https://m2.mtmt.hu/ eng 2026-09-20 19:46 JournalArticle 32816292 ADMIN_APPROVED true 0 false 2026-08-27T13:31:57.278+0000 2026-02-06T20:44:40.126+0000 2022-05-10T19:47:08.527+0000 true 10039656 Kmety Andrea /api/admin/10039656 Admin true 10039656 2026-02-06T20:44:40.561+0000 2026-02-06T20:44:40.561+0000 2023-01-10T11:08:59.659+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10096252 /api/admin/10096252 Kósa Ilona true true 2026-01-27T08:00:10.801+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Veres, T. An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment true true /api/journal/10038453 REVIEWED true false 10038453 false 10038453 true 2079-4991 Journal FOREIGN 12 9 1476 1476 15 2022 When exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preventing a continuous application during the typical several-cycle multi-week treatment. To solve this issue, our aim was to synthesise an implantable, biodegradable membrane infused with magnetite that enabled long-term treatment while having adequate MRI contrast and hyperthermic capabilities. To immobilise the nanoparticles inside the scaffold, they were synthesised inside hydrogel fibres. First, polysuccinimide (PSI) fibres were produced by electrospinning and crosslinked, and then, magnetitc iron oxide nanoparticles (MIONs) were synthesised inside and in-between the fibres of the hydrogel membranes with the well-known co-precipitation method. The attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) investigation proved the success of the chemical synthesis and the presence of iron oxide, and the superconducting quantum interference device (SQUID) study revealed their superparamagnetic property. The magnetic hyperthermia efficiency of the samples was significant. The given alternating current (AC) magnetic field could induce a temperature rise of 5 degrees C (from 37 degrees C to 42 degrees C) in less than 2 min even for five quick heat-cool cycles or for five consecutive days without considerable heat generation loss in the samples. Short-term (1 day and 7 day) biocompatibility, biodegradability and MRI contrast capability were investigated in vivo on Wistar rats. The results showed excellent MRI contrast and minimal acute inflammation. Funding 2013301 /api/funding/2013301 false true Funding 2013302 /api/funding/2013302 false true Funding 2013303 /api/funding/2013303 false true Funding 2013304 /api/funding/2013304 false true Funding 2013305 /api/funding/2013305 false true Funding 2013306 /api/funding/2013306 false true Funding 2013307 /api/funding/2013307 false true Funding 2013308 /api/funding/2013308 false true Funding 2013309 /api/funding/2013309 false true Funding 2013310 /api/funding/2013310 false true true true 2022 true true true false true false GOLD 2026-08-27 true https://doi.org/10.3390/nano12091476 18 0 18 17 1 18 18 18 18 18 18 17 17 17 1 0 18 17 18 17 0 12 12 Folyóiratcikk Journal Article 24 18 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 6 5 6 5 2024 0 1 1 1 1 2025 0 6 6 6 6 2026 0 3 3 3 3 Q1 false 10056644,10070171,10018916,10053914 false false false 2022-05-09T20:24:27.748+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Fizika Tanszék (BME / TTK / FI); Félvezető nanoszerkezetek csoport (SZFI / ESZO); HCEMM-SE In Vivo Képalkotó Műszerközpont (SE / AOK / I / BSI); Kísérletes és Sebészeti Műtéttani Tanszék (SE / AOK / K); Nem-egyensúlyi ötvözetek csoport (SZFI / KSZO); Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Sebészeti, Transzplantációs és Gasztroenterológ... (SE / AOK / K); Soós Ernő Víztechnológiai Kutatóközpont Nagykan... 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/api/keyword/1187509 true 1187509 true Keyword 1431832 /api/keyword/1431832 true 1431832 true Keyword 1540810 /api/keyword/1540810 true true SjrRating 11288277 /api/sjrrating/11288277 61 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1501 /api/classificationexternal/1501 true 1501 true Q1 DIRECT true true /api/publication/32816292 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Veres T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070171"><a href="/gui2/?type=authors&mode=browse&sel=10070171" target="_blank">Voniatis C.<sup>*</sup> (<span class="authorship-author-name">Voniatis Constantinos</span> <span class="authorAux-mtmt"> Sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040724"><a href="/gui2/?type=authors&mode=browse&sel=10040724" target="_blank">Molnár K. (<span class="authorship-author-name">Molnár Kristóf</span> <span class="authorAux-mtmt"> Gyógyszervegyészmérnök</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032153"><a href="/gui2/?type=authors&mode=browse&sel=10032153" target="_blank">Nesztor D. (<span class="authorship-author-name">Nesztor Dániel</span> <span class="authorAux-mtmt"> Kémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053914"><a href="/gui2/?type=authors&mode=browse&sel=10053914" target="_blank">Fehér D (<span class="authorship-author-name">Fehér Daniella</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Experimental and Clinical Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000698"><a href="/gui2/?type=authors&mode=browse&sel=10000698" target="_blank">Ferencz A (<span class="authorship-author-name">Ferencz Andrea</span> <span class="authorAux-mtmt"> Sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Experimental and Clinical Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056644"><a href="/gui2/?type=authors&mode=browse&sel=10056644" target="_blank">Gresits I. (<span class="authorship-author-name">Gresits Iván</span> <span class="authorAux-mtmt"> fizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Thuróczy G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051901"><a href="/gui2/?type=authors&mode=browse&sel=10051901" target="_blank">Márkus B.G. (<span class="authorship-author-name">Márkus Bence Gábor</span> <span class="authorAux-mtmt"> szilárdtestfizika</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Natural Sciences">FNS</span>/<span title="Institute of Physics">IP</span>/Department of Physics; <span title="Wigner Research Centre for Physics">Wigner</span>/<span title="Institute for Solid State Physics and Optics">SZFI</span>/<span title="Kísérleti Szilárdtestfizikai Osztály">KSZO</span>/Nem-egyensúlyi ötvözetek csoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012456"><a href="/gui2/?type=authors&mode=browse&sel=10012456" target="_blank">Simon F. (<span class="authorship-author-name">Simon Ferenc</span> <span class="authorAux-mtmt"> Szilárdtestfizika</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Natural Sciences">FNS</span>/<span title="Institute of Physics">IP</span>/Department of Physics; <span title="Wigner Research Centre for Physics">Wigner</span>/<span title="Institute for Solid State Physics and Optics">SZFI</span>/<span title="Elméleti Szilárdtest-fizikai Osztály">ESZO</span>/Félvezető nanoszerkezetek csoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nemes N.M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >García-Hernández M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025104"><a href="/gui2/?type=authors&mode=browse&sel=10025104" target="_blank">Reiniger L. (<span class="authorship-author-name">Reiniger Lilla</span> <span class="authorAux-mtmt"> Neuropatológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Horváth I. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054788"><a href="/gui2/?type=authors&mode=browse&sel=10054788" target="_blank">Máthé D. (<span class="authorship-author-name">Máthé Domokos</span> <span class="authorAux-mtmt"> Molekuláris képalkotás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/ACF-SU In Vivo Imaging</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013859"><a href="/gui2/?type=authors&mode=browse&sel=10013859" target="_blank">Szigeti K. (<span class="authorship-author-name">Szigeti Krisztián</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008063"><a href="/gui2/?type=authors&mode=browse&sel=10008063" target="_blank">Tombácz E. (<span class="authorship-author-name">Csákiné Tombácz Etelka</span> <span class="authorAux-mtmt"> Kolloidkémia</span>) </a> </span> <span class="author-affil"><span title="University of Pannonia">UP</span>/<span title="Faculty of Engineering">FE</span>/Soós Ernő Water Technology Research Center Nagykanizsa; <span title="University of Szeged">SZTE</span>/<span title="Faculty of Engineering">FE</span>/Food Engineering Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018916"><a href="/gui2/?type=authors&mode=browse&sel=10018916" target="_blank">Jedlovszky-Hajdu A. ✉ (<span class="authorship-author-name">Jedlovszky-Hajdú Angéla</span> <span class="authorAux-mtmt"> Kolloidkémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32816292" target="_blank">An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment</a></div> <div> <span class="journal-title">NANOMATERIALS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2079-4991">2079-4991</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">9</span> <span class="page"> Paper 1476. 15 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/nano12091476" target="_blank" href="https://doi.org/10.3390/nano12091476"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000794671100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000794671100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85128703428" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85128703428"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35564185" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35564185&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Chemical Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Materials Science (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 17 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 18 | Number of citations in Scopus:&nbsp;18 | WoS/Scopus assigned:&nbsp;18 | Number of citations with DOI:&nbsp;18 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32816292&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32816292</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (K137852) Funder: NRDIO, (TKP2021-NVA-02) Funder: NRDIO, (TKP2021-EGA-02) Funder: NRDIO, (NKFIH FK 124147 National Research, Development and Innovation Office (NRDIO) – Hungary), (137749) Funder: NRDIO, (Bolyai János Kutatási Ösztöndíj) Funder: HAS, (UNKP-20-5-SE-9), European network for advancing electro- magnetic hyperthermic medical technologies(COST CA17115), (Higher Education Institutional Excellence Program of the Ministry of Human Resources in Hungary, within the framework of the Therapeutic Development thematic program of Semmelweis University), HCEMM(739593) Funder: Horizon 2020 </div> <div class="lastModified">Last Modified: 2026.02.06. 21:44 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2026.01.27. 09:00 Ilona Kósa (MTMT központi Admin, admin) </div> </div></div>