https://m2.mtmt.hu/ eng 2026-10-24 00:05 JournalArticle 32789125 APPROVED true 0 false 2026-10-22T09:39:31.487+0000 2025-02-25T23:17:33.478+0000 2022-04-21T11:48:12.171+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Márta Turek (KOKI admin 4) true 2026-05-20T13:09:21.035+0000 2026-05-20T13:09:21.035+0000 Admin 10003134 /api/admin/10003134 György Wolf (MTMT Központi admin) Wolf György true 10003134 true 2024-01-18T08:31:41.494+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Durst, Máté true true /api/journal/39990 REVIEWED FRONTIERS IN NEUROSCIENCE 1662-4548 1662-453X true false 39990 false 39990 true 1662-4548 1662-453X Journal FOREIGN 16 828571 828571 12 2022 Intrauterine growth retardation (IUGR) poses a high risk for developing late-onset, non-obese type 2 diabetes (T2DM). The exact mechanism underlying this phenomenon is unknown, although the contribution of the central nervous system is recognized. The main hypothalamic nuclei involved in the homeostatic regulation express nesfatin-1, an anorexigenic neuropeptide and identified regulator of blood glucose level. Using intrauterine protein restricted rat model (PR) of IUGR, we investigated, whether IUGR alters the function of nesfatin-1. We show that PR rats develop fat preference and impaired glucose homeostasis by adulthood, while the body composition and caloric intake of normal nourished (NN) and PR rats are similar. Plasma nesfatin-1 levels are unaffected by IUGR in both neonates and adults, but pro-nesfatin-1 mRNA expression is upregulated in the hypothalamus of adult PR animals. We find that centrally injected nesfatin-1 inhibits the fasting induced neuronal activation in the hypothalamic arcuate nucleus in adult NN rats. This effect of nesfatin-1 is not seen in PR rats. The anorexigenic effect of centrally injected nesfatin-1 is also reduced in adult PR rats. Moreover, chronic central nesfatin-1 administration improves the glucose tolerance and insulin sensitivity in NN rats but not in PR animals. Birth dating of nesfatin-1 cells by bromodeoxyuridine (BrDU) reveals that formation of nesfatin-1 cells in the hypothalamus of PR rats is disturbed. Our results suggest that adult PR rats acquire hypothalamic nesfatin-1-resistance, probably due to the altered development of the hypothalamic nesfatin-1 cells. Hypothalamic nesfatin-1-resistance, in turn, may contribute to the development of non-obese type T2DM. Funding 2012712 /api/funding/2012712 Hungarian National Research(Grant Nos. NKFI K115422) false true Funding 2012713 /api/funding/2012713 Hungarian National Research(KP2021-EGA-25) false true Funding 2012714 /api/funding/2012714 Ministry of Innovation and Technology of Hungary from the National Research, Development and Inno...(TKP2021-EGA) false true Funding 2012983 /api/funding/2012983 (K134357) false true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3389/fnins.2022.828571 10 0 10 8 2 10 10 9 7 10 10 8 8 8 2 0 10 8 10 8 0 8 8 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 3 3 3 3 2024 0 1 0 1 0 2025 0 3 2 3 2 2026 0 3 3 3 3 Q2 false 10001325 false false false 2022-04-26T07:00:23.530+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Integratív Neuroendokrinológiai Kutatócsoport (HRN KOKI); Kísérleti Orvostudományi Kutatóintézet; Élettani Intézet (SE / AOK / I) 8 36 4 8 0 true 10003134 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 101393664 /api/authorship/101393664 Durst, Máté [Durst, Máté (idegtudományok), author] Anatómiai, Szövet- és Fejlődéstani Intézet (SU / FM / I) 1 0.125 true false false Author 10051107 /api/author/10051107 Máté Durst (idegtudományok) Durst Máté true 10051107 true Durst Máté true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101393665 /api/authorship/101393665 Könczöl, Katalin* [Könczöl, Katalin (neurobiológia), author] Anatómiai, Szövet- és Fejlődéstani Intézet (SU / FM / I) 2 0.125 true false false Author 10024762 /api/author/10024762 Katalin Könczöl (neurobiológia) Könczöl Katalin true 10024762 true Könczöl Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101393666 /api/authorship/101393666 Ocskay, Klementina [Ocskay, Klementina (Orvostudományok), author] Anatómiai, Szövet- és Fejlődéstani Intézet (SU / FM / I) 3 0.125 false false false Author 10074191 /api/author/10074191 Klementina Ocskay (Orvostudományok) Ocskay Klementina true true Ocskay Klementina true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101393667 /api/authorship/101393667 Sípos, Klaudia [Sípos, Klaudia, author] Anatómiai, Szövet- és Fejlődéstani Intézet (SU / FM / I) 4 0.125 false false false Author 10072403 /api/author/10072403 Klaudia Sípos Sípos Klaudia true true Sípos Klaudia true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101393668 /api/authorship/101393668 Várnai, Péter [Várnai, Péter (Sejtélettan), author] Department of Physiology (SU / FM / I) 5 0.125 false false false Author 10001362 /api/author/10001362 Péter Várnai (Sejtélettan) Várnai Péter true 10001362 true Várnai Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101393669 /api/authorship/101393669 Szilvásy-Szabó, Anett [Stiftné Szilvásy-Szabó, Anett (Neuroendokrinológia), author] Integratív Neuroendokrinológiai Kutatócsoport 6 0.125 false false false Author 10055055 /api/author/10055055 Anett Stiftné Szilvásy-Szabó (Neuroendokrinológia) Stiftné Szilvásy-Szabó Anett true 10055055 true Szilvásy-Szabó Anett true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101393670 /api/authorship/101393670 Fekete, Csaba [Fekete, Csaba (Neuroendokrinológia), author] Integratív Neuroendokrinológiai Kutatócsoport; Institute of Experimental Medicine 7 0.125 false false false Author 10012354 /api/author/10012354 Csaba Fekete (Neuroendokrinológia) Fekete Csaba true 10012354 true Fekete Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101393671 /api/authorship/101393671 Tóth, Zsuzsanna E. ✉ [Tóth, Zsuzsanna (Neuromorfológia, ...), author] Anatómiai, Szövet- és Fejlődéstani Intézet (SU / FM / I) 8 0.125 false true true Author 10001325 /api/author/10001325 Zsuzsanna Tóth (Neuromorfológia, neuroendokrinológia) Tóth Zsuzsanna true 10001325 true Tóth Zsuzsanna E. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 20893854 /api/publicationidentifier/20893854 DOI: 10.3389/fnins.2022.828571 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fnins.2022.828571 https://doi.org/10.3389/fnins.2022.828571 false true PublicationIdentifier 20928295 /api/publicationidentifier/20928295 WoS: 000780297300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000780297300001 https://www.webofscience.com/wos/woscc/full-record/000780297300001 true true PublicationIdentifier 23145933 /api/publicationidentifier/23145933 REAL: 160659 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true 160659 https://real.mtak.hu/160659 false true PublicationIdentifier 20893856 /api/publicationidentifier/20893856 Scopus: 85127989862 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85127989862 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85127989862 false true PublicationIdentifier 20908681 /api/publicationidentifier/20908681 PubMed: 35386592 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35386592 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35386592&dopt=Abstract true true Classification 12291 /api/classification/12291 Diabetology true true Keyword 1522808 /api/keyword/1522808 cFos true true Keyword 2618500 /api/keyword/2618500 nesfatin-1 true true Keyword 2618502 /api/keyword/2618502 IP-GTT true true Keyword 2618507 /api/keyword/2618507 IP-ITT true true Keyword 2618509 /api/keyword/2618509 neuronal birth dating true true SjrRating 11319492 /api/sjrrating/11319492 sjr:Q2 (2022) Scopus - Neuroscience (miscellaneous) FRONTIERS IN NEUROSCIENCE 1662-4548 1662-453X 40 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 Scopus - Neuroscience (miscellaneous) true 2801 true Q2 DIRECT true true Reference 29942155 /api/reference/29942155 1. Al-Goblan 2014: Mechanism linking diabetes mellitus and obesity.., Diabetes Metab. Syndr. Obes., 7, p. 587, DOI: 10.2147/dmso.S67400 1 10.2147/dmso.S67400 false true Reference 29942156 /api/reference/29942156 2. Altman 1986: The development of the rat hypothalamus.., Adv. Anat. Embryol. Cell Biol., 100, p. 1, DOI: 10.1007/978-3-642-71301-9_1 2 10.1007/978-3-642-71301-9_1 false true Reference 29942157 /api/reference/29942157 3. Barker 1993: Fetal nutrition and cardiovascular disease in adult life.., Lancet, 341, p. 938, DOI: 10.1016/0140-6736(93)91224-a 3 10.1016/0140-6736(93)91224-a false true Reference 29942158 /api/reference/29942158 4. Barron 2020: Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study.., Lancet Diabetes Endocrinol., 8, p. 813, DOI: 10.1016/s2213-8587(20)30272-2 4 10.1016/s2213-8587(20)30272-2 false true Reference 29942159 /api/reference/29942159 5. Becskei 2009: Blunted fasting-induced hypothalamic activation and refeeding hyperphagia in late-onset obesity.., Neuroendocrinology, 90, p. 371, DOI: 10.1159/000251723 5 10.1159/000251723 false true Reference 29942160 /api/reference/29942160 6. Betley 2013: Parallel, redundant circuit organization for homeostatic control of feeding behavior.., Cell, 155, p. 1337, DOI: 10.1016/j.cell.2013.11.002 6 10.1016/j.cell.2013.11.002 false true Reference 29942161 /api/reference/29942161 7. Brailoiu 2007: Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain.., Endocrinology, 148, p. 5088, DOI: 10.1210/en.2007-0701 7 10.1210/en.2007-0701 false true Reference 29942162 /api/reference/29942162 8. Carey 2013: Evidence for central regulation of glucose metabolism.., J. Biol. Chem., 288, p. 34981, DOI: 10.1074/jbc.R113.506782 8 10.1074/jbc.R113.506782 false true Reference 29942163 /api/reference/29942163 9. Chen 2012: Radioactive in situ hybridization for detecting diverse gene expression patterns in tissue.., J. Vis. Exp., 62, DOI: 10.3791/3764 9 10.3791/3764 false true Reference 29942164 /api/reference/29942164 10. Chen 2012: Nesfatin-1 influences the excitability of glucosensing neurons in the hypothalamic nuclei and inhibits the food intake.., Regul. Pept., 177, p. 21, DOI: 10.1016/j.regpep.2012.04.003 10 10.1016/j.regpep.2012.04.003 false true Reference 29942165 /api/reference/29942165 11. Desai 2007: The timing of nutrient restriction during rat pregnancy/lactation alters metabolic syndrome phenotype.., Am. J. Obstet. Gynecol., 196, p. 555.e1, DOI: 10.1016/j.ajog.2006.11.036 11 10.1016/j.ajog.2006.11.036 false true Reference 29942166 /api/reference/29942166 12. Dodd 2018: Insulin regulates POMC neuronal plasticity to control glucose metabolism.., eLife, 7, DOI: 10.7554/eLife.38704 12 10.7554/eLife.38704 false true Reference 29942167 /api/reference/29942167 13. Durst 2019: Reward-representing D1-type neurons in the medial shell of the accumbens nucleus regulate palatable food intake.., Int. J. Obes., 43, p. 917, DOI: 10.1038/s41366-018-0133-y 13 10.1038/s41366-018-0133-y false true Reference 29942168 /api/reference/29942168 14. Fekete 2012: Activation of anorexigenic pro-opiomelanocortin neurones during refeeding is independent of vagal and brainstem inputs.., J. Neuroendocrinol., 24, p. 1423, DOI: 10.1111/j.1365-2826.2012.02354.x 14 10.1111/j.1365-2826.2012.02354.x false true Reference 29942169 /api/reference/29942169 15. Foo 2008: Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS.., Neuroscience, 156, p. 563, DOI: 10.1016/j.neuroscience.2008.07.054 15 10.1016/j.neuroscience.2008.07.054 false true Reference 29942170 /api/reference/29942170 16. Gantulga 2012: Glucose and insulin induce Ca2+ signaling in nesfatin-1 neurons in the hypothalamic paraventricular nucleus.., Biochem. Biophys. Res. Commun., 420, p. 811, DOI: 10.1016/j.bbrc.2012.03.079 16 10.1016/j.bbrc.2012.03.079 false true Reference 29942171 /api/reference/29942171 17. Guo 2013: Increased nucleobindin-2 (NUCB2) transcriptional activity links the regulation of insulin sensitivity in Type 2 diabetes mellitus.., J. Endocrinol. Invest., 36, p. 883, DOI: 10.3275/9000 17 10.3275/9000 false true Reference 29942172 /api/reference/29942172 18. Kleinridders 2009: CNS-targets in control of energy and glucose homeostasis.., Curr. Opin. Pharmacol., 9, p. 794, DOI: 10.1016/j.coph.2009.10.006 18 10.1016/j.coph.2009.10.006 false true Reference 29942173 /api/reference/29942173 19. Konczol 2010: Nesfatin-1/NUCB2 may participate in the activation of the hypothalamic-pituitary-adrenal axis in rats.., Neurochem. Int., 57, p. 189, DOI: 10.1016/j.neuint.2010.04.012 19 10.1016/j.neuint.2010.04.012 false true Reference 29942174 /api/reference/29942174 20. Könczöl 2012: Nesfatin-1 exerts long-term effect on food intake and body temperature.., Int. J. Obes., 36, p. 1514, DOI: 10.1038/ijo.2012.2 20 10.1038/ijo.2012.2 false true Reference 29942175 /api/reference/29942175 21. Könner 2007: Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.., Cell Metab., 5, p. 438, DOI: 10.1016/j.cmet.2007.05.004 21 10.1016/j.cmet.2007.05.004 false true Reference 29942176 /api/reference/29942176 22. Langley-Evans 2005: Animal models of programming: early life influences on appetite and feeding behaviour.., Matern Child Nutr., 1, p. 142, DOI: 10.1111/j.1740-8709.2005.00015.x 22 10.1111/j.1740-8709.2005.00015.x false true Reference 29942177 /api/reference/29942177 23. Levin 2006: Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis.., Philos. Trans. R. Soc. Lond. B Biol. Sci., 361, p. 1107, DOI: 10.1098/rstb.2006.1851 23 10.1098/rstb.2006.1851 false true Reference 29942178 /api/reference/29942178 24. Maejima 2009: Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway.., Cell Metab., 10, p. 355, DOI: 10.1016/j.cmet.2009.09.002 24 10.1016/j.cmet.2009.09.002 false true Reference 29942179 /api/reference/29942179 25. Maejima 2018: The anorexigenic neural pathways of oxytocin and their clinical implication.., Neuroendocrinology, 107, p. 91, DOI: 10.1159/000489263 25 10.1159/000489263 false true Reference 29942180 /api/reference/29942180 26. Markakis 2002: Development of the neuroendocrine hypothalamus.., Front. Neuroendocrinol., 23, p. 257, DOI: 10.1016/s0091-3022(02)00003-1 26 10.1016/s0091-3022(02)00003-1 false true Reference 29942181 /api/reference/29942181 27. Martin-Gronert 2007: Experimental IUGR and later diabetes.., J. Intern. Med., 261, p. 437, DOI: 10.1111/j.1365-2796.2007.01800.x 27 10.1111/j.1365-2796.2007.01800.x false true Reference 29942182 /api/reference/29942182 28. Nakata 2013: Role of NUCB2/nesfatin-1 in glucose control: diverse functions in islets, adipocytes and brain.., Curr. Pharm. Des., 19, p. 6960, DOI: 10.2174/138161281939131127130112 28 10.2174/138161281939131127130112 false true Reference 29942183 /api/reference/29942183 29. Oh-I 2006: Identification of nesfatin-1 as a satiety molecule in the hypothalamus.., Nature, 443, p. 709, DOI: 10.1038/nature05162 29 10.1038/nature05162 false true Reference 29942184 /api/reference/29942184 30. Paxinos 2007: The Rat Brain in Stereotaxic Coordinates 30 false true Reference 29942185 /api/reference/29942185 31. Pedroso 2017: Intrauterine growth restriction programs the hypothalamus of adult male rats: integrated analysis of proteomic and metabolomic data.., J. Proteome Res., 16, p. 1515, DOI: 10.1021/acs.jproteome.6b00923 31 10.1021/acs.jproteome.6b00923 false true Reference 29942186 /api/reference/29942186 32. Pinney 2013: Intrauterine growth retardation - A developmental model of type 2 diabetes.., Drug Discov. Today Dis. Models, 10, p. e71, DOI: 10.1016/j.ddmod.2013.01.003 32 10.1016/j.ddmod.2013.01.003 false true Reference 29942187 /api/reference/29942187 33. Polyak 2016: Brown adipose tissue in obesity: Fractalkine-receptor dependent immune cell recruitment affects metabolic-related gene expression.., Biochim. Biophys. Acta, 1861, p. 1614, DOI: 10.1016/j.bbalip.2016.07.002 33 10.1016/j.bbalip.2016.07.002 false true Reference 29942188 /api/reference/29942188 34. Pozo 2018: Hypothalamic control of systemic glucose homeostasis: the pancreas connection.., Trends Endocrinol. Metab., 29, p. 581, DOI: 10.1016/j.tem.2018.05.001 34 10.1016/j.tem.2018.05.001 false true Reference 29942189 /api/reference/29942189 35. Price 2008: Nesfatin-1 inhibits NPY neurons in the arcuate nucleus.., Brain Res., 1230, p. 99, DOI: 10.1016/j.brainres.2008.06.084 35 10.1016/j.brainres.2008.06.084 false true Reference 29942190 /api/reference/29942190 36. Saleem 2011: Intrauterine growth retardation–small events, big consequences.., Ital. J. Pediatr., 37, DOI: 10.1186/1824-7288-37-41 36 10.1186/1824-7288-37-41 false true Reference 29942191 /api/reference/29942191 37. Sandoval 2009: Targeting the CNS to treat type 2 diabetes.., Nat. Rev. Drug Discov., 8, p. 386, DOI: 10.1038/nrd2874 37 10.1038/nrd2874 false true Reference 29942192 /api/reference/29942192 38. Schalla 2020: NUCB2/nesfatin-1-Inhibitory effects on food intake, body weight and metabolism.., Peptides, 128, DOI: 10.1016/j.peptides.2020.170308 38 10.1016/j.peptides.2020.170308 false true Reference 29942193 /api/reference/29942193 39. Schwartz 2000: Central nervous system control of food intake.., Nature, 404, p. 661, DOI: 10.1038/35007534 39 10.1038/35007534 false true Reference 29942194 /api/reference/29942194 40. Shimizu 2009: Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism.., Endocrinology, 150, p. 662, DOI: 10.1210/en.2008-0598 40 10.1210/en.2008-0598 false true Reference 29942195 /api/reference/29942195 41. Su 2010: The novel function of nesfatin-1: anti-hyperglycemia.., Biochem. Biophys. Res. Commun., 391, p. 1039, DOI: 10.1016/j.bbrc.2009.12.014 41 10.1016/j.bbrc.2009.12.014 false true Reference 29942196 /api/reference/29942196 42. Timper 2017: Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity.., Dis. Model. Mech., 10, p. 679, DOI: 10.1242/dmm.026609 42 10.1242/dmm.026609 false true Reference 29942197 /api/reference/29942197 43. Toth 2007: Simultaneous visualization of multiple antigens with tyramide signal amplification using antibodies from the same species.., J. Histochem. Cytochem., 55, p. 545, DOI: 10.1369/jhc.6A7134.2007 43 10.1369/jhc.6A7134.2007 false true Reference 29942198 /api/reference/29942198 44. Tóth 2008: Chronic repeated restraint stress increases prolactin-releasing peptide/tyrosine-hydroxylase ratio with gender-related differences in the rat brain.., J. Neurochem., 104, p. 653, DOI: 10.1111/j.1471-4159.2007.05069.x 44 10.1111/j.1471-4159.2007.05069.x false true Reference 29942199 /api/reference/29942199 45. Uyama 2004: Neural connections between the hypothalamus and the liver.., Anat. Rec. A Discov. Mol. Cell. Evol. Biol., 280, p. 808, DOI: 10.1002/ar.a.20086 45 10.1002/ar.a.20086 false true Reference 29942200 /api/reference/29942200 46. Vaag 2007: Non-obese patients with type 2 diabetes and prediabetic subjects: distinct phenotypes requiring special diabetes treatment and (or) prevention?., Appl. Physiol. Nutr. Metab., 32, p. 912, DOI: 10.1139/h07-100 46 10.1139/h07-100 false true Reference 29942201 /api/reference/29942201 47. Wang 2014: Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes.., Curr. Diabetes Rev., 10, p. 131, DOI: 10.2174/1573399810666140508121012 47 10.2174/1573399810666140508121012 false true Reference 29942202 /api/reference/29942202 48. Wei 2018: NUCB2/nesfatin-1: expression and functions in the regulation of emotion and stress.., Prog. Neuropsychopharmacol. Biol. Psychiatry, 81, p. 221, DOI: 10.1016/j.pnpbp.2017.09.024 48 10.1016/j.pnpbp.2017.09.024 false true Reference 29942203 /api/reference/29942203 49. Wu 2014: Hypothalamic nesfatin-1/NUCB2 knockdown augments hepatic gluconeogenesis that is correlated with inhibition of mTOR-STAT3 signaling pathway in rats.., Diabetes, 63, p. 1234, DOI: 10.2337/db13-0899 49 10.2337/db13-0899 false true Reference 29942204 /api/reference/29942204 50. Yang 2012: Nesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistance.., Diabetes, 61, p. 1959, DOI: 10.2337/db11-1755 50 10.2337/db11-1755 false true Reference 29942205 /api/reference/29942205 51. Yosten 2009: Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system.., Am. J. Physiol. Regul. Integr. Comp. Physiol., 297, p. R330, DOI: 10.1152/ajpregu.90867.2008 51 10.1152/ajpregu.90867.2008 false true /api/publication/32789125 Durst Máté et al. Hypothalamic Nesfatin-1 Resistance May Underlie the Development of Type 2 Diabetes Mellitus in Maternally Undernourished Non-obese Rats. (2022) FRONTIERS IN NEUROSCIENCE 1662-4548 1662-453X 16<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051107"><a href="/gui2/?type=authors&mode=browse&sel=10051107" target="_blank">Durst Máté (<span class="authorship-author-name">Durst Máté</span> <span class="authorAux-mtmt"> idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024762"><a href="/gui2/?type=authors&mode=browse&sel=10024762" target="_blank">Könczöl Katalin^* (<span class="authorship-author-name">Könczöl Katalin</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074191"><a href="/gui2/?type=authors&mode=browse&sel=10074191" target="_blank">Ocskay Klementina (<span class="authorship-author-name">Ocskay Klementina</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072403"><a href="/gui2/?type=authors&mode=browse&sel=10072403" target="_blank">Sípos Klaudia (<span class="authorship-author-name">Sípos Klaudia</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001362"><a href="/gui2/?type=authors&mode=browse&sel=10001362" target="_blank">Várnai Péter (<span class="authorship-author-name">Várnai Péter</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055055"><a href="/gui2/?type=authors&mode=browse&sel=10055055" target="_blank">Szilvásy-Szabó Anett (<span class="authorship-author-name">Stiftné Szilvásy-Szabó Anett</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete Csaba (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001325"><a href="/gui2/?type=authors&mode=browse&sel=10001325" target="_blank">Tóth Zsuzsanna E. ✉ (<span class="authorship-author-name">Tóth Zsuzsanna</span> <span class="authorAux-mtmt"> Neuromorfológia, neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32789125" target="_blank">Hypothalamic Nesfatin-1 Resistance May Underlie the Development of Type 2 Diabetes Mellitus in Maternally Undernourished Non-obese Rats</a></div> <div> <span class="journal-title">FRONTIERS IN NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-4548">1662-4548</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-453X">1662-453X</a>)</span>: <span class="journal-volume">16</span> <span class="page"> Paper 828571. 12 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fnins.2022.828571" target="_blank" href="https://doi.org/10.3389/fnins.2022.828571"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000780297300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000780297300001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="160659" target="_blank" href="https://real.mtak.hu/160659"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85127989862" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85127989862"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35386592" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35386592&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 10</span> | Independent citation: 8 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32789125&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32789125</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian National Research(Grant Nos. NKFI K115422), Hungarian National Research(KP2021-EGA-25), Ministry of Innovation and Technology of Hungary from the National Research, Development and Inno...(TKP2021-EGA), (K134357) </div> <div class="lastModified">Last Modified: 2025.02.26. 00:17 Gusztáv Ladányi (MTMT API user, admin) </div> <div class="lockedBy">Centrally managed 2024.01.18. 09:31 György Wolf (MTMT Központi admin) </div> </div></div>