Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions

Farkas, Szidónia [Farkas, Szidónia (Gyógyszerészet), author] Institute of Physiology (UP / UPMS); Molecular nNeuroendocrinology Research Group (UP / SZRC); Szabó, Adrienn [Szabó, Adrienn (Sejtbiológia), author] Institute of Physiology (UP / UPMS); Szentágothai Research Centre (UP); School of PhD Studies (SU); Hegyi, Anita E.; Török, Bibiána [Szocsics-Török, Bibiána (Biológus), author] Institute of Physiology (UP / UPMS); Szentágothai Research Centre (UP); School of PhD Studies (SU); Fazekas, Csilla L. [Fazekas, Csilla Lea (Neurobiológia), author] Institute of Physiology (UP / UPMS); Szentágothai Research Centre (UP); School of PhD Studies (SU); Ernszt, Dávid [Ernszt, Dávid (Élettudományok), author] Institute of Physiology (UP / UPMS); Molecular nNeuroendocrinology Research Group (UP / SZRC); Kovács, Tamás [Kovács, Tamás (Elméleti orvostud...), author] Institute of Physiology (UP / UPMS); Molecular nNeuroendocrinology Research Group (UP / SZRC); Zelena, Dóra ✉ [Zelena, Dóra (Neuroendokrinológia), author] Institute of Physiology (UP / UPMS); Szentágothai Research Centre (UP)

English Survey paper (Journal Article) Scientific
Published: BIOMEDICINES 2227-9059 10 (4) Paper: 861 , 39 p. 2022
  • SJR Scopus - Medicine (miscellaneous): Q1
Identifiers
Fundings:
  • (K141934) Funder: NRDIO
  • (K138763) Funder: NKFIH
  • (K120311) Funder: NKFIH
  • (EFOP-3.6.1.-16-2016-00004) Funder: EFOP
  • “The role of neuro-inflammation in neurodegeneration: from molecules to clinics”(EFOP-3.6.2-16-2017-00008)
  • (TKP2021-EGA-16)
Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and complications of traumatic injury. Previously, it was used mainly as a therapeutic option for influencing the menstrual cycle and treating menopausal symptoms. Unfortunately, hormone replacement therapy might be associated with detrimental side effects, such as increased risk of stroke and breast cancer, raising concerns about its safety. Thus, tissue-selective and non-classical estrogen analogues have become the focus of interest. Here, we review the current knowledge about estrogen effects in a broader sense, and the possibility of using selective estrogen-receptor modulators (SERMs), selective estrogen-receptor downregulators (SERDs), phytoestrogens, and activators of non-genomic estrogen-like signaling (ANGELS) molecules as treatment.
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2025-04-25 19:50