https://m2.mtmt.hu/ hun 2026-04-05 11:22 JournalArticle 32864285 VALIDATED true Department of Anaesthesia and Intensive Care, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, United Kingdom College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia Department of Pharmacy, King Abdulaziz Medical City, Riyadh, Al Riyadh Province, Saudi Arabia College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia Department of Medicine, King Abdulaziz Medical City, Riyadh, Al Riyadh Province, Saudi Arabia Cited By :2 Export Date: 4 June 2022 Correspondence Address: Rajendram, R.; Department of Anaesthesia and Intensive Care, United Kingdom; email: rajkumar.rajendram@nhs.net Chemicals/CAS: bicarbonate, 144-55-8, 71-52-3; creatinine, 19230-81-0, 60-27-5; guaifenesin, 93-14-1; ipratropium bromide, 22254-24-6; ivabradine, 148849-67-6, 148870-80-8, 155974-00-8; metoprolol tartrate, 56392-17-7; salbutamol, 18559-94-9, 35763-26-9; metoprolol, 37350-58-6; Anti-Arrhythmia Agents; Cardiovascular Agents; Ivabradine; Metoprolol 0 false 2025-07-30T15:15:00.510+0000 2022-06-04T14:26:26.878+0000 2022-06-04T11:37:03.790+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 2024-07-16T07:33:05.001+0000 2022-12-28T00:23:05.699+0000 true 10067876 Ladányi Gusztáv /api/admin/10067876 Admin Ladányi Gusztáv (MTMT API user, admin) true false false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Rajendram, R. true true /api/journal/10016301 REVIEWED BMJ CASE REPORTS 1757-790X true false 10016301 false 10016301 true 1757-790X Journal FOREIGN 13 1 230647 230647 2020 Muscular dystrophies are a heterogeneous group of disorders that commonly involve cardiac and skeletal muscle. Comprehensive guidelines for the management of cardiac failure and arrhythmias are available. However, the studies from which their recommendations are derived did not include any patients with muscular dystrophy. Some medications (eg, betablockers) may have significant side effects in this cohort. In some situations the use of agents with unique mechanisms of action such as ivabradine (a 'funny' channel inhibitor) may be more appropriate. Use of ivabradine has not previously been reported in limb girdle muscular dystrophy (LGMD). We describe the course of a patient with LGMD type 2I, cardiomyopathy and inappropriate sinus tachycardia treated with ivabradine. As advances in respiratory support have improved the outcomes of patients with muscular dystrophy; the prognostic significance of cardiac disease has increased. Ivabradine is tolerated and may reduce symptoms, morbidity and mortality in this cohort. © BMJ Publishing Group Limited 2020. No commercial re-use. 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true 1038545 true Keyword 1040959 /api/keyword/1040959 outpatient true 1040959 true Keyword 1042249 /api/keyword/1042249 ipratropium bromide true 1042249 true Keyword 1042941 /api/keyword/1042941 metoprolol tartrate true 1042941 true Keyword 1053763 /api/keyword/1053763 heart left ventricle ejection fraction true 1053763 true Keyword 1053879 /api/keyword/1053879 weakness true 1053879 true Keyword 1066551 /api/keyword/1066551 neuromuscular disease true 1066551 true Keyword 1076067 /api/keyword/1076067 cardiovascular agent true 1076067 true Keyword 1076070 /api/keyword/1076070 Anti-Arrhythmia Agents true 1076070 true Keyword 1076071 /api/keyword/1076071 antiarrhythmic agent true 1076071 true Keyword 1081484 /api/keyword/1081484 supraventricular tachycardia true 1081484 true Keyword 1083506 /api/keyword/1083506 Cardiovascular Agents true 1083506 true Keyword 1092060 /api/keyword/1092060 Ivabradine true 1092060 true Keyword 1092060 /api/keyword/1092060 Ivabradine true 1092060 true Keyword 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/api/keyword/1820836 limb girdle muscular dystrophy true true Keyword 1940991 /api/keyword/1940991 assisted ventilation true true Keyword 1962684 /api/keyword/1962684 lung angiography true true Keyword 1972551 /api/keyword/1972551 Tachycardia, Sinus true true Keyword 2642776 /api/keyword/2642776 fukutin related protein true true Keyword 2642777 /api/keyword/2642777 FKRP gene true true Keyword 2642778 /api/keyword/2642778 mucolysis true true Keyword 2642779 /api/keyword/2642779 sinoatrial nodal reentry tachycardia true true SjrRating 10995935 /api/sjrrating/10995935 sjr:Q4 (2020) Scopus - Medicine (miscellaneous) BMJ CASE REPORTS 1757-790X 1828 1.0 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q4 DIRECT true true Reference 31333321 /api/reference/31333321 1. Ptaszynski, P., Kaczmarek, K., Ruta, J., Ivabradine in combination with metoprolol succinate in the treatment of inappropriate sinus tachycardia (2013) J Cardiovasc Pharmacol Ther, 18, pp. 338-344 1 false true Reference 31333320 /api/reference/31333320 2. Ptaszynski, P., Kaczmarek, K., Ruta, J., Metoprolol succinate vs. ivabradine in the treatment of inappropriate sinus tachycardia in patients unresponsive to previous pharmacological therapy (2013) Europace, 15, pp. 116-121 2 false true Reference 31333319 /api/reference/31333319 3. Cappato, R., Castelvecchio, S., Ricci, C., Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: A prospective, randomized, placebo-controlled, double-blind, crossover evaluation (2012) J Am Coll Cardiol, 60, pp. 1323-1329 3 false true Reference 31333318 /api/reference/31333318 4. Swedberg, K., Komajda, M., Böhm, M., Ivabradine and outcomes in chronic heart failure (shift): A randomised placebo-controlled study (2010) Lancet, 376, pp. 875-885 4 false true Reference 31333317 /api/reference/31333317 5. Fox, K., Ford, I., Steg, P.G., Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (beautiful): A randomised, double-blind, placebo-controlled trial (2008) Lancet, 372, pp. 807-816 5 false true Reference 31333316 /api/reference/31333316 6. Koruth, J.S., Lala, A., Pinney, S., The clinical use of ivabradine (2017) J Am Coll Cardiol, 70, pp. 1777-1784 6 false true Reference 31333315 /api/reference/31333315 7. Poppe, M., Bourke, J., Eagle, M., Cardiac and respiratory failure in limb-girdle muscular dystrophy 2I (2004) Ann Neurol, 56, pp. 738-741 7 false true Reference 31333314 /api/reference/31333314 8. Walter, M.C., Petersen, J.A., Stucka, R., FKRP (826C>A) frequently causes limb-girdle muscular dystrophy in German patients (2004) J Med Genet, 41 8 false true Reference 31333313 /api/reference/31333313 9. Sveen, M.-L., Thune, J.J., Køber, L., Cardiac involvement in patients with limb-girdle muscular dystrophy type 2 and Becker muscular dystrophy (2008) Arch Neurol, 65, pp. 1196-1201 9 false true Reference 31333312 /api/reference/31333312 10. Kanagawa, M., Kobayashi, K., Tajiri, M., Identification of a post-translational modification with Ribitol-Phosphate and its defect in muscular dystrophy (2016) Cell Rep, 14, pp. 2209-2223 10 false true Reference 31333311 /api/reference/31333311 11. Bolduc, V., Marlow, G., Boycott, K.M., Recessive mutations in the putative calcium-activated chloride channel anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies (2010) Am J Hum Genet, 86, pp. 213-221 11 false true Reference 31333310 /api/reference/31333310 12. Guglieri, M., Straub, V., Bushby, K., Limb-Girdle muscular dystrophies (2008) Curr Opin Neurol, 21, pp. 576-584 12 false true Reference 31333309 /api/reference/31333309 13. De-Benedittis, G., Della-Rosa, G., D'Ettorre, E., Effect of ivabradine in dilated cardiomyopathy from Duchenne muscular dystrophy: A chance for slowing progression of heart failure? (2016) Int J Cardiol, 223, pp. 286-288 13 false true Reference 31333308 /api/reference/31333308 14. Finsterer, J., Stöllberger, C., Berger, E., Beneficial effect of ivabradine in dilated cardiomyopathy from Becker muscular dystrophy (2012) Herz, 37, pp. 702-705 14 false true Reference 31333307 /api/reference/31333307 15. Page, R.L., Joglar, J.A., Caldwell, M.A., 2015 ACC/AHA/HRS guideline for the management of adult patients with supraventricular tachycardia: A report of the American College of Cardiology/American Heart Association Task force on clinical practice guidelines and the heart rhythm Society (2016) Circulation, 133, pp. e506-e574 15 false true Reference 31333306 /api/reference/31333306 16. Ponikowski, P., Voors, A.A., Anker, S.D., 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC (2016) Eur J Heart Fail, 37, pp. 2129-2200 16 false true /api/publication/32864285 Rajendram R. et al. The use of ivabradine in a patient with inappropriate sinus tachycardia and cardiomyopathy due to limb girdle muscular dystrophy type 2I. (2020) BMJ CASE REPORTS 1757-790X 13 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Rajendram R. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Aldhahri F. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mahmood N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kharal M. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32864285" target="_blank">The use of ivabradine in a patient with inappropriate sinus tachycardia and cardiomyopathy due to limb girdle muscular dystrophy type 2I</a></div> <div> <span class="journal-title">BMJ CASE REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1757-790X">1757-790X</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">1</span> <span class="page"> Paper 230647. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1136/bcr-2019-230647" target="_blank" href="https://doi.org/10.1136/bcr-2019-230647"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000661528300012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000661528300012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85078243896" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85078243896"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31969397" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31969397&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32864285&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32864285</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2022.06.04. 16:26 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Anaesthesia and Intensive Care, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, United Kingdom College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia Department of Pharmacy, King Abdulaziz Medical City, Riyadh, Al Riyadh Province, Saudi Arabia College of Pharma...</pre> </div></div>