https://m2.mtmt.hu/ eng 2026-10-25 18:11 JournalArticle 32786081 ADMIN_APPROVED true Journal Article; Review 0 false 2026-10-22T09:23:44.431+0000 2024-05-06T10:23:40.305+0000 2022-04-19T10:50:11.446+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2025-11-27T12:25:44.811+0000 2024-05-06T10:23:40.533+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Tankova, Tsvetalina Management Strategies for Hyperglycemia Associated with the α-Selective PI3K Inhibitor Alpelisib for the Treatment of Breast Cancer. true true /api/journal/10032813 REVIEWED true false 10032813 false 10032813 true 2072-6694 Journal FOREIGN 14 7 1598 1598 2022 Alpelisib is an α-selective phosphatidylinositol 3-kinase inhibitor used for treating hormone receptor-positive (HR+), human epidermal growth receptor 2-negative (HER2-), PIK3CA-mutated locally advanced or metastatic breast cancer following disease progression on or after endocrine therapy. Hyperglycemia is an on-target effect of alpelisib affecting approximately 60% of treated patients, and sometimes necessitating dose reductions, treatment interruptions, or discontinuation of alpelisib. Early detection of hyperglycemia and timely intervention have a key role in achieving optimal glycemic control and maintaining alpelisib dose intensity to optimize the benefit of this drug. A glycemic support program implemented by an endocrinology-oncology collaborative team may be very useful in this regard. Lifestyle modifications, mainly comprising a reduced-carbohydrate diet, and a designated stepwise, personalized antihyperglycemic regimen, based on metformin, sodium-glucose co-transporter 2 inhibitors, and pioglitazone, are the main tools required to address the insulin-resistant hyperglycemia induced by alpelisib. In this report, based on the consensus of 14 oncologists and seven endocrinologists, we provide guidance for hyperglycemia management strategies before, during, and after alpelisib therapy for HR+, HER2-, PIK3CA-mutated breast cancer, with a focus on a proactive, multidisciplinary approach. true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3390/cancers14071598 47 0 47 42 2 47 45 44 34 47 47 42 42 42 5 0 47 42 47 42 0 3 3 Folyóiratcikk Journal Article 24 46 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi 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true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372987 /api/authorship/101372987 10 0.055555556 false false false Lengyel Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372988 /api/authorship/101372988 11 0.055555556 false false false Marcou Yiola true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372989 /api/authorship/101372989 12 0.055555556 false false false Mazilu Laura true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372990 /api/authorship/101372990 13 0.055555556 false false false Mrinakova Bela true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372991 /api/authorship/101372991 14 0.055555556 false false false Percik Ruth true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372992 /api/authorship/101372992 15 0.055555556 false false false Petrakova Katarina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372993 /api/authorship/101372993 16 0.056 false false false Author 10060070 /api/author/10060070 Rubovszky Gábor true 10060070 true Rubovszky Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372994 /api/authorship/101372994 17 0.055555556 false false false Tokar Margarita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101372995 /api/authorship/101372995 18 0.055555556 false true false Vrdoljak Eduard true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20886662 /api/publicationidentifier/20886662 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true 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10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35406370 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35406370&dopt=Abstract false true Keyword 14218 /api/keyword/14218 true 14218 true Keyword 1516592 /api/keyword/1516592 true true Keyword 1683441 /api/keyword/1683441 true true Keyword 2617580 /api/keyword/2617580 true true SjrRating 11315334 /api/sjrrating/11315334 81 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q1 DIRECT true true /api/publication/32786081 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Tankova Tsvetalina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Senkus Elżbieta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Beloyartseva Maria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Borštnar Simona </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Catrinoiu Doina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Frolova Mona </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hegmane Alinta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Janež Andrej </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Krnić Mladen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lengyel Zoltan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Marcou Yiola </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mazilu Laura </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mrinakova Bela </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Percik Ruth </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Petrakova Katarina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060070"><a href="/gui2/?type=authors&mode=browse&sel=10060070" target="_blank">Rubovszky Gábor (<span class="authorship-author-name">Rubovszky Gábor</span> <span class="authorAux-mtmt"> klinikai onkológia</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tokar Margarita </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vrdoljak Eduard </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32786081" target="_blank">Management Strategies for Hyperglycemia Associated with the α-Selective PI3K Inhibitor Alpelisib for the Treatment of Breast Cancer.</a></div> <div> <span class="journal-title">CANCERS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6694">2072-6694</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">7</span> <span class="page"> Paper 1598. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cancers14071598" target="_blank" href="https://doi.org/10.3390/cancers14071598"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000780651200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000780651200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85127031376" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85127031376"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35406370" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35406370&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 47</span> | Independent citation: 42 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 44 | Number of citations in Scopus:&nbsp;34 | WoS/Scopus assigned:&nbsp;47 | Number of citations with DOI:&nbsp;45 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32786081&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32786081</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2024.05.06. 12:23 Tamás Pirmann (OOI addmin5, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Journal Article; Review</pre> </div></div>