Elevated serum purine levels in schizophrenia: a reverse translational study to identify novel inflammatory biomarkers

Kristóf, Zsüliet [Kristóf, Zsüliet (pszichológia, psz...), author] School of PhD Studies (SU); Laboratory of Molecular Pharmacology; Baranyi, Mária [Baranyi, Mária (Molekuláris farma...), author] Laboratory of Molecular Pharmacology; Tod, Pál [Tod, Pál (Purinerg jelátvit...), author] Laboratory of Molecular Pharmacology; Mut-Arbona, Paula [Mut-Arbona, Paula (Neuroscience), author] School of PhD Studies (SU); Laboratory of Molecular Pharmacology; Demeter, Kornél [Demeter, Kornél (Idegi őssejt biol...), author] Institute of Experimental Medicine; Behavioral Studies Unit; Bitter, István** [Bitter, István (Elmekórtan), author] Pszichiátriai és Pszichoterápiás Klinika (SU / FM / C); School of PhD Studies (SU); Sperlágh, Beáta ✉ [Sperlágh, Beáta (Neurofarmakológia), author] School of PhD Studies (SU); Laboratory of Molecular Pharmacology; Institute of Experimental Medicine

English Article (Journal Article) Scientific
Published: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 1461-1457 1469-5111 25 (8) pp. 645-659 2022
  • SJR Scopus - Pharmacology (medical): D1
Identifiers
Fundings:
  • Hungarian Research and Development Fund(131629)
  • Hungarian Brain Research Program(2017-1.2.1-NKP-2017-00002)
  • Horizon 2020 Framework Programme(H2020 766124)
Immunological markers and related signaling molecules in the blood are altered in schizophrenia mouse models, in acutely relapsed patients with schizophrenia, and in persons at a clinically high risk for subsequently developing psychosis, highlighting their potential as prognostic and theranostic biomarkers. Therefore, we herein aimed to identify novel potential biomarkers in the serum that are associated with purinergic signaling.
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2025-04-25 20:37