https://m2.mtmt.hu/ hun 2026-05-30 12:50 JournalArticle 32759941 VALIDATED true Funding Agency and Grant Number: European Union [EC-GA 603266]; Berlin Institute of Health; Rigshospitalet of the University of Copenhagen; Centre of Research Excellence grant from the British Heart Foundation [RE/18/6/34217]; Radiomics Priority Program grants [DE 1361/19-1 [428222922], DE 1361/20-1 [428223139], SPP2177/1]; German Research Foundation [GRK 2260/1 [289347353]] Funding text: Supported by a grant (EC-GA 603266) from the European Union Seventh Framework Program, a Digital Health Accelerator grant from the Berlin Institute of Health, a grant from Rigshospitalet of the University of Copenhagen, a Centre of Research Excellence grant (RE/18/6/34217) from the British Heart Foundation, and Radiomics Priority Program grants (DE 1361/19-1 [428222922] and 20-1 [428223139] in SPP2177/1) and a grant (GRK 2260/1 [289347353])for the graduate research training group Biophysical Quantitative Imaging toward Clinical Diagnosis (BIOQIC) from the German Research Foundation. 0 false 2026-05-21T19:01:08.543+0000 2023-03-20T08:15:43.919+0000 2022-03-28T09:13:48.945+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2023-05-10T23:14:59.105+0000 2023-05-10T23:14:59.105+0000 2022-11-22T11:53:01.311+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 2022-11-29T09:39:34.198+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Maurovich-Horvat, Pal CT or Invasive Coronary Angiography in Stable Chest Pain true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 386 17 1591 1602 1591 12 2022 BACKGROUND In the diagnosis of obstructive coronary artery disease (CAD), computed tomography (CT) is an accurate, noninvasive alternative to invasive coronary angiography (ICA). However, the comparative effectiveness of CT and ICA in the management of CAD to reduce the frequency of major adverse cardiovascular events is uncertain. METHODS We conducted a pragmatic, randomized trial comparing CT with ICA as initial diagnostic imaging strategies for guiding the treatment of patients with stable chest pain who had an intermediate pretest probability of obstructive CAD and were referred for ICA at one of 26 European centers. The primary outcome was major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) over 3.5 years. Key secondary outcomes were procedure-related complications and angina pectoris. RESULTS Among 3561 patients (56.2% of whom were women), follow-up was complete for 3523 (98.9%). Major adverse cardiovascular events occurred in 38 of 1808 patients (2.1%) in the CT group and in 52 of 1753 (3.0%) in the ICA group (hazard ratio, 0.70; 95% confidence interval [CI), 0.46 to 1.07; P=0.10). Major procedure-related complications occurred in 9 patients (0.5%) in the CT group and in 33 (1.9%) in the ICA group (hazard ratio, 0.26; 95% CI, 0.13 to 0.55). Angina during the final 4 weeks of follow-up was reported in 8.8% of the patients in the CT group and in 7.5% of those in the ICA group (odds ratio, 1.17; 95% CI, 0.92 to 1.48). CONCLUSIONS Among patients referred for ICA because of stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar in the CT group and the ICA group. 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/api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/32759941 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10019530"><a href="/gui2/?type=authors&mode=browse&sel=10019530" target="_blank">Maurovich-Horvat Pal (<span class="authorship-author-name">Maurovich-Horvat Pál</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Bela (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077102"><a href="/gui2/?type=authors&mode=browse&sel=10077102" target="_blank">Benedek Imre (<span class="authorship-author-name">Benedek Imre-Sándor</span> <span class="authorAux-mtmt"> Invazív kardiológia, Elektrofiziológia, Kardiol...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045643"><a href="/gui2/?type=authors&mode=browse&sel=10045643" target="_blank">Szilveszter Balint (<span class="authorship-author-name">Szilveszter Bálint</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061268"><a href="/gui2/?type=authors&mode=browse&sel=10061268" target="_blank">Drobni Zsofia D. (<span class="authorship-author-name">Drobni Zsófia</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069487"><a href="/gui2/?type=authors&mode=browse&sel=10069487" target="_blank">Boussoussou Melinda (<span class="authorship-author-name">Boussoussou Melinda</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; et al. (81) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">DISCHARGE Trial Grp</span> </div> <div><a target="_blank" href="/api/publication/32759941?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32759941" target="_blank">CT or Invasive Coronary Angiography in Stable Chest Pain</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">386</span> <span class="journal-issue">17</span> <span class="page"> pp 1591-1602 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa2200963" target="_blank" href="https://doi.org/10.1056/NEJMoa2200963"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000764276000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000764276000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85126431437" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85126431437"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35240010" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35240010&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 327</span> | Független: 264 | Függő: 63 | Nem jelölt: 0 | WoS jelölt: 294 | Scopus jelölt:&nbsp;305 | WoS/Scopus jelölt:&nbsp;327 | DOI jelölt:&nbsp;319 (Nem nyilvános:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32759941&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32759941</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2023.03.20. 09:15 Benedek Imre-Sándor (Invazív kardiológia, Elektrofiziológia, Kardiológus, Belgyógyász) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: European Union [EC-GA 603266]; Berlin Institute of Health; Rigshospitalet of the University of Copenhagen; Centre of Research Excellence grant from the British Heart Foundation [RE/18/6/34217]; Radiomics Priority Program grants [DE 1361/19-1 [428222922], DE 1361/20-1 [428223139], SPP2177/1]; German Research Foundation [GRK 2260/1 [289347353]] Funding...</pre> </div></div>