https://m2.mtmt.hu/ hun 2026-03-14 14:24 JournalArticle 32778457 VALIDATED true Funding Agency and Grant Number: Semmelweis University; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765-3/2018/FEKUTSRTAT]; Human Resource Development Operational Program [EFOP-3.6.2-16-2017-00006 LIVE LONGER]; The role of neuro-inflammation in neurodegeneration: from molecules to clinics [EFOP-3.6.2-16-2017-00008]; Economic Development and Innovation Operational Program [GINOP-2.3.2-152016-00048 STAY ALIVE] Funding text: Open access funding provided by Semmelweis University. This work was supported by 20765-3/2018/FEKUTSRTAT, Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary; EFOP-3.6.2-16-2017-00006 LIVE LONGER, Human Resource Development Operational Program; EFOP-3.6.2-16-2017-00008, The role of neuro-inflammation in neurodegeneration: from molecules to clinics and GINOP-2.3.2-152016-00048 STAY ALIVE, Economic Development and Innovation Operational Program. The funding had no role in the design, execution, interpretation, or writing of the study. 0 false 2026-03-11T13:50:27.863+0000 2026-01-29T08:50:46.498+0000 2022-04-10T10:08:34.104+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-03-11T13:45:50.268+0000 2023-06-21T07:37:03.587+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:10:53.532+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Csekő, Kata Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model. true true /api/journal/10016708 REVIEWED true false 10016708 false 10016708 true 1471-2466 1471-2466 Journal FOREIGN 22 1 131 131 10 2022 Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are often associated with airway fluid acidification. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to impaired bicarbonate secretion contributing to CF airway pathology. Chronic cigarette smoke (CS) -the major cause of COPD- is reported to induce acquired CFTR dysfunction underlying airway acidification and inflammation. We hypothesize that bicarbonate-containing aerosols could be beneficial for patients with CFTR dysfunctions. Thus, we investigated the safety of hypertonic sodium bicarbonate (NaHCO3) inhalation in CS-exposed guinea pigs.Animals were divided into groups inhaling hypertonic NaCl (8.4%) or hypertonic NaHCO3 (8.4%) aerosol for 8 weeks. Subgroups from each treatment groups were further exposed to CS. Respiratory functions were measured at 0 and after 2, 4, 6 and 8 weeks. After 8 weeks blood tests and pulmonary histopathological assessment were performed.Neither smoking nor NaHCO3-inhalation affected body weight, arterial and urine pH, or histopathology significantly. NaHCO3-inhalation did not worsen respiratory parameters. Moreover, it normalized the CS-induced transient alterations in frequency, peak inspiratory flow, inspiratory and expiratory times.Long-term NaHCO3-inhalation is safe in chronic CS-exposed guinea pigs. Our data suggest that bicarbonate-containing aerosols might be carefully applied to CF patients. 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Sz. Patológiai Intézet (SE / AOK / I); Konzerváló Fogászati Klinika (SE / FOK); Molekuláris farmakológia kutatócsoport (PTE / SZKK); Orálbiológiai Tanszék (SE / FOK); Patológiai, Igazságügyi és Biztosítási Orvostan... 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10039772"><a href="/gui2/?type=authors&mode=browse&sel=10039772" target="_blank">Csekő Kata (<span class="authorship-author-name">Csekő Kata</span> <span class="authorAux-mtmt"> Gyógyszertudományok</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Molekuláris farmakológia kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026801"><a href="/gui2/?type=authors&mode=browse&sel=10026801" target="_blank">Hargitai Dóra (<span class="authorship-author-name">Hargitai Dóra</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090890"><a href="/gui2/?type=authors&mode=browse&sel=10090890" target="_blank">Draskóczi Lilla (<span class="authorship-author-name">Draskóczi Lilla Gréta</span> <span class="authorAux-mtmt"> Daganatos megbetegedések molekuláris hátterének...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082368"><a href="/gui2/?type=authors&mode=browse&sel=10082368" target="_blank">Kéri Adrienn (<span class="authorship-author-name">Ferencsikné Kéri Adrienn Krisztina</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064957"><a href="/gui2/?type=authors&mode=browse&sel=10064957" target="_blank">Jaikumpun Pongsiri (<span class="authorship-author-name">Pongsiri Jaikumpun</span> <span class="authorAux-mtmt"> orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018993"><a href="/gui2/?type=authors&mode=browse&sel=10018993" target="_blank">Kerémi Beáta (<span class="authorship-author-name">Kerémi Beáta</span> <span class="authorAux-mtmt"> Konzerváló Fogászat, Orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Konzerváló Fogászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001426"><a href="/gui2/?type=authors&mode=browse&sel=10001426" target="_blank">Helyes Zsuzsanna (<span class="authorship-author-name">Helyes Zsuzsanna</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Molekuláris farmakológia kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015697"><a href="/gui2/?type=authors&mode=browse&sel=10015697" target="_blank">Zsembery Ákos ✉ (<span class="authorship-author-name">Zsembery Ákos</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32778457" target="_blank">Safety of chronic hypertonic bicarbonate inhalation in a cigarette smoke-induced airway irritation guinea pig model.</a></div> <div> <span class="journal-title">BMC PULMONARY MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2466">1471-2466</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-2466">1471-2466</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">1</span> <span class="page"> Paper 131. 10 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12890-022-01919-x" target="_blank" href="https://doi.org/10.1186/s12890-022-01919-x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000779361300004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000779361300004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85128059348" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85128059348"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35392868" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35392868&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-01919-x" target="_blank" href="https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-01919-x"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pulmonary and Respiratory Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 1 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32778457&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32778457</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (20765–3/2018/FEKUTSRTAT), EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH, “The role of neuro-inflammation in neurodegeneration: from molecules to clinics”(EFOP-3.6.2-16-2017-00008), GINOP 2.3.2-15- 2016-00048 </div> <div class="lastModified">Utolsó módosítás: 2026.01.29. 09:50 Draskóczi Lilla Gréta (Daganatos megbetegedések molekuláris hátterének vizsgálata) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:10 Ladányi Gusztáv (MTMT API user, admin) Orbán Zsófia (MTMT ellenőrzés, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Semmelweis University; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765-3/2018/FEKUTSRTAT]; Human Resource Development Operational Program [EFOP-3.6.2-16-2017-00006 LIVE LONGER]; The role of neuro-inflammation in neurodegeneration: from molecules to clinics [EFOP-3.6.2-16-2017-00008]; Economic Development an...</pre> </div></div>