https://m2.mtmt.hu/ eng 2026-04-17 12:44 JournalArticle 32778457 VALIDATED true Funding Agency and Grant Number: Semmelweis University; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765-3/2018/FEKUTSRTAT]; Human Resource Development Operational Program [EFOP-3.6.2-16-2017-00006 LIVE LONGER]; The role of neuro-inflammation in neurodegeneration: from molecules to clinics [EFOP-3.6.2-16-2017-00008]; Economic Development and Innovation Operational Program [GINOP-2.3.2-152016-00048 STAY ALIVE] Funding text: Open access funding provided by Semmelweis University. This work was supported by 20765-3/2018/FEKUTSRTAT, Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary; EFOP-3.6.2-16-2017-00006 LIVE LONGER, Human Resource Development Operational Program; EFOP-3.6.2-16-2017-00008, The role of neuro-inflammation in neurodegeneration: from molecules to clinics and GINOP-2.3.2-152016-00048 STAY ALIVE, Economic Development and Innovation Operational Program. The funding had no role in the design, execution, interpretation, or writing of the study. 0 false 2026-03-11T13:50:27.863+0000 2026-01-29T08:50:46.498+0000 2022-04-10T10:08:34.104+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 2026-03-11T13:45:50.268+0000 2023-06-21T07:37:03.587+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 Admin 10067876 /api/admin/10067876 Gusztáv Ladányi (MTMT API user, admin) Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Zsófia Orbán (MTMT ellenőrzés, admin) Orbán Zsófia true true 2024-10-17T16:10:53.532+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Csekő, Kata true true /api/journal/10016708 REVIEWED BMC PULMONARY MEDICINE 1471-2466 1471-2466 true false 10016708 false 10016708 true 1471-2466 1471-2466 Journal FOREIGN 22 1 131 131 10 2022 Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are often associated with airway fluid acidification. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to impaired bicarbonate secretion contributing to CF airway pathology. Chronic cigarette smoke (CS) -the major cause of COPD- is reported to induce acquired CFTR dysfunction underlying airway acidification and inflammation. We hypothesize that bicarbonate-containing aerosols could be beneficial for patients with CFTR dysfunctions. Thus, we investigated the safety of hypertonic sodium bicarbonate (NaHCO3) inhalation in CS-exposed guinea pigs.Animals were divided into groups inhaling hypertonic NaCl (8.4%) or hypertonic NaHCO3 (8.4%) aerosol for 8 weeks. Subgroups from each treatment groups were further exposed to CS. Respiratory functions were measured at 0 and after 2, 4, 6 and 8 weeks. After 8 weeks blood tests and pulmonary histopathological assessment were performed.Neither smoking nor NaHCO3-inhalation affected body weight, arterial and urine pH, or histopathology significantly. NaHCO3-inhalation did not worsen respiratory parameters. Moreover, it normalized the CS-induced transient alterations in frequency, peak inspiratory flow, inspiratory and expiratory times.Long-term NaHCO3-inhalation is safe in chronic CS-exposed guinea pigs. Our data suggest that bicarbonate-containing aerosols might be carefully applied to CF patients. 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Sz. Patológiai Intézet (SE / AOK / I); Konzerváló Fogászati Klinika (SE / FOK); Molekuláris farmakológia kutatócsoport (PTE / SZKK); Orálbiológiai Tanszék (SE / FOK); Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I) 8 37 6 8 0 true 10097590 10067876 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 101323487 /api/authorship/101323487 Csekő, Kata [Csekő, Kata (Gyógyszertudományok), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 1 0.125 true false false Author 10039772 /api/author/10039772 Kata Csekő (Gyógyszertudományok) Csekő Kata true 10039772 true Csekő Kata true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101323488 /api/authorship/101323488 Hargitai, Dóra [Hargitai, Dóra (patológia), author] II. Department of Pathology (SU / FM / I); Patológiai, Igazságügyi és Biztosítási Orvostan... (SU / FM / I) 2 0.125 false false false Author 10026801 /api/author/10026801 Dóra Hargitai (patológia) Hargitai Dóra true 10026801 true Hargitai Dóra true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101323489 /api/authorship/101323489 Draskóczi, Lilla [Draskóczi, Lilla Gréta (Daganatos megbete...), author] 3 0.125 false false false Author 10090890 /api/author/10090890 Lilla Gréta Draskóczi (Daganatos megbetegedések molekuláris hátterének vizsgálata) Draskóczi Lilla Gréta true true Draskóczi Lilla true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101323490 /api/authorship/101323490 Kéri, Adrienn [Ferencsikné Kéri, Adrienn Krisztina (Gyermekgyógyászat), author] Department of Oral Biology (SU / FD) 4 0.125 false false false Author 10082368 /api/author/10082368 Adrienn Krisztina Ferencsikné Kéri (Gyermekgyógyászat) Ferencsikné Kéri Adrienn Krisztina true true Kéri Adrienn true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101323491 /api/authorship/101323491 Jaikumpun, Pongsiri [Pongsiri, Jaikumpun (orálbiológia), author] Department of Oral Biology (SU / FD) 5 0.125 false false false Author 10064957 /api/author/10064957 Jaikumpun Pongsiri (orálbiológia) Pongsiri Jaikumpun true 10064957 true Jaikumpun Pongsiri true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101323492 /api/authorship/101323492 Kerémi, Beáta [Kerémi, Beáta (Konzerváló Fogász...), author] Department of Conservative Dentistry (SU / FD); Department of Oral Biology (SU / FD) 6 0.125 false false false Author 10018993 /api/author/10018993 Beáta Kerémi (Konzerváló Fogászat, Orálbiológia) Kerémi Beáta true 10018993 true Kerémi Beáta true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101323493 /api/authorship/101323493 Helyes, Zsuzsanna [Helyes, Zsuzsanna (Neurofarmakológia), author] Department of Pharmacology and Pharmacotherapy (UP / UPMS); Molecular Pharmacology Research Group (UP / SZRC) 7 0.125 false false false Author 10001426 /api/author/10001426 Zsuzsanna Helyes (Neurofarmakológia) Helyes Zsuzsanna true 10001426 true Helyes Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 101323494 /api/authorship/101323494 Zsembery, Ákos ✉ [Zsembery, Ákos (Élettan), author] Department of Oral Biology (SU / FD) 8 0.125 false true true Author 10015697 /api/author/10015697 Ákos Zsembery (Élettan) Zsembery Ákos true 10015697 true Zsembery Ákos true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 20868699 /api/publicationidentifier/20868699 DOI: 10.1186/s12890-022-01919-x PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s12890-022-01919-x https://doi.org/10.1186/s12890-022-01919-x false true PublicationIdentifier 20910337 /api/publicationidentifier/20910337 WoS: 000779361300004 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000779361300004 https://www.webofscience.com/wos/woscc/full-record/000779361300004 true true PublicationIdentifier 20910338 /api/publicationidentifier/20910338 Scopus: 85128059348 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85128059348 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85128059348 true true PublicationIdentifier 20868698 /api/publicationidentifier/20868698 PubMed: 35392868 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35392868 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35392868&dopt=Abstract false true PublicationIdentifier 31299418 /api/publicationidentifier/31299418 Other URL: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-01919-x PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-01919-x https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-01919-x false true Classification 12451 /api/classification/12451 Smoking true true Classification 12235 /api/classification/12235 Hypertension true true Keyword 131 /api/keyword/131 PH true 131 true Keyword 8807 /api/keyword/8807 Inhalation true 8807 true Keyword 1005182 /api/keyword/1005182 BICARBONATE true 1005182 true Keyword 1015312 /api/keyword/1015312 COPD true 1015312 true Keyword 1027945 /api/keyword/1027945 cystic fibrosis true 1027945 true Keyword 1669159 /api/keyword/1669159 Airways true true SjrRating 11318136 /api/sjrrating/11318136 sjr:Q2 (2022) Scopus - Pulmonary and Respiratory Medicine BMC PULMONARY MEDICINE 1471-2466 1471-2466 39 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2740 /api/classificationexternal/2740 Scopus - Pulmonary and Respiratory Medicine true 2740 true Q2 DIRECT true true /api/publication/32778457 Csekő Kata et al. Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model.. (2022) BMC PULMONARY MEDICINE 1471-2466 1471-2466 22 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10039772"><a href="/gui2/?type=authors&mode=browse&sel=10039772" target="_blank">Csekő Kata (<span class="authorship-author-name">Csekő Kata</span> <span class="authorAux-mtmt"> Gyógyszertudományok</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026801"><a href="/gui2/?type=authors&mode=browse&sel=10026801" target="_blank">Hargitai Dóra (<span class="authorship-author-name">Hargitai Dóra</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/II. Department of Pathology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090890"><a href="/gui2/?type=authors&mode=browse&sel=10090890" target="_blank">Draskóczi Lilla (<span class="authorship-author-name">Draskóczi Lilla Gréta</span> <span class="authorAux-mtmt"> Daganatos megbetegedések molekuláris hátterének...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082368"><a href="/gui2/?type=authors&mode=browse&sel=10082368" target="_blank">Kéri Adrienn (<span class="authorship-author-name">Ferencsikné Kéri Adrienn Krisztina</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064957"><a href="/gui2/?type=authors&mode=browse&sel=10064957" target="_blank">Jaikumpun Pongsiri (<span class="authorship-author-name">Pongsiri Jaikumpun</span> <span class="authorAux-mtmt"> orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018993"><a href="/gui2/?type=authors&mode=browse&sel=10018993" target="_blank">Kerémi Beáta (<span class="authorship-author-name">Kerémi Beáta</span> <span class="authorAux-mtmt"> Konzerváló Fogászat, Orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Conservative Dentistry; <span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001426"><a href="/gui2/?type=authors&mode=browse&sel=10001426" target="_blank">Helyes Zsuzsanna (<span class="authorship-author-name">Helyes Zsuzsanna</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015697"><a href="/gui2/?type=authors&mode=browse&sel=10015697" target="_blank">Zsembery Ákos ✉ (<span class="authorship-author-name">Zsembery Ákos</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32778457" target="_blank">Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model.</a></div> <div> <span class="journal-title">BMC PULMONARY MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2466">1471-2466</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2466">1471-2466</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">1</span> <span class="page"> Paper 131. 10 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12890-022-01919-x" target="_blank" href="https://doi.org/10.1186/s12890-022-01919-x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000779361300004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000779361300004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85128059348" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85128059348"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35392868" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35392868&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-01919-x" target="_blank" href="https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-01919-x"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pulmonary and Respiratory Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 2</span> | Independent citation: 1 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;2 | Number of citations with DOI:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32778457&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32778457</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (20765–3/2018/FEKUTSRTAT), EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Funder: NRDIO, “The role of neuro-inflammation in neurodegeneration: from molecules to clinics”(EFOP-3.6.2-16-2017-00008), GINOP 2.3.2-15- 2016-00048 </div> <div class="lastModified">Last Modified: 2026.01.29. 09:50 Lilla Gréta Draskóczi (Daganatos megbetegedések molekuláris hátterének vizsgálata) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:10 Gusztáv Ladányi (MTMT API user, admin) Zsófia Orbán (MTMT ellenőrzés, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Semmelweis University; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765-3/2018/FEKUTSRTAT]; Human Resource Development Operational Program [EFOP-3.6.2-16-2017-00006 LIVE LONGER]; The role of neuro-inflammation in neurodegeneration: from molecules to clinics [EFOP-3.6.2-16-2017-00008]; Economic Development an...</pre> </div></div>