Huntington disease is an inherited, progressive, incurable neurodegenerative disorder
that primarily affects cells in the brain. Although the genetic basis for this condition
has been known for nearly 30 years, how this causes disease is still unresolved. Of
late there has been increasing evidence suggesting that dysfunction in macroautophagic/autophagic
pathways may contribute to cellular dysfunction and death. In our recent work we highlight
more precisely how and where this problem might arise in this pathway using directly
reprogrammed neurons.
