rkac038 false true PublicationIdentifier 21180381 /api/publicationidentifier/21180381 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000804412400003 https://www.webofscience.com/wos/woscc/full-record/000804412400003 true true PublicationIdentifier 21257517 /api/publicationidentifier/21257517 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85132970430 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132970430 false true PublicationIdentifier 21102903 /api/publicationidentifier/21102903 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35663154 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35663154&dopt=Abstract false true PublicationIdentifier 21475954 /api/publicationidentifier/21475954 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://academic.oup.com/rheumap/advance-article/doi/10.1093/rap/rkac038/6586319 https://academic.oup.com/rheumap/advance-article/doi/10.1093/rap/rkac038/6586319 false true PublicationIdentifier 21110122 /api/publicationidentifier/21110122 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 24509 http://publicatio.bibl.u-szeged.hu/24509 false true Classification 12215 /api/classification/12215 true true Classification 12124 /api/classification/12124 true true Classification 12282 /api/classification/12282 true true Keyword 4587 /api/keyword/4587 true 4587 true Keyword 20167 /api/keyword/20167 true 20167 true Keyword 1012002 /api/keyword/1012002 true 1012002 true Keyword 1109423 /api/keyword/1109423 true 1109423 true Keyword 1329178 /api/keyword/1329178 true 1329178 true Keyword 1493462 /api/keyword/1493462 true true Keyword 2643433 /api/keyword/2643433 true true SjrRating 11318777 /api/sjrrating/11318777 28 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2745 /api/classificationexternal/2745 true 2745 true Q2 DIRECT true true /api/publication/32866658 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy György ✉ (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004870"><a href="/gui2/?type=authors&mode=browse&sel=10004870" target="_blank">Géher Pál (<span class="authorship-author-name">Géher Pál</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tamási László </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Drescher Edit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Keszthelyi Péter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072566"><a href="/gui2/?type=authors&mode=browse&sel=10072566" target="_blank">Pulai Judit (<span class="authorship-author-name">Pulai Judit</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Fejér Megyei Szent György Egyetemi Oktató Kórház">FMSZGYEOK</span>/Reumatológia</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000307"><a href="/gui2/?type=authors&mode=browse&sel=10000307" target="_blank">Czirják László (<span class="authorship-author-name">Czirják László</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Reumatológiai és Immunológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003464"><a href="/gui2/?type=authors&mode=browse&sel=10003464" target="_blank">Szekanecz Zoltán (<span class="authorship-author-name">Szekanecz Zoltán</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Reumatológiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Belgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021833"><a href="/gui2/?type=authors&mode=browse&sel=10021833" target="_blank">Kiss Gergely (<span class="authorship-author-name">Kiss Gergely</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000086"><a href="/gui2/?type=authors&mode=browse&sel=10000086" target="_blank">Kovács László (<span class="authorship-author-name">Kovács László</span> <span class="authorAux-mtmt"> belgyógyászat, reumatológia, immunológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Reumatológiai és Immunológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32866658" target="_blank">Real-world evidence on methotrexate-free subcutaneous tocilizumab therapy in patients with rheumatoid arthritis : 24-week data from the SIMPACT study</a></div> <div> <span class="journal-title">RHEUMATOLOGY ADVANCES IN PRACTICE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2514-1775">2514-1775</a>)</span>: <span class="journal-volume">6</span> <span class="journal-issue">2</span> <span class="page"> Paper rkac038. 13 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/rap/rkac038" target="_blank" href="https://doi.org/10.1093/rap/rkac038"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000804412400003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000804412400003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85132970430" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132970430"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35663154" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35663154&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://academic.oup.com/rheumap/advance-article/doi/10.1093/rap/rkac038/6586319" target="_blank" href="https://academic.oup.com/rheumap/advance-article/doi/10.1093/rap/rkac038/6586319"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="24509" target="_blank" href="http://publicatio.bibl.u-szeged.hu/24509"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Rheumatology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32866658&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32866658</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2023.10.19. 09:08 Szemenyeiné Rideg Ágnes (FM Szent György Kórház admin4) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:21 Ladányi Gusztáv (MTMT API user, admin) Orbán Zsófia (MTMT ellenőrzés, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Rheumatology & Clinical Immunology, Department of Internal Medicine & Oncology, Hungary Department of Genetics, Cell & Immunobiology, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Rheumatology, BAZ County Central Hospital, Miskolc, Hungary Dep...</pre> </div></div>