https://m2.mtmt.hu/ hun 2026-09-21 02:42 JournalArticle 32801152 VALIDATED true Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, H-7624, Rókus u. 2, Pécs, Hungary Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Pécs, H-7624, Rókus u. 2, Pécs, Hungary Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 98168, Italy Chromaleont s.r.l., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 98168, Italy Unit of Food Science and Nutrition, Department of Medicine, University Campus Bio-Medico of Rome, Rome, 00128, Italy Institute of Pharmacognosy, Faculty of Pharmacy, Semmelweis University, H-1085 Üllői út 26, Budapest, Hungary Mikszáth Pharmacy, H-1088, Mikszát Kálmán tér 4, Budapest, Hungary Export Date: 14 August 2026; Cited By: 24; Correspondence Address: G. Horváth; Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, Pécs, H-7624, Rókus u. 2, Hungary; email: horvath.gyorgyi@gytk.pte.hu 0 false 2026-08-25T09:54:09.599+0000 2026-08-14T10:08:39.425+0000 2022-05-02T05:46:44.930+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-08-14T12:04:19.741+0000 2024-12-06T18:01:09.889+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Horváth, Adrienn Anti-inflammatory effects of lavender and eucalyptus essential oils on the in vitro cell culture model of bladder pain syndrome using T24 cells. true true /api/journal/20075960 REVIEWED true false false 20075960 true 2662-7671 Journal FOREIGN 22 1 119 119 14 2022 Interstitial cystitis (IC) has a chronic chemical irritation and inflammation of non-bacterial origin in the bladder wall leading to various severe symptoms. There is evidence that chronic inflammation is significantly associated with abnormal urothelial barrier function, epithelial dysfunction. This is the underlying cause of urothelial apoptosis and sterile inflammation.The anti-inflammatory effects of lavender and eucalyptus essential oils (EOs) and their main components (linalool and eucalyptol) were investigated in the T24 human bladder epithelial cell line on TNFα stimulated inflammation, at 3 types of treatment schedule. The mRNA of pro-inflammatory cytokines (IL-1β, IL-6, IL-8) were measured by Real Time PCR. Human IL-8 ELISA measurement was performed as well at 3 types of treatment schedule. The effects of lavender and eucalyptus EOs and their main components were compared to the response to NFκB inhibitor ACHP (2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile).There is no significant difference statistically, but measurements show that lavender EOs are more effective than eucalyptus EO. Long time treatment (24 h) of both lavender EO and linalool showed higher effect in decreasing pro-inflammatory cytokine mRNA expression than ACHP inhibitor following TNFα pre-treatment. Moreover, both lavender EOs were found to be significantly more effective in decreasing IL-8 secretion of T24 cells after TNFα pre-treatment compared to the ACHP NFκB-inhibitor.The lavender EOs may be suitable for use as an adjunct to intravesical therapy of IC. Their anti-inflammatory effect could well complement glycosaminoglycan-regenerative therapy in the urinary bladder after appropriate pharmaceutical formulation. 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Farmakognóziai Intézet (SE / GYTK); Gyógyszerészi Biológia Tanszék (PTE / GYTK) 6 31 3 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 101501988 /api/authorship/101501988 1 0.125 true false false Author 10064729 /api/author/10064729 Horváth Adrienn true 10064729 true Horváth Adrienn true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101501989 /api/authorship/101501989 2 0.125 false false false Author 10019183 /api/author/10019183 Pandur Edina true 10019183 true Pandur Edina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101501990 /api/authorship/101501990 3 0.125 false false false Author 10016606 /api/author/10016606 Sipos Katalin true 10016606 true Sipos Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101501991 /api/authorship/101501991 4 0.125 false false false Micalizzi Giuseppe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101501992 /api/authorship/101501992 5 0.125 false false false Mondello Luigi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101501993 /api/authorship/101501993 6 0.125 false false false Author 10032429 /api/author/10032429 Böszörményi Andrea true 10032429 true Böszörményi Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101501994 /api/authorship/101501994 7 0.125 false false false Author 10040433 /api/author/10040433 Birinyi Péter true 10040433 true Birinyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101501995 /api/authorship/101501995 8 0.125 false true true Author 10016483 /api/author/10016483 Horváth Györgyi true 10016483 true Horváth Györgyi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20921994 /api/publicationidentifier/20921994 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s12906-022-03604-2 https://doi.org/10.1186/s12906-022-03604-2 false true PublicationIdentifier 20968980 /api/publicationidentifier/20968980 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000789058900001 https://www.webofscience.com/wos/woscc/full-record/000789058900001 false true PublicationIdentifier 20986105 /api/publicationidentifier/20986105 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85129140093 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85129140093 false true PublicationIdentifier 20921993 /api/publicationidentifier/20921993 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35490236 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35490236&dopt=Abstract false true Keyword 1044237 /api/keyword/1044237 true 1044237 true Keyword 1572010 /api/keyword/1572010 true true Keyword 1670405 /api/keyword/1670405 true true Keyword 1674214 /api/keyword/1674214 true true Keyword 1901649 /api/keyword/1901649 true true Keyword 2216935 /api/keyword/2216935 true true Keyword 2270430 /api/keyword/2270430 true true SjrRating 11312172 /api/sjrrating/11312172 12 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2707 /api/classificationexternal/2707 true 2707 true Q1 DIRECT true true /api/publication/32801152 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10064729"><a href="/gui2/?type=authors&mode=browse&sel=10064729" target="_blank">Horváth Adrienn (<span class="authorship-author-name">Horváth Adrienn</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Biológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019183"><a href="/gui2/?type=authors&mode=browse&sel=10019183" target="_blank">Pandur Edina (<span class="authorship-author-name">Pandur Edina</span> <span class="authorAux-mtmt"> Gyógyszerészi biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Biológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016606"><a href="/gui2/?type=authors&mode=browse&sel=10016606" target="_blank">Sipos Katalin (<span class="authorship-author-name">Sipos Katalin</span> <span class="authorAux-mtmt"> Expressziós analízis, fehérje interakciók, RNS ...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Biológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Micalizzi Giuseppe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mondello Luigi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032429"><a href="/gui2/?type=authors&mode=browse&sel=10032429" target="_blank">Böszörményi Andrea (<span class="authorship-author-name">Böszörményi Andrea</span> <span class="authorAux-mtmt"> gázkromatográfia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040433"><a href="/gui2/?type=authors&mode=browse&sel=10040433" target="_blank">Birinyi Péter (<span class="authorship-author-name">Birinyi Péter</span> <span class="authorAux-mtmt"> gyógyszerészet</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016483"><a href="/gui2/?type=authors&mode=browse&sel=10016483" target="_blank">Horváth Györgyi ✉ (<span class="authorship-author-name">Horváth Györgyi</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32801152" target="_blank">Anti-inflammatory effects of lavender and eucalyptus essential oils on the in vitro cell culture model of bladder pain syndrome using T24 cells.</a></div> <div> <span class="journal-title">BMC COMPLEMENTARY MEDICINE AND THERAPIES</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2662-7671">2662-7671</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">1</span> <span class="page"> Paper 119. 14 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12906-022-03604-2" target="_blank" href="https://doi.org/10.1186/s12906-022-03604-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000789058900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000789058900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85129140093" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85129140093"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35490236" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35490236&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 28</span> | Független: 28 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 22 | Scopus jelölt:&nbsp;24 | WoS/Scopus jelölt:&nbsp;24 | DOI jelölt:&nbsp;27 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32801152&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32801152</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (EFOP-3.6.1.-16-2016-00004) Támogató: EFOP, (K 128217) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2026.08.14. 12:08 Nagy Liliána (PTE ÁOK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, H-7624, Rókus u. 2, Pécs, Hungary Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Pécs, H-7624, Rókus u. 2, Pécs, Hungary Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 98168, Italy ...</pre> </div></div>