https://m2.mtmt.hu/ hun 2026-05-30 13:18 JournalArticle 32866401 VALIDATED true Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, Debrecen, 4028, Hungary Department of Applied Mathematics and Probability Theory, Faculty of Informatics, University of Debrecen, Debrecen, 4032, Hungary Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary Materials Science Laboratory, Institute for Nuclear Research, Debrecen, 4001, Hungary Department of Periodontology, Faculty of Dentistry, University of Debrecen, Debrecen, 4028, Hungary Department of Periodontology, School of Dental Medicine, University of Bern, Bern, 3010, Switzerland University Pharmacy Department of Pharmacy Administration, Faculty of Pharmaceutical Sciences, Semmelweis University, Budapest, 1085, Hungary Export Date: 4 January 2023 Correspondence Address: Hegedus, C.; Department of Biomaterials and Prosthetic Dentistry, Hungary; email: hegedus.csaba.prof@dental.unideb.hu 0 false 2026-05-21T22:50:54.738+0000 2025-04-16T08:17:41.112+0000 2022-06-07T09:30:09.612+0000 true 10066331 Vida Zsuzsa Ágnes /api/admin/10066331 Admin Vida Zsuzsa Ágnes (DE/ÁOK/ElettI Admin 5, admin) true 2026-02-23T09:13:08.809+0000 2026-02-23T09:13:08.809+0000 2025-04-16T08:17:41.321+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Bako, Jozsef true true /api/journal/10022148 REVIEWED PHARMACEUTICS 1999-4923 true false 10022148 false 10022148 true 1999-4923 Journal FOREIGN 14 5 957 957 19 2022 The in situ application of the combination of different types of drugs revolutionized the area of periodontal therapy. The purpose of this study was to develop nanocomposite hydrogel (NCHG) as a pH-sensitive drug delivery system. To achieve local applicability of the NCHG in dental practice, routinely used blue-light photopolymerization was chosen for preparation. The setting time was 60 s, which resulted in stable hydrogel structures. Universal Britton-Robinson buffer solutions were used to investigate the effect of pH in the range 4-12 on the release of drugs that can be used in the periodontal pocket. Metronidazole was released from the NCHGs within 12 h, but chlorhexidine showed a much longer elution time with strong pH dependence, which lasted more than 7 days as it was corroborated by the bactericidal effect. The biocompatibility of the NCHGs was proven by Alamar-blue test and the effectiveness of drug release in the acidic medium was also demonstrated. This fast photo-polymerizable NCHG can help to establish a locally applicable combined drug delivery system which can be loaded with the required amount of medicines and can reduce the side effects of the systemic use of drugs that have to be used in high doses to reach an ideal concentration locally. Funding 2014848 /api/funding/2014848 (TKP2021-EGA-20) Támogató: NKFIH false true Funding 2014849 /api/funding/2014849 (TKP2021-EGA) false true Funding 2014850 /api/funding/2014850 (TKP2021-NKTA-42) false true Funding 2026217 /api/funding/2026217 (TKP2020-NKA-04) false true true INTERNATIONAL 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.3390/pharmaceutics14050957 26 0 25 25 1 25 25 22 23 23 23 23 23 26 0 0 26 26 25 25 0 3 3 Folyóiratcikk Journal Article 24 24 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 6 6 6 6 2024 0 6 6 6 6 2025 0 10 10 10 10 2026 0 3 3 3 3 Q1 false 10001151,10001402 false false false 2022-06-12T09:06:33.920+0000 Alkalmazott Matematika és Valószínűségszámítás ... (DE / IK); Atommagkutató Intézet; Bioanyagtani és Fogpótlástani nem önálló Tanszék (DE / FOK); Egyetemi Gyógyszertár Gyógyszerügyi Szervezési ... (SE / GYTK); Orvosi Mikrobiológiai Intézet (DE / ÁOK); Parodontológiai nem önálló Tanszék (DE / FOK) 8 34 6 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 101491875 /api/authorship/101491875 Bako, Jozsef [Bakó, József (fogászati polimer...), szerző] Bioanyagtani és Fogpótlástani nem önálló Tanszék (DE / FOK) 1 0.111 true false false Author 10036858 /api/author/10036858 Bakó József (fogászati polimerek, hatóanyagleadás, anyagtan) Bakó József true 10036858 true Bako Jozsef true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101491876 /api/authorship/101491876 Toth, Ferenc [Tóth, Ferenc (molekuláris biológia), szerző] Bioanyagtani és Fogpótlástani nem önálló Tanszék (DE / FOK) 2 0.111 false false false Author 10060158 /api/author/10060158 Tóth Ferenc (molekuláris biológia) Tóth Ferenc true 10060158 true Toth Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101491877 /api/authorship/101491877 Gall, Jozsef [Gáll, József Mihály (Pénzügyi matematika), szerző] Alkalmazott Matematika és Valószínűségszámítás ... (DE / IK) 3 0.111 false false false Author 10001402 /api/author/10001402 Gáll József Mihály (Pénzügyi matematika) Gáll József Mihály true 10001402 true Gall Jozsef true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101491878 /api/authorship/101491878 Kovacs, Renato [Kovács, Renátó (orvosi mikrobiológia), szerző] Orvosi Mikrobiológiai Intézet (DE / ÁOK) 4 0.111 false false false Author 10036819 /api/author/10036819 Kovács Renátó (orvosi mikrobiológia) Kovács Renátó true 10036819 true Kovacs Renato true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101951413 /api/authorship/101951413 Csík, Attila [Csík, Attila (Vákuumfizika), szerző] Atommagkutató Intézet 5 0.111 false false false Author 10001151 /api/author/10001151 Csík Attila (Vákuumfizika) Csík Attila true 10001151 true Csík Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101491880 /api/authorship/101491880 Varga, Istvan [Varga, István (Parodontológia), szerző] Parodontológiai nem önálló Tanszék (DE / FOK) 6 0.111 false false false Author 10051413 /api/author/10051413 Varga István (Parodontológia) Varga István true 10051413 true Varga Istvan true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101491881 /api/authorship/101491881 Sculean, Anton 7 0.11111111 false false false Sculean Anton true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101491882 /api/authorship/101491882 Zelko, Romana [Zelkó, Romána (Gyógyszertechnológia), szerző] Egyetemi Gyógyszertár Gyógyszerügyi Szervezési ... (SE / GYTK) 8 0.111 false false false Author 10002587 /api/author/10002587 Zelkó Romána (Gyógyszertechnológia) Zelkó Romána true 10002587 true Zelko Romana true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101491883 /api/authorship/101491883 Hegedus, Csaba ✉ [Hegedűs, Csaba (sztomatológia, fo...), szerző] Bioanyagtani és Fogpótlástani nem önálló Tanszék (DE / FOK) 9 0.111 false true true Author 10037880 /api/author/10037880 Hegedűs Csaba (sztomatológia, fogpótlástan, fogászati anyagtan) Hegedűs Csaba true 10037880 true Hegedus Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 21102166 /api/publicationidentifier/21102166 DOI: 10.3390/pharmaceutics14050957 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/pharmaceutics14050957 https://doi.org/10.3390/pharmaceutics14050957 false true PublicationIdentifier 21102167 /api/publicationidentifier/21102167 WoS: 000801438000001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000801438000001 https://www.webofscience.com/wos/woscc/full-record/000801438000001 false true PublicationIdentifier 21558123 /api/publicationidentifier/21558123 Scopus: 85131018735 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85131018735 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85131018735 true true PublicationIdentifier 21120463 /api/publicationidentifier/21120463 PubMed: 35631542 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35631542 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35631542&dopt=Abstract true true Classification 12197 /api/classification/12197 Gyógyszerészet, farmakogenomika, gyógyszerkutatás és tervezés, gyógyszeres kezelés true true Keyword 4591 /api/keyword/4591 Therapy true 4591 true Keyword 8303 /api/keyword/8303 DISEASES true 8303 true Keyword 19666 /api/keyword/19666 metronidazole true 19666 true Keyword 19666 /api/keyword/19666 metronidazole true 19666 true Keyword 1007221 /api/keyword/1007221 NANOCOMPOSITE true 1007221 true Keyword 1012989 /api/keyword/1012989 hydrogel true 1012989 true Keyword 1012991 /api/keyword/1012991 chlorhexidine true 1012991 true Keyword 1012991 /api/keyword/1012991 chlorhexidine true 1012991 true Keyword 1030354 /api/keyword/1030354 photopolymerization true 1030354 true Keyword 1518672 /api/keyword/1518672 DELIVERY-SYSTEM true true Keyword 2643343 /api/keyword/2643343 combined drug delivery true true SjrRating 11321229 /api/sjrrating/11321229 sjr:Q1 (2022) Scopus - Pharmaceutical Science PHARMACEUTICS 1999-4923 1999-4923 34 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 Scopus - Pharmaceutical Science true 3003 true Q1 DIRECT true true Reference 31389632 /api/reference/31389632 1. 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(2022) PHARMACEUTICS 1999-4923 14 5<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10036858"><a href="/gui2/?type=authors&mode=browse&sel=10036858" target="_blank">Bako Jozsef (<span class="authorship-author-name">Bakó József</span> <span class="authorAux-mtmt"> fogászati polimerek, hatóanyagleadás, anyagtan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Bioanyagtani és Fogpótlástani nem önálló Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060158"><a href="/gui2/?type=authors&mode=browse&sel=10060158" target="_blank">Toth Ferenc (<span class="authorship-author-name">Tóth Ferenc</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Bioanyagtani és Fogpótlástani nem önálló Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001402"><a href="/gui2/?type=authors&mode=browse&sel=10001402" target="_blank">Gall Jozsef (<span class="authorship-author-name">Gáll József Mihály</span> <span class="authorAux-mtmt"> Pénzügyi matematika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Informatikai Kar">IK</span>/Alkalmazott Matematika és Valószínűségszámítás Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036819"><a href="/gui2/?type=authors&mode=browse&sel=10036819" target="_blank">Kovacs Renato (<span class="authorship-author-name">Kovács Renátó</span> <span class="authorAux-mtmt"> orvosi mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001151"><a href="/gui2/?type=authors&mode=browse&sel=10001151" target="_blank">Csík Attila (<span class="authorship-author-name">Csík Attila</span> <span class="authorAux-mtmt"> Vákuumfizika</span>) </a> </span> <span class="author-affil">Atommagkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051413"><a href="/gui2/?type=authors&mode=browse&sel=10051413" target="_blank">Varga Istvan (<span class="authorship-author-name">Varga István</span> <span class="authorAux-mtmt"> Parodontológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Parodontológiai nem önálló Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sculean Anton </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002587"><a href="/gui2/?type=authors&mode=browse&sel=10002587" target="_blank">Zelko Romana (<span class="authorship-author-name">Zelkó Romána</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037880"><a href="/gui2/?type=authors&mode=browse&sel=10037880" target="_blank">Hegedus Csaba ✉ (<span class="authorship-author-name">Hegedűs Csaba</span> <span class="authorAux-mtmt"> sztomatológia, fogpótlástan, fogászati anyagtan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Bioanyagtani és Fogpótlástani nem önálló Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32866401" target="_blank">Combined Release of Antiseptic and Antibiotic Drugs from Visible Light Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment</a></div> <div> <span class="journal-title">PHARMACEUTICS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4923">1999-4923</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">5</span> <span class="page"> Paper 957. 19 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/pharmaceutics14050957" target="_blank" href="https://doi.org/10.3390/pharmaceutics14050957"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000801438000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000801438000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85131018735" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85131018735"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35631542" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35631542&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 26</span> | Független: 26 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 22 | Scopus jelölt:&nbsp;23 | WoS/Scopus jelölt:&nbsp;23 | DOI jelölt:&nbsp;25 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32866401&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32866401</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Bibtex</span> </div> <div class="funder"> (TKP2021-EGA-20) Támogató: NKFIH, (TKP2021-EGA), (TKP2021-NKTA-42), (TKP2020-NKA-04) </div> <div class="lastModified">Utolsó módosítás: 2025.04.16. 10:17 Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, Debrecen, 4028, Hungary Department of Applied Mathematics and Probability Theory, Faculty of Informatics, University of Debrecen, Debrecen, 4032, Hungary Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, 4032,...</pre> </div></div>