(K141934) Támogató: Hungarian National Research, Development and Innovation Office
(K138763) Támogató: NKFIH
(K120311) Támogató: NKFIH
(EFOP-3.6.1.-16-2016-00004) Támogató: EFOP
“The role of neuro-inflammation in neurodegeneration: from molecules to clinics”(EFOP-3.6.2-16-2017-00008)
(TKP2021-EGA-16)
Estrogen is one of the most important female sex hormones, and is indispensable for
reproduction. However, its role is much wider. Among others, due to its neuroprotective
effects, estrogen protects the brain against dementia and complications of traumatic
injury. Previously, it was used mainly as a therapeutic option for influencing the
menstrual cycle and treating menopausal symptoms. Unfortunately, hormone replacement
therapy might be associated with detrimental side effects, such as increased risk
of stroke and breast cancer, raising concerns about its safety. Thus, tissue-selective
and non-classical estrogen analogues have become the focus of interest. Here, we review
the current knowledge about estrogen effects in a broader sense, and the possibility
of using selective estrogen-receptor modulators (SERMs), selective estrogen-receptor
downregulators (SERDs), phytoestrogens, and activators of non-genomic estrogen-like
signaling (ANGELS) molecules as treatment.