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      <abstractText>Háttér és cél – Kutatásunk célja volt egy prognózist jósló és terápiás opciót ajánló pontrendszer létrehozása a gerincmetasztázissal érintett betegek számára. Az egyre bôvülô onkoterápiás lehetôségek és a prolongált túlélés miatt egyre gyakrabban foglalkozunk a primer tumor csontáttétei miatt kialakult klinikai tünetek megoldásával. A csigolyaáttétek az okozott neurológiai deficittünetek, illetve a fájdalom által szignifikáns életminôségbeni
csökkenést okozhatnak, és a várható élettartamot is jelentôsen befolyásolhatják. A prognózist megfelelô pontossággal jósló pontrendszer segítségünkre lehet a személyre
szabott gyógyítás megvalósításában.
Módszerek – Retrospektív klinikai vizsgálatot végeztünk az Országos Mentális, Ideggyógyászati és Idegsebészeti Intézetben a 2008 és 2018 között mûtéti úton kezelt
18 év feletti gerincáttétes betegek adataiból. 454 beteg adatait elemeztük. Túlélési analízist (Kaplan–Meier-, log-rank-, Cox-modell) végeztünk, hálózati korrelációs vizsgálat segítségével választottuk ki pontrendszerünk prognosztikai faktorait úgy, hogy a vágópont-analízis során maximáljuk annak C értékét (predikciós képességi indexét).
Eredmények – Multivariáns Cox-analízis eredményeként öt prognosztikai faktort azonosítottunk (a primer tumor típusa, életkor, járóképesség, belszervi áttétek, szérumfehérjeszint). Rendszerünk a 10 éves vizsgált periódusban átlagosan 70,6%-os pontossággal prognosztizált.
Következtetés – Szimptómás, mûtéten átesett, gerincmetasztázisban szenvedô betegek nagy esetszámú, egycentrumos, retrospektív mûtéti adatait felhasználva létrehoztuk
rizikóbecslô rendszerünket, ami segítheti a terápia megválasztását. Rizikókalkulátorunk online is elérhetô az alábbi címen: https://emk.semmelweis.hu/gerincmet.</abstractText>
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          <label>12. Zhao C, et al. Prognostic Significance of a Novel Score Model Based on Preoperative Indicators in Patients with Breast Cancer Spine Metastases (BCSM). Cancer Manag Res 2020;12:11501-13., DOI: https://doi.org/10.2147/CMAR.S273785</label>
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          <label>13. Mezei T, Horvath A, Pollner P, Czigleczki G, Banczerowski P. Research on the predicting power of the revised Tokuhashi system: how much time can surgery give to patients with short life expectancy? Int J Clin Oncol 2020;25(4):755-64., DOI: https://doi.org/10.1007/s10147-019-01612-w</label>
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          <doi>https://doi.org/10.1007/s10147-019-01612-w</doi>
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      <label>Mezei Tamás et al. Új, innovatív prognóziskalkulátor áttétes gerinctumoros betegek számára. (2022) IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE 0019-1442 2498-6208 75 3-4 117-127</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10063651&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10063651&quot; target=&quot;_blank&quot;&gt;Mezei, Tamás ✉&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10083423&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10083423&quot; target=&quot;_blank&quot;&gt;Báskay, János&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10010935&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10010935&quot; target=&quot;_blank&quot;&gt;Pollner, Péter&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; 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target=&quot;_blank&quot; href=&quot;https://doi.org/10.18071/isz.75.0117&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;https://elitmed.hu/kiadvanyaink/ideggyogyaszati-szemle/uj-innovativ-prognoziskalkulator-attetes-gerinctumoros-betegek-szamara&quot; target=&quot;_blank&quot; href=&quot;https://elitmed.hu/kiadvanyaink/ideggyogyaszati-szemle/uj-innovativ-prognoziskalkulator-attetes-gerinctumoros-betegek-szamara&quot;&gt; Kiadónál &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_CLOSED&quot; title=&quot; Zárt &quot;&gt; &lt;a style=&quot;color:black&quot; title=&quot;167005&quot; target=&quot;_blank&quot; href=&quot;http://real.mtak.hu/167005&quot;&gt; REAL &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;001080358300005&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/001080358300005&quot;&gt; 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;&amp;nbsp;&amp;nbsp;&amp;nbsp;
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																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10083423&quot; target=&quot;_blank&quot;&gt;Báskay János
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Báskay János&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; gépi tanulás, hálózatok, túlélés analízis&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Egészségügyi Közszolgálati Kar&quot;&gt;EKK&lt;/span&gt;/Egészségügyi Menedzserképző Központ&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10010935&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10010935&quot; target=&quot;_blank&quot;&gt;Pollner Péter
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Pollner Péter&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Elméleti és matematikai fizika&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Eötvös Loránd Tudományegyetem&quot;&gt;ELTE&lt;/span&gt;/&lt;span title=&quot;Természettudományi Kar&quot;&gt;TTK&lt;/span&gt;/&lt;span title=&quot;Fizikai Intézet&quot;&gt;Fiz_I&lt;/span&gt;/Biológiai Fizika Tanszék&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
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																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023835&quot; target=&quot;_blank&quot;&gt;Horváth Anna
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Horváth Anna&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; belgyógyászat; immunológia; onkológia&lt;/span&gt;)
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;&amp;nbsp;&amp;nbsp;&amp;nbsp;
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																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10077790&quot; target=&quot;_blank&quot;&gt;Nagy Zoltán
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;&amp;nbsp;&amp;nbsp;&amp;nbsp;
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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;32766529&quot; target=&quot;_blank&quot;&gt;Új, innovatív prognóziskalkulátor áttétes gerinctumoros betegek számára&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/0019-1442&quot;&gt;0019-1442&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/2498-6208&quot;&gt;2498-6208&lt;/a&gt;)&lt;/span&gt;:
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	&lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv:
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				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Neurology&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q4&lt;/div&gt;
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Forrás	 Idéző
	
	
    | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk
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		Speciális affiliáció:
			Ideggyógyászati Szemle szerkesztősége 
	&lt;/div&gt;

&lt;div class=&quot;funder&quot;&gt; (Rendszeres PhD Fokozatszerzési Kiválósági Ösztöndíj),    (Kiegészítô Kutatási Kiválósági Ösztöndíj),    Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP   &lt;/div&gt;
&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2025.10.16. 10:17 Szabad Viktória (SE_EKK_Admin5_SZV, admin)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Ellenőrizve a teljes szöveg alapján GT&lt;/pre&gt;

&lt;/div&gt;&lt;/div&gt;</template2>
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