https://m2.mtmt.hu/ hun 2026-09-20 16:05 JournalArticle 32841063 VALIDATED true * Megosztott szerzőség 0 false 2026-09-13T21:45:06.793+0000 2026-03-18T10:49:44.906+0000 2022-05-24T18:31:39.574+0000 true 10013024 Molnár Gergő Attila /api/author/10013024 Author true 10013024 2026-04-24T05:29:49.277+0000 2026-04-24T05:29:49.277+0000 2023-09-02T13:57:31.332+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:21:58.800+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kiss, Zoltán Nationwide Effectiveness of First and Second SARS-CoV2 Booster Vaccines during the Delta and Omicron Pandemic Waves in Hungary (HUN-VE 2 Study) true true /api/journal/10023324 REVIEWED true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 13 905585 905585 9 2022 In Hungary, the pandemic waves in late 2021 and early 2022 were dominated by the Delta and Omicron SARS-CoV-2 variants, respectively. Booster vaccines were offered with one or two doses for the vulnerable population during these periods.The nationwide HUN-VE 2 study examined the effectiveness of primary immunization, single booster, and double booster vaccination in the prevention of Covid-19 related mortality during the Delta and Omicron waves, compared to an unvaccinated control population without prior SARS-CoV-2 infection during the same study periods. The risk of Covid-19 related death was 55% lower during the Omicron vs. Delta wave in the whole study population (n=9,569,648 and n=9,581,927, respectively; rate ratio [RR]: 0.45, 95% confidence interval [CI]: 0.44-0.48). During the Delta wave, the risk of Covid-19 related death was 74% lower in the primary immunized population (RR: 0.26; 95% CI: 0.25-0.28) and 96% lower in the booster immunized population (RR: 0.04; 95% CI: 0.04-0.05), vs. the unvaccinated control group. During the Omicron wave, the risk of Covid-19 related death was 40% lower in the primary immunized population (RR: 0.60; 95% CI: 0.55-0.65) and 82% lower in the booster immunized population (RR: 0.18; 95% CI: 0.16-0.2) vs. the unvaccinated control group. The double booster immunized population had a 93% lower risk of Covid-19 related death compared to those with only one booster dose (RR: 0.07; 95% CI. 0.01-0.46). The benefit of the second booster was slightly more pronounced in older age groups.The HUN-VE 2 study demonstrated the significantly lower risk of Covid-19 related mortality associated with the Omicron vs. Delta variant and confirmed the benefit of single and double booster vaccination against Covid-19 related death. Furthermore, the results showed the additional benefit of a second booster dose in terms of SARS-CoV-2 infection and Covid-19 related mortality. true true 2022 true true true false true false GOLD 2026-09-13 true https://doi.org/10.3389/fimmu.2022.905585 47 0 40 31 16 38 43 35 37 38 38 29 29 37 10 0 47 37 40 31 0 2 2 Folyóiratcikk Journal Article 24 38 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 2 Egyéb Miscellaneous 29 5 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 8 6 8 6 2023 0 17 14 17 14 2024 0 15 13 15 13 2025 0 6 3 6 3 2026 0 1 1 1 1 Q1 false 10013024 false false false 2022-07-27T10:22:47.974+0000 Akadémikus bibliográfia; Belgyógyászati Intézet (DE / ÁOK); Digitális Egészségtudományi Intézet (SE / EKK); Egészségügyi Technológiaértékelő és Elemzési Kö... 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/api/classification/12146 true true SjrRating 11304089 /api/sjrrating/11304089 39 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2403 /api/classificationexternal/2403 true 2403 true Q1 DIRECT true true /api/publication/32841063 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077079"><a href="/gui2/?type=authors&mode=browse&sel=10077079" target="_blank">Kiss Zoltán (<span class="authorship-author-name">Kiss Zoltán</span> <span class="authorAux-mtmt"> A főbb mortalitásért felelős betegségek epidemi...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016656"><a href="/gui2/?type=authors&mode=browse&sel=10016656" target="_blank">Wittmann István<sup>*</sup> (<span class="authorship-author-name">Wittmann István</span> <span class="authorAux-mtmt"> Klinikai orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084707"><a href="/gui2/?type=authors&mode=browse&sel=10084707" target="_blank">Polivka Lőrinc (<span class="authorship-author-name">Polivka Lőrinc</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028053"><a href="/gui2/?type=authors&mode=browse&sel=10028053" target="_blank">Surján György (<span class="authorship-author-name">Surján György</span> <span class="authorAux-mtmt"> Orvosi informatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségügyi Közszolgálati Kar">EKK</span>/Digitális Egészségtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Surján Orsolya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Barcza Zsófia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013024"><a href="/gui2/?type=authors&mode=browse&sel=10013024" target="_blank">Molnár Gergő A. (<span class="authorship-author-name">Molnár Gergő Attila</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10100298"><a href="/gui2/?type=authors&mode=browse&sel=10100298" target="_blank">Nagy Dávid (<span class="authorship-author-name">Nagy Dávid</span> <span class="authorAux-mtmt"> survey statisztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Egészségügyi Technológiaértékelő és Elemzési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012282"><a href="/gui2/?type=authors&mode=browse&sel=10012282" target="_blank">Müller Veronika (<span class="authorship-author-name">Müller Veronika</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003497"><a href="/gui2/?type=authors&mode=browse&sel=10003497" target="_blank">Bogos Krisztina (<span class="authorship-author-name">Bogos Krisztina</span> <span class="authorAux-mtmt"> Tüdőgyógyászat, Klinikai Onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021022"><a href="/gui2/?type=authors&mode=browse&sel=10021022" target="_blank">Nagy Péter (<span class="authorship-author-name">Nagy Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Debreceni Egyetem">DE</span>/Kémia Koordinációs Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017547"><a href="/gui2/?type=authors&mode=browse&sel=10017547" target="_blank">Kenessey István (<span class="authorship-author-name">Kenessey István</span> <span class="authorAux-mtmt"> Patológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064611"><a href="/gui2/?type=authors&mode=browse&sel=10064611" target="_blank">Wéber András (<span class="authorship-author-name">Wéber András</span> <span class="authorAux-mtmt"> Demográfia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pálosi Mihály </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szlávik János </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1323309"><a href="/gui2/?type=authors&mode=browse&sel=1323309" target="_blank">Schaff Zsuzsa (<span class="authorship-author-name">Schaff Zsuzsa</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003464"><a href="/gui2/?type=authors&mode=browse&sel=10003464" target="_blank">Szekanecz Zoltán (<span class="authorship-author-name">Szekanecz Zoltán</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Reumatológiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Belgyógyászati Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Müller Cecília </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024576"><a href="/gui2/?type=authors&mode=browse&sel=10024576" target="_blank">Kásler Miklós<sup>**</sup> (<span class="authorship-author-name">Kásler Miklós</span> <span class="authorAux-mtmt"> Klinikai onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000181"><a href="/gui2/?type=authors&mode=browse&sel=10000181" target="_blank">Vokó Zoltán ✉ (<span class="authorship-author-name">Vokó Zoltán</span> <span class="authorAux-mtmt"> A nem-fertőző betegségek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Egészségügyi Technológiaértékelő és Elemzési Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32841063" target="_blank">Nationwide Effectiveness of First and Second SARS-CoV2 Booster Vaccines during the Delta and Omicron Pandemic Waves in Hungary (HUN-VE 2 Study)</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">13</span> <span class="page"> Paper 905585. 9 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fimmu.2022.905585" target="_blank" href="https://doi.org/10.3389/fimmu.2022.905585"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1101/2022.03.27.22273000v1" target="_blank" href="https://doi.org/10.1101/2022.03.27.22273000v1"> Preprint DOI </a> </span> <span class="id identifier oa_none" title="none"> <a 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Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 47</span> | Független: 37 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 35 | Scopus jelölt:&nbsp;37 | WoS/Scopus jelölt:&nbsp;38 | DOI jelölt:&nbsp;43 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32841063&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32841063</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="special-affiliations"> Speciális affiliáció: Akadémikus bibliográfia </div> <div class="notDuplums"><a target="_blank" href="/api/publication/32841063/notduplums">1 Nem duplumnak jelölés</a> </div> <div class="lastModified">Utolsó módosítás: 2026.03.18. 11:49 Czintula Dóra (SE_KSzE_EgészségTech_Admin5_CD, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:21 Ladányi Gusztáv (MTMT API user, admin) Orbán Zsófia (MTMT ellenőrzés, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>