https://m2.mtmt.hu/ eng 2026-10-24 04:19 JournalArticle 32827542 VALIDATED true 0 false 2026-10-22T11:07:44.701+0000 2023-11-20T11:58:32.660+0000 2022-05-17T14:05:58.609+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-04-28T12:30:56.629+0000 2022-06-29T07:26:54.650+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Zádori, Noémi Prevalence of Autoimmune-phenomena behind Chronic Gastritis of Unknown Origin, and its Role in Poor Histological Outcome of the Stomach : A Single-centre, Retrospective Cross-sectional Study. true true /api/journal/10008069 REVIEWED true false 10008069 false 10008069 true 1841-8724 1842-1121 Journal FOREIGN 31 2 168 175 168 8 2022 The underlying aetiology of chronic gastritis (CG) often remains unknown due to its underrated significance in clinical practice. However, the role of chronic inflammation of the stomach in the development of atrophy, intestinal metaplasia (IM) and eventually of gastric cancer is well documented. We aimed to explore the possible aetiological factors of CG, determine the prevalence of systemic autoimmune disorders in patients with CG of unknown aetiology, and clarify the role of autoantibodies in the development of precancerous lesions in the stomach.This is a retrospective, cross-sectional study, conducted from January 2016 to January 2020, including data from 175 patients with CG. Exclusion criteria were: (1) acute gastritis; (2) reactive gastropathy; (3) gastric cancer; (4) subjects without any serology testing results; and (5) Helicobacter pylori positivity. The primary endpoint was a composite endpoint involving gastric atrophy and IM.Fifty-five per cent of patients with CG had autoantibodies. Systemic lupus erythematosus (SLE)-related antibodies were positive in most of the cases, including antinuclear antibody (ANA) positivity, which was found in 19.13% of the patients. Autoimmune positivity was shown to be associated with precancerous lesions in the stomach (p<0.001): IM, atrophy and IM with atrophy. Anti-parietal cell antibody positivity seems to be a significant risk factor for IM and IM with atrophy. Autoimmune thyroiditis-related antibodies and ANA positivity by itself were only associated with atrophy; SLE-related antibodies and inflammatory bowel diseases related antibodies (ASCA and ANCA) correlated either with IM or with atrophy. No significant relation was found between any other investigated autoimmune disease-related antibodies and precancerous lesions.Autoimmune positivity often underlies gastritis of unknown aetiology and predisposes to precancerous lesions in the stomach. These antibodies can serve as non-invasive markers for the of optimal timing of an endoscopic follow-up strategy. Furthermore, CG can be an early symptom of a systemic autoimmune disorder. Funding 2015447 /api/funding/2015447 false true Funding 2015448 /api/funding/2015448 false true Funding 2015449 /api/funding/2015449 false true true 2022 true true true false true false NONE 2026-10-22 false 7 0 7 6 1 7 7 5 7 7 7 6 6 6 1 0 7 6 7 6 0 0 0 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 2 1 2 1 2023 0 2 2 2 2 2024 0 0 0 0 0 2025 0 3 3 3 3 Q2 false 10013027 false false false 2022-06-26T08:53:00.221+0000 I. sz. Belgyógyászati Klinika (PTE / ÁOK); Pankreász Betegségek Részlege (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Transzlációs medicina kutatócsoport (PTE / SZKK); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 9 35 6 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 101722066 /api/authorship/101722066 1 0.11111111 true false false Author 10071802 /api/author/10071802 Zádori Noémi true true Zádori Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101722067 /api/authorship/101722067 2 0.11111111 false false false Author 10071583 /api/author/10071583 Németh Dávid true true Németh Dávid true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101722068 /api/authorship/101722068 3 0.11111111 false false false Author 10070994 /api/author/10070994 Szakó Lajos true true Szakó Lajos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101722069 /api/authorship/101722069 4 0.11111111 false false false Author 10071961 /api/author/10071961 Váncsa Szilárd true true Váncsa Szilárd true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101722070 /api/authorship/101722070 5 0.11111111 false false false Author 10073124 /api/author/10073124 Vörhendi Nóra true true Vörhendi Nóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101722071 /api/authorship/101722071 6 0.11111111 false false false Author 10062396 /api/author/10062396 Szakács Zsolt true 10062396 true Szakács Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101722072 /api/authorship/101722072 7 0.11111111 false false false Author 10090580 /api/author/10090580 Frim Levente true true Frim Levente true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101722073 /api/authorship/101722073 8 0.11111111 false false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101722074 /api/authorship/101722074 9 0.111 false true true Author 10013027 /api/author/10013027 Czimmer József true 10013027 true Czimmer Jozsef true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20993417 /api/publicationidentifier/20993417 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.15403/jgld-4218 https://doi.org/10.15403/jgld-4218 false true PublicationIdentifier 21182193 /api/publicationidentifier/21182193 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35574624&dopt=Abstract false true PublicationIdentifier 31917877 /api/publicationidentifier/31917877 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://jgld.ro/jgld/index.php/jgld/article/view/4218 https://jgld.ro/jgld/index.php/jgld/article/view/4218 false true Classification 12215 /api/classification/12215 true true SjrRating 11310059 /api/sjrrating/11310059 1071 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q2 DIRECT true true /api/publication/32827542 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071802"><a href="/gui2/?type=authors&mode=browse&sel=10071802" target="_blank">Zádori Noémi (<span class="authorship-author-name">Zádori Noémi</span> <span class="authorAux-mtmt"> Klinikai orvostudományok</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071583"><a href="/gui2/?type=authors&mode=browse&sel=10071583" target="_blank">Németh Dávid (<span class="authorship-author-name">Németh Dávid</span> <span class="authorAux-mtmt"> Biostatisztikus</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070994"><a href="/gui2/?type=authors&mode=browse&sel=10070994" target="_blank">Szakó Lajos (<span class="authorship-author-name">Szakó Lajos</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071961"><a href="/gui2/?type=authors&mode=browse&sel=10071961" target="_blank">Váncsa Szilárd (<span class="authorship-author-name">Váncsa Szilárd</span> <span class="authorAux-mtmt"> Orvostudomány, egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073124"><a href="/gui2/?type=authors&mode=browse&sel=10073124" target="_blank">Vörhendi Nóra (<span class="authorship-author-name">Vörhendi Nóra</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062396"><a href="/gui2/?type=authors&mode=browse&sel=10062396" target="_blank">Szakács Zsolt (<span class="authorship-author-name">Szakács Zsolt</span> <span class="authorAux-mtmt"> Transzlációs Medicina</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/1st Department of Internal Medicine; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090580"><a href="/gui2/?type=authors&mode=browse&sel=10090580" target="_blank">Frim Levente (<span class="authorship-author-name">Frim Levente</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Translational Medicine Research Group; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Pancreatic Diseases</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013027"><a href="/gui2/?type=authors&mode=browse&sel=10013027" target="_blank">Czimmer Jozsef ✉ (<span class="authorship-author-name">Czimmer József</span> <span class="authorAux-mtmt"> Belgyógyászat, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/1st Department of Internal Medicine; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32827542" target="_blank">Prevalence of Autoimmune-phenomena behind Chronic Gastritis of Unknown Origin, and its Role in Poor Histological Outcome of the Stomach : A Single-centre, Retrospective Cross-sectional Study.</a></div> <div> <span class="journal-title">JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1841-8724">1841-8724</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1842-1121">1842-1121</a>)</span>: <span class="journal-volume">31</span> <span class="journal-issue">2</span> <span class="page"> pp 168-175 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.15403/jgld-4218" target="_blank" href="https://doi.org/10.15403/jgld-4218"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000805990400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000805990400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85131903905" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85131903905"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35574624" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35574624&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://jgld.ro/jgld/index.php/jgld/article/view/4218" target="_blank" href="https://jgld.ro/jgld/index.php/jgld/article/view/4218"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Gastroenterology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 6 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;7 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32827542</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> GINOP 2.3.2-15- 2016-00048, EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Funder: NRDIO, (Széchenyi 2020 Programme) </div> <div class="lastModified">Last Modified: 2023.11.20. 12:58 Róbert Milánkovics (PTE ÁOK admin 4) </div> </div></div>