Gyógyszerészet, farmakogenomika, gyógyszerkutatás és tervezés, gyógyszeres kezelés
The in situ application of the combination of different types of drugs revolutionized
the area of periodontal therapy. The purpose of this study was to develop nanocomposite
hydrogel (NCHG) as a pH-sensitive drug delivery system. To achieve local applicability
of the NCHG in dental practice, routinely used blue-light photopolymerization was
chosen for preparation. The setting time was 60 s, which resulted in stable hydrogel
structures. Universal Britton-Robinson buffer solutions were used to investigate the
effect of pH in the range 4-12 on the release of drugs that can be used in the periodontal
pocket. Metronidazole was released from the NCHGs within 12 h, but chlorhexidine showed
a much longer elution time with strong pH dependence, which lasted more than 7 days
as it was corroborated by the bactericidal effect. The biocompatibility of the NCHGs
was proven by Alamar-blue test and the effectiveness of drug release in the acidic
medium was also demonstrated. This fast photo-polymerizable NCHG can help to establish
a locally applicable combined drug delivery system which can be loaded with the required
amount of medicines and can reduce the side effects of the systemic use of drugs that
have to be used in high doses to reach an ideal concentration locally.
