https://m2.mtmt.hu/ eng 2026-08-26 09:51 JournalArticle 32857208 VALIDATED true Funding Agency and Grant Number: AstraZeneca; British Heart Foundation Centre of Research Excellence [RE/18/6/34217] Funding text: Grant Support: The DAPA-HF trial was funded by AstraZeneca. Dr. McMurray was supported by British Heart Foundation Centre of Research Excellence Grant RE/18/6/34217. 0 false 2026-08-24T21:11:39.666+0000 2023-02-28T08:07:54.426+0000 2022-06-02T06:31:44.483+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2024-10-08T07:32:00.498+0000 2024-10-08T07:32:00.498+0000 2023-02-28T08:07:54.749+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Butt, Jawad H. Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction A Post Hoc Analysis of the DAPA-HF Trial true true /api/journal/355 REVIEWED true false 355 false 355 true 0003-4819 1539-3704 Journal FOREIGN 175 6 820 830 820 11 2022 Background: Frailty may modify the risk-benefit profile of certain treatments, and frail patients may have reduced tolerance to treatments. Objective: To investigate the efficacy of dapagliflozin according to frailty status, using the Rockwood cumulative deficit approach, in DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure). Design: Post hoc analysis of a phase 3 randomized clinical trial. (ClinicalTrials.gov: NCT03036124) Setting: 410 sites in 20 countries. Patients: Patients with symptomatic heart failure (HF) with a left ventricular ejection fraction of 40% or less and elevated natriuretic peptide. Intervention: Addition of once-daily 10 mg of dapagliflozin or placebo to guideline-recommended therapy. Measurements: The primary outcome was worsening HF or cardiovascular death. Results: Of the 4744 patients randomly assigned in DAPAHF, a frailty index (FI) was calculable in 4742. In total, 2392 patients (50.4%) were in FI class 1 (FI <= 0.210; not frail), 1606 (33.9%) in FI class 2 (FI 0.211 to 0.310; more frail), and 744 (15.7%) in FI class 3 (FI >= 0.311; most frail). The median follow-up time was 18.2 months. Dapagliflozin reduced the risk for worsening HF or cardiovascular death, regardless of FI class. The differences in event rate per 100 person-years for dapagliflozin versus placebo from lowest to highest FI class were-3.5 (95% CI,-5.7 to-1.2),-3.6 (CI,-6.6 to-0.5), and-7.9 (CI,-13.9 to-1.9). Consistent benefits were observed for other clinical events and health status, but the absolute reductions were generally larger in the most frail patients. Study drug discontinuation and serious adverse events were not more frequent with dapagliflozin than placebo, regardless of FI class. Limitation: Enrollment criteria precluded the inclusion of very high-risk patients. Conclusion: Dapagliflozin improved all outcomes examined, regardless of frailty status. However, the absolute reductions were larger in more frail patients. Primary Funding Source: AstraZeneca. Ann Intern Med. doi:10.7326/M21-4776 Annals.org For author, article, and disclosure information, see end of text. 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V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21077356 /api/publicationidentifier/21077356 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.7326/M21-4776 https://doi.org/10.7326/M21-4776 false true PublicationIdentifier 21077357 /api/publicationidentifier/21077357 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000795125100001 https://www.webofscience.com/wos/woscc/full-record/000795125100001 false true PublicationIdentifier 21242524 /api/publicationidentifier/21242524 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85132453939 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132453939 true true PublicationIdentifier 21077358 /api/publicationidentifier/21077358 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35467935 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35467935&dopt=Abstract false true Keyword 599 /api/keyword/599 true 599 true Keyword 4591 /api/keyword/4591 true 4591 true Keyword 9645 /api/keyword/9645 true 9645 true Keyword 11283 /api/keyword/11283 true 11283 true Keyword 1235012 /api/keyword/1235012 true 1235012 true SjrRating 11314073 /api/sjrrating/11314073 6 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2724 /api/classificationexternal/2724 true 2724 true D1 DIRECT true true /api/publication/32857208 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Butt Jawad H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dewan Pooja </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Bela (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Belohlavek Jan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Drozdz Jaroslaw </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kitakaze Masafumi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Inzucchi Silvio E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kosiborod Mikhail N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Martinez Felipe A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tereshchenko Sergey </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ponikowski Piotr </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bengtsson Olof </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lindholm Daniel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Langkilde Anna Maria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schou Morten </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sjostrand Mikaela </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Solomon Scott D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sabatine Marc S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chiang Chern-En </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Docherty Kieran F. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jhund Pardeep S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kober Lars </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >McMurray John J. V. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32857208" target="_blank">Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction A Post Hoc Analysis of the DAPA-HF Trial</a></div> <div> <span class="journal-title">ANNALS OF INTERNAL MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0003-4819">0003-4819</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1539-3704">1539-3704</a>)</span>: <span class="journal-volume">175</span> <span class="journal-issue">6</span> <span class="page"> pp 820-830 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.7326/M21-4776" target="_blank" href="https://doi.org/10.7326/M21-4776"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000795125100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000795125100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85132453939" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132453939"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35467935" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35467935&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Internal Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 150</span> | Independent citation: 131 | Self citation: 19 | Unknown citation: 0 | Number of citations in WoS: 142 | Number of citations in Scopus:&nbsp;148 | WoS/Scopus assigned:&nbsp;150 | Number of citations with DOI:&nbsp;148 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32857208&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32857208</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Last Modified: 2023.02.28. 09:07 György Wolf (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: AstraZeneca; British Heart Foundation Centre of Research Excellence [RE/18/6/34217] Funding text: Grant Support: The DAPA-HF trial was funded by AstraZeneca. Dr. McMurray was supported by British Heart Foundation Centre of Research Excellence Grant RE/18/6/34217.</pre> </div></div>