https://m2.mtmt.hu/ eng 2026-10-25 11:05 JournalArticle 32765293 APPROVED true Cited By :3 Export Date: 10 July 2024 Correspondence Address: Huang, L.; Laboratory of Molecular Pharmacology, Hungary; email: lumei.huang@koki.mta.hu Chemicals/CAS: adenosine, 58-61-7 0 false 2026-10-22T08:12:15.844+0000 2025-02-25T23:21:36.680+0000 2022-03-30T11:58:26.358+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-08-26T10:17:54.714+0000 2026-08-26T10:17:54.714+0000 Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:20:19.023+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Huang, L. Glial Purinergic Signaling-Mediated Oxidative Stress (GPOS) in Neuropsychiatric Disorders true true /api/journal/10011773 REVIEWED true false 10011773 false 10011773 true 1942-0900 1942-0994 Journal FOREIGN 2022 1075440 1075440 12 2022 Oxidative stress (OS) has been implicated in the progression of multiple neuropsychiatric disorders, including schizophrenia (SZ), major depressive disorder (MDD), bipolar disorder, and autism. However, whether glial purinergic signaling interaction with oxidative/antioxidative system displays an important role in neuropsychiatric disorders is still unclear. In this review, we firstly summarize the oxidative/antioxidative pathways shared in different glial cells and highlight the cell type-specific difference in response to OS. Then, we collect the evidence showing the regulation of purinergic signaling in OS with an emphasis on adenosine and its receptors, P2Y1 receptor in the P2Y family and P2X7receptor in the P2X family. Available data shows that the activation of P1 receptors and P2X accelerates the OS; reversely, the activation of the P2Y family (P2Y1) causes protective effect against OS. Finally, we discuss current findings demonstrating the contribution of the purinergic signaling system to neuropsychiatric disorders and point out the potential role of OS in this process to propose a “glial purinergic-oxidative stress” (“GPOS”) hypothesis for future development of therapeutic strategies against a variety of neuropsychiatric disorders. 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Kísérleti Orvostudományi Kutatóintézet; Molekuláris Farmakológia Kutatócsoport (HRN KOKI) 2 12 3 3 0 false 10066925 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 101215559 /api/authorship/101215559 1 0.333 true false true Author 10070293 /api/author/10070293 Huang Lumei true true Huang L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101215560 /api/authorship/101215560 2 0.33333334 false false false Tang Y. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101215561 /api/authorship/101215561 3 0.333 false true false Author 10008942 /api/author/10008942 Sperlágh Beáta true 10008942 true Sperlagh B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20834896 /api/publicationidentifier/20834896 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1155/2022/1075440 https://doi.org/10.1155/2022/1075440 false true PublicationIdentifier 20928257 /api/publicationidentifier/20928257 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000780820800001 https://www.webofscience.com/wos/woscc/full-record/000780820800001 true true PublicationIdentifier 23146076 /api/publicationidentifier/23146076 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true 160665 https://real.mtak.hu/160665 false true PublicationIdentifier 20834895 /api/publicationidentifier/20834895 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85126416319 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85126416319 false true PublicationIdentifier 20834901 /api/publicationidentifier/20834901 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35281471 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35281471&dopt=Abstract false true Classification 12184 /api/classification/12184 true true UploadedFile 482598 /api/uploadedfile/482598 true false true SjrRating 11283071 /api/sjrrating/11283071 79 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true Q1 DIRECT true true /api/publication/32765293 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10070293"><a href="/gui2/?type=authors&mode=browse&sel=10070293" target="_blank">Huang L. ✉ (<span class="authorship-author-name">Huang Lumei</span> <span class="authorAux-mtmt"> Institute of experimental medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tang Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh B. (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology; Institute of Experimental Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32765293" target="_blank">Glial Purinergic Signaling-Mediated Oxidative Stress (GPOS) in Neuropsychiatric Disorders</a></div> <div> <span class="journal-title">OXIDATIVE MEDICINE AND CELLULAR LONGEVITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0900">1942-0900</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0994">1942-0994</a>)</span>: <span class="journal-volume">2022</span> <span class="page"> Paper 1075440. 12 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1155/2022/1075440" target="_blank" href="https://doi.org/10.1155/2022/1075440"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000780820800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000780820800001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="160665" target="_blank" href="https://real.mtak.hu/160665"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85126416319" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85126416319"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35281471" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35281471&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 5 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;6 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32765293&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32765293</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (OTKA 131629), Horizon 2020 Framework Programme(H2020 766124) </div> <div class="lastModified">Last Modified: 2025.02.26. 00:21 Gusztáv Ladányi (MTMT API user, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:20 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :3 Export Date: 10 July 2024 Correspondence Address: Huang, L.; Laboratory of Molecular Pharmacology, Hungary; email: lumei.huang@koki.mta.hu Chemicals/CAS: adenosine, 58-61-7</pre> </div></div>