https://m2.mtmt.hu/ hun 2026-09-22 19:06 JournalArticle 32804552 VALIDATED true MTA Bolyai János Kutatási Ösztöndíj 0 false 2026-09-01T11:47:40.656+0000 2024-05-30T07:31:21.658+0000 2022-05-04T07:03:07.820+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin Pintér Ibolya Katalin (SE_AOK_TranszlációsMedInt_Admin5_PI, admin) true 2023-09-26T07:33:52.084+0000 2023-09-26T07:33:52.084+0000 2024-05-30T07:31:21.952+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Kökény, Gábor true true /api/journal/2990 REVIEWED KIDNEY INTERNATIONAL 0085-2538 1523-1755 true false 2990 false 2990 true 0085-2538 1523-1755 Journal FOREIGN 102 2 337 354 337 18 2022 Patients with chronic kidney disease and experimental animal models of kidney fibrosis manifest diverse progression rates. Genetic susceptibility may contribute to this diversity, but the causes remain largely unknown. We have previously described kidney fibrosis with a mild or severe phenotype in mice expressing transforming growth factor-beta1 (TGF-β1) under the control of a mouse albumin promoter (Alb/TGFβ1), on a mixed genetic background with CBAxC57Bl6 mice. Here, we aimed to examine how genetic background may influence kidney fibrosis in TGF-β1 transgenic mice, and in the unilateral ureteral obstruction (UUO) and subtotal nephrectomy (SNX) mouse models. Congenic C57Bl6(B6)-TGFβ and CBAxB6-TGFβ (F1) transgenic mice were generated and survival, proteinuria, kidney histology, transcriptome and protein expressions were analyzed. We investigated the kidneys of B6 and CBA mice subjected to UUO and SNX, and the effects of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) neutralization on the fibrotic process. CBAxB6-TGFβ mice developed severe kidney fibrosis and premature death, while B6-TGF-β mice had mild fibrosis and prolonged survival. Kidney early growth response factor-2 (EGR2) and TIMP-1 expression were induced only in CBAxB6-TGFβ mice. Similar strain-dependent early changes in EGR2 and TIMP-1 of mice subjected to UUO or SNX were observed. TIMP-1 neutralization in vivo hindered fibrosis both in transgenic mice and the SNX model. EGR2 over-expression in cultured HEK293 cells induced TIMP-1 while EGR2 silencing hindered TGF-β induced TIMP-1 production in HK-2 cells and ureteral obstructed kidneys. Finally, EGR2 and TIMP1 was increased in human kidneys manifesting focal segmental glomerulosclerosis suggesting a correlation between animal studies and patient clinical settings. Thus, our observations demonstrate a strong relationship between genetic background and the progression of kidney fibrosis, which might involve early altered EGR2 and TIMP-1 response, but the relationship to patient genetics remains to be explored. Funding 2014575 /api/funding/2014575 (PD112960) Támogató: OTKA false true Funding 2014576 /api/funding/2014576 (STIA-OTKA 137266/TMI/2020) false true Funding 2014577 /api/funding/2014577 (BO/ 00304/20/5) false true true true 2022 true true true false true false NONE 2026-09-01 false 30 0 30 26 4 30 30 29 25 30 30 26 26 26 4 0 30 26 30 26 0 3 3 Folyóiratcikk Journal Article 24 30 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 8 7 8 7 2024 0 10 8 10 8 2025 0 6 5 6 5 2026 0 6 6 6 6 D1 false 10015693,1152552,10014641 false false false 2022-08-02T07:03:15.529+0000 Transzlációs Medicina Intézet (SE / AOK / I) 5 26 1 8 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 101528427 /api/authorship/101528427 Kökény, Gábor ✉ [Kökény, Gábor (Nefrológia), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 1 0.125 true false true Author 10014641 /api/author/10014641 Kökény Gábor (Nefrológia) Kökény Gábor true 10014641 true Kökény Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101528428 /api/authorship/101528428 Németh, Ágnes [Németh, Ágnes (Nephrológia), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 2 0.125 false false false Author 10051754 /api/author/10051754 Németh Ágnes (Nephrológia) Németh Ágnes true 10051754 true Németh Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101528429 /api/authorship/101528429 Kopp, Jeffrey B. 3 0.125 false false false Kopp Jeffrey B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101528430 /api/authorship/101528430 Chen, Weiping 4 0.125 false false false Chen Weiping true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101528431 /api/authorship/101528431 Oler, Andrew J. 5 0.125 false false false Oler Andrew J. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101528432 /api/authorship/101528432 Manzéger, Anna [Manzéger, Anna (molekuláris genetika), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 6 0.125 false false false Author 10055151 /api/author/10055151 Manzéger Anna (molekuláris genetika) Manzéger Anna true 10055151 true Manzéger Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101528433 /api/authorship/101528433 Rosivall, László [Rosivall, László (Élettan és kóréle...), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 7 0.125 false false false Author 1152552 /api/author/1152552 Rosivall László (Élettan és kórélettan, nefrológia) Rosivall László true 1152552 true Rosivall László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 101528434 /api/authorship/101528434 Mózes, Miklós M. [Mózes, Miklós (Nephrologia), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 8 0.125 false true false Author 10015693 /api/author/10015693 Mózes Miklós (Nephrologia) Mózes Miklós true 10015693 true Mózes Miklós M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 20930702 /api/publicationidentifier/20930702 DOI: 10.1016/j.kint.2022.03.029 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.kint.2022.03.029 https://doi.org/10.1016/j.kint.2022.03.029 false true PublicationIdentifier 21622775 /api/publicationidentifier/21622775 WoS: 000837056600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000837056600001 https://www.webofscience.com/wos/woscc/full-record/000837056600001 true true PublicationIdentifier 21086537 /api/publicationidentifier/21086537 Scopus: 85130405052 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85130405052 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85130405052 true true PublicationIdentifier 20961899 /api/publicationidentifier/20961899 PubMed: 35513123 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35513123 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35513123&dopt=Abstract true true Classification 12215 /api/classification/12215 Klinikai orvostan true true SjrRating 11314624 /api/sjrrating/11314624 sjr:D1 (2022) Scopus - Nephrology KIDNEY INTERNATIONAL 0085-2538 1523-1755 3 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2727 /api/classificationexternal/2727 Scopus - Nephrology true 2727 true D1 DIRECT true true Reference 30276849 /api/reference/30276849 1. 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(2022) KIDNEY INTERNATIONAL 0085-2538 1523-1755 102 2 337-354<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10014641"><a href="/gui2/?type=authors&mode=browse&sel=10014641" target="_blank">Kökény Gábor ✉ (<span class="authorship-author-name">Kökény Gábor</span> <span class="authorAux-mtmt"> Nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051754"><a href="/gui2/?type=authors&mode=browse&sel=10051754" target="_blank">Németh Ágnes (<span class="authorship-author-name">Németh Ágnes</span> <span class="authorAux-mtmt"> Nephrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kopp Jeffrey B. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chen Weiping </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oler Andrew J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055151"><a href="/gui2/?type=authors&mode=browse&sel=10055151" target="_blank">Manzéger Anna (<span class="authorship-author-name">Manzéger Anna</span> <span class="authorAux-mtmt"> molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1152552"><a href="/gui2/?type=authors&mode=browse&sel=1152552" target="_blank">Rosivall László (<span class="authorship-author-name">Rosivall László</span> <span class="authorAux-mtmt"> Élettan és kórélettan, nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015693"><a href="/gui2/?type=authors&mode=browse&sel=10015693" target="_blank">Mózes Miklós M. (<span class="authorship-author-name">Mózes Miklós</span> <span class="authorAux-mtmt"> Nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32804552" target="_blank">Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metaloproteinase-1 expression</a></div> <div> <span class="journal-title">KIDNEY INTERNATIONAL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0085-2538">0085-2538</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1523-1755">1523-1755</a>)</span>: <span class="journal-volume">102</span> <span class="journal-issue">2</span> <span class="page"> pp 337-354 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.kint.2022.03.029" target="_blank" href="https://doi.org/10.1016/j.kint.2022.03.029"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000837056600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000837056600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85130405052" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85130405052"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35513123" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35513123&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nephrology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 30</span> | Független: 26 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 29 | Scopus jelölt:&nbsp;25 | WoS/Scopus jelölt:&nbsp;30 | DOI jelölt:&nbsp;30 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32804552&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32804552</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (PD112960) Támogató: OTKA, (STIA-OTKA 137266/TMI/2020), (BO/ 00304/20/5) </div> <div class="lastModified">Utolsó módosítás: 2024.05.30. 09:31 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: MTA Bolyai János Kutatási Ösztöndíj</pre> </div></div>