https://m2.mtmt.hu/ eng 2026-10-24 10:53 JournalArticle 32793577 VALIDATED true Human Brain Research Laboratory, Institute of Experimental Medicine, ELKH, Budapest, 1083, Hungary Szentágothai János Doctoral School of Neuroscience, Semmelweis University, Budapest, 1085, Hungary Department of Functional Neurosurgery and Center of Neuromodulation, National Institute of Mental Health Neurology and Neurosurgery, Budapest, 1145, Hungary Department of Pathology, St. Borbála Hospital, Tatabánya, 2800, Hungary Cited By :1 Export Date: 4 May 2023 Correspondence Address: Maglóczky, Z.; Human Brain Research Laboratory, Hungary; email: magloczky.zsofia@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K 125436 Funding details: National Research, Development and Innovation Office Funding text 1: Funding: National Research, Development, and Innovation Office (NKFI, Hungary, grant number K 125436, Z. Maglóczky) and the National Brain Research Program (2017-1.2.1-NKP-2017-00002). 0 false 2026-10-22T09:52:25.656+0000 2024-08-22T08:34:31.793+0000 2022-04-26T06:44:31.255+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-09-03T08:58:28.526+0000 2026-09-03T08:58:28.526+0000 2024-08-22T08:34:32.169+0000 true 10095366 Havas Petra Gabriella /api/admin/10095366 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szekeres-Paraczky, Cecília Reorganization of Parvalbumin Immunopositive Perisomatic Innervation of Principal Cells in Focal Cortical Dysplasia Type IIB in Human Epileptic Patients true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 23 9 4746 4746 19 2022 Focal cortical dysplasia (FCD) is one of the most common causes of drug-resistant epilepsy. As several studies have revealed, the abnormal functioning of the perisomatic inhibitory system may play a role in the onset of seizures. Therefore, we wanted to investigate whether changes of perisomatic inhibitory inputs are present in FCD. Thus, the input properties of abnormal giant- and control-like principal cells were examined in FCD type IIB patients. Surgical samples were compared to controls from the same cortical regions with short postmortem intervals. For the study, six subjects were selected/each group. The perisomatic inhibitory terminals were quantified in parvalbumin and neuronal nuclei double immunostained sections using a confocal fluorescent microscope. The perisomatic input of giant neurons was extremely abundant, whereas control-like cells of the same samples had sparse inputs. A comparison of pooled data shows that the number of parvalbumin-immunopositive perisomatic terminals contacting principal cells was significantly larger in epileptic cases. The analysis showed some heterogeneity among epileptic samples. However, five out of six cases had significantly increased perisomatic input. Parameters of the control cells were homogenous. The reorganization of the perisomatic inhibitory system may increase the probability of seizure activity and might be a general mechanism of abnormal network activity. 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Institute of Experimental Medicine; <span title="Institute of Experimental Medicine">IEM</span>/Human Brain Research Laboratory</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064391"><a href="/gui2/?type=authors&mode=browse&sel=10064391" target="_blank">Szocsics Péter (<span class="authorship-author-name">Szocsics Péter</span> <span class="authorAux-mtmt"> idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; Institute of Experimental Medicine; <span title="Institute of Experimental Medicine">IEM</span>/Human Brain Research Laboratory</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026870"><a href="/gui2/?type=authors&mode=browse&sel=10026870" target="_blank">Erőss Loránd (<span class="authorship-author-name">Erőss Loránd</span> <span class="authorAux-mtmt"> Idegsebészet, ideggyógyászat</span>) </a> </span> <span class="author-affil">Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="161"><a href="/gui2/?type=authors&mode=browse&sel=161" target="_blank">Fabó Dániel (<span class="authorship-author-name">Fabó Dániel</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Institute of Neurology and Neurosurgery (Amerikai street)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mód László </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009112"><a href="/gui2/?type=authors&mode=browse&sel=10009112" target="_blank">Maglóczky Zsófia ✉ (<span class="authorship-author-name">Maglóczky Zsófia</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet; <span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Human Brain Research Laboratory</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32793577" target="_blank">Reorganization of Parvalbumin Immunopositive Perisomatic Innervation of Principal Cells in Focal Cortical Dysplasia Type IIB in Human Epileptic Patients</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">9</span> <span class="page"> Paper 4746. 19 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms23094746" target="_blank" href="https://doi.org/10.3390/ijms23094746"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000794543600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000794543600001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="160676" target="_blank" href="https://real.mtak.hu/160676"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85128706760" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85128706760"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35563137" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35563137&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 11</span> | Independent citation: 7 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 11 | Number of citations in Scopus:&nbsp;11 | WoS/Scopus assigned:&nbsp;11 | Number of citations with DOI:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32793577&sort=publishedYear,desc&sort=title"> Number of cited publications: 16 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32793577</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> NKFI(K 125436), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002) </div> <div class="lastModified">Last Modified: 2024.08.22. 10:34 Petra Gabriella Havas (SE_KK_Idegsebeszet_Admin5_HP, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Human Brain Research Laboratory, Institute of Experimental Medicine, ELKH, Budapest, 1083, Hungary Szentágothai János Doctoral School of Neuroscience, Semmelweis University, Budapest, 1085, Hungary Department of Functional Neurosurgery and Center of Neuromodulation, National Institute of Mental Health Neurology and Neurosurgery, Budapest, 1145, Hu...</pre> </div></div>