https://m2.mtmt.hu/ hun 2026-09-23 12:36 JournalArticle 32707475 VALIDATED true 0 false 2026-09-11T13:31:53.376+0000 2025-08-21T11:35:58.364+0000 2022-02-25T16:51:18.888+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin Sonnevend Kinga (SE_AOK_Adm5_Élet_kutcsop, admin) true 10035718 2025-08-21T11:35:52.669+0000 2025-08-21T11:35:52.669+0000 2025-08-21T11:35:58.533+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin Berhidi Anna (SE_KK_Admin5_BA, admin) true 10015546 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Simon, Dorottya Anna true true /api/journal/10031024 REVIEWED ELIFE 2050-084X true false 10031024 false 10031024 true 2050-084X Journal FOREIGN 11 e69504 e69504 19 2022 Prime editing is a recently developed CRISPR/Cas9 based gene engineering tool that allows the introduction of short insertions, deletions, and substitutions into the genome. However, the efficiency of prime editing, which typically achieves editing rates of around 10%-30%, has not matched its versatility. Here, we introduce the prime editor activity reporter (PEAR), a sensitive fluorescent tool for identifying single cells with prime editing activity. PEAR has no background fluorescence and specifically indicates prime editing events. Its design provides apparently unlimited flexibility for sequence variation along the entire length of the spacer sequence, making it uniquely suited for systematic investigation of sequence features that influence prime editing activity. The use of PEAR as an enrichment marker for prime editing can increase the edited population by up to 84%, thus significantly improving the applicability of prime editing for basic research and biotechnological applications. Funding 2011682 /api/funding/2011682 (K134968) false true Funding 2011683 /api/funding/2011683 (K128188) false true Funding 2011684 /api/funding/2011684 (PD134858) Támogató: OTKA false true Funding 2011685 /api/funding/2011685 (2018-1.1.1-MKI-2018-00167) false true Funding 2011686 /api/funding/2011686 (ÚNKP-20-5-SE-20) Támogató: ÚNKP false true Funding 2011687 /api/funding/2011687 (BO/764/20) Támogató: Bolyai János Kutatási Ösztöndíj false true true NATIONAL 2022 true true true false true false GOLD 2026-09-11 true https://doi.org/10.7554/eLife.69504 31 0 31 26 4 31 31 29 31 31 31 26 26 26 5 0 31 26 31 26 0 3 3 Folyóiratcikk Journal Article 24 31 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 5 4 5 4 2023 0 10 9 10 9 2024 0 8 8 8 8 2025 0 5 4 5 4 2026 0 3 1 3 1 D1 false 10001345,10055848,10038471 false false false 2022-03-24T07:31:21.810+0000 Biokémiai Intézet (HRN SZBK); Doktori Iskola (SE); Enzimológiai Intézet (TTK); Génreguláció Kutatócsoport (HRN TTK / MÉI) 7 31 4 7 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 100838045 /api/authorship/100838045 Simon, Dorottya Anna [Simon, Dorottya Anna (géntechnológia), szerző] Enzimológiai Intézet (TTK); Doktori Iskola (SE) 1 0.143 true false false Author 10081107 /api/author/10081107 Simon Dorottya Anna (géntechnológia) Simon Dorottya Anna true true Simon Dorottya Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100838046 /api/authorship/100838046 Tálas, András* ✉ [Tálas, András (Molekuláris Biológus), szerző] Enzimológiai Intézet (TTK) 2 0.143 true false true Author 10055848 /api/author/10055848 Tálas András (Molekuláris Biológus) Tálas András true 10055848 true Tálas András true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100838047 /api/authorship/100838047 Kulcsár, Péter István [Kulcsár, Péter István (Molekuláris biológia), szerző] Enzimológiai Intézet (TTK) 3 0.143 false false false Author 10038471 /api/author/10038471 Kulcsár Péter István (Molekuláris biológia) Kulcsár Péter István true 10038471 true Kulcsár Péter István true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100838048 /api/authorship/100838048 Biczók, Zsuzsanna [Biczók, Zsuzsanna (biológia), szerző] Doktori Iskola (SE); Génreguláció Kutatócsoport (HRN TTK / MÉI) 4 0.14285715 false false false Author 10085279 /api/author/10085279 Biczók Zsuzsanna (biológia) Biczók Zsuzsanna true true Biczók Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100838049 /api/authorship/100838049 Krausz, Sarah Laura [Krausz, Sarah (géntechnológia), szerző] Doktori Iskola (SE) 5 0.143 false false false Author 10061281 /api/author/10061281 Krausz Sarah (géntechnológia) Krausz Sarah true 10061281 true Krausz Sarah Laura true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100838050 /api/authorship/100838050 Várady, György [Várady, György (Membránbiológia), szerző] Enzimológiai Intézet (TTK) 6 0.143 false false false Author 10015754 /api/author/10015754 Várady György (Membránbiológia) Várady György true 10015754 true Várady György true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100838051 /api/authorship/100838051 Welker, Ervin ✉ [Welker, Ervin (Fehérje feltekeredés), szerző] Biokémiai Intézet (HRN SZBK); Enzimológiai Intézet (TTK) 7 0.143 false true true Author 10001345 /api/author/10001345 Welker Ervin (Fehérje feltekeredés) Welker Ervin true 10001345 true Welker Ervin true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 20697582 /api/publicationidentifier/20697582 DOI: 10.7554/eLife.69504 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.7554/eLife.69504 https://doi.org/10.7554/eLife.69504 false true PublicationIdentifier 20789084 /api/publicationidentifier/20789084 WoS: 000763416100001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000763416100001 https://www.webofscience.com/wos/woscc/full-record/000763416100001 false true PublicationIdentifier 21718763 /api/publicationidentifier/21718763 REAL: 149537 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true 149537 https://real.mtak.hu/149537 false true PublicationIdentifier 20813798 /api/publicationidentifier/20813798 Scopus: 85125590277 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85125590277 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85125590277 false true PublicationIdentifier 20789085 /api/publicationidentifier/20789085 PubMed: 35196219 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35196219 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35196219&dopt=Abstract false true SjrRating 11282715 /api/sjrrating/11282715 sjr:D1 (2022) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) ELIFE 2050-084X 2050-084X 14 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true D1 DIRECT true true Reference 28614353 /api/reference/28614353 1. Anzalone 2019: Search-and-replace genome editing without double-strand breaks or donor DNA., Nature, 576, p. 149, DOI: 10.1038/s41586-019-1711-4 1 10.1038/s41586-019-1711-4 false true Reference 28614354 /api/reference/28614354 2. Bosch 2020: Precise Genome Engineering in Drosophila Using Prime Editing., Genetics, 1, DOI: 10.1101/2020.08.05.232348 2 10.1101/2020.08.05.232348 false true Reference 28614355 /api/reference/28614355 3. Brinkman 2014: Easy quantitative assessment of genome editing by sequence trace decomposition., Nucleic Acids Research, 42, DOI: 10.1093/nar/gku936 3 10.1093/nar/gku936 false true Reference 28614356 /api/reference/28614356 4. Chen 2021: Enhanced prime editing systems by manipulating cellular determinants of editing outcomes., Cell, 184, p. 5635, DOI: 10.1016/j.cell.2021.09.018 4 10.1016/j.cell.2021.09.018 false true Reference 28614357 /api/reference/28614357 5. Coelho 2018: BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B., BMC Biology, 16, DOI: 10.1186/s12915-018-0617-1 5 10.1186/s12915-018-0617-1 false true Reference 28614358 /api/reference/28614358 6. Cong 2013: Multiplex genome engineering using CRISPR/Cas systems., Science (New York, N.Y.), 339, p. 819, DOI: 10.1126/science.1231143 6 10.1126/science.1231143 false true Reference 28614359 /api/reference/28614359 7. Gaudelli 2017: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage., Nature, 551, p. 464, DOI: 10.1038/nature24644 7 10.1038/nature24644 false true Reference 28614360 /api/reference/28614360 8. Gaudelli 2020: Directed evolution of adenine base editors with increased activity and therapeutic application., Nature Biotechnology, 38, p. 892, DOI: 10.1038/s41587-020-0491-6 8 10.1038/s41587-020-0491-6 false true Reference 28614361 /api/reference/28614361 9. Gehrke 2018: An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities., Nature Biotechnology, 36, p. 977, DOI: 10.1038/nbt.4199 9 10.1038/nbt.4199 false true Reference 28614362 /api/reference/28614362 10. Grav 2015: One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment., Biotechnology Journal, 10, p. 1446, DOI: 10.1002/biot.201500027 10 10.1002/biot.201500027 false true Reference 28614363 /api/reference/28614363 11. Huang 2019: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors., Nature Biotechnology, 37, p. 626, DOI: 10.1038/s41587-019-0134-y 11 10.1038/s41587-019-0134-y false true Reference 28614364 /api/reference/28614364 12. Jiang 2020: Prime editing efficiently generates W542L and S621I double mutations in two ALS genes in maize., Genome Biology, 21, p. 1, DOI: 10.1186/s13059-020-02170-5 12 10.1186/s13059-020-02170-5 false true Reference 28614365 /api/reference/28614365 13. Katti 2020: GO: a functional reporter system to identify and enrich base editing activity., Nucleic Acids Research, 48, p. 2841, DOI: 10.1093/nar/gkaa124 13 10.1093/nar/gkaa124 false true Reference 28614366 /api/reference/28614366 14. Kim 2015: Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells., Nature Methods, 12, p. 237, DOI: 10.1038/nmeth.3284 14 10.1038/nmeth.3284 false true Reference 28614367 /api/reference/28614367 15. Kim 2017: Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions., Nature Biotechnology, 35, p. 371, DOI: 10.1038/nbt.3803 15 10.1038/nbt.3803 false true Reference 28614368 /api/reference/28614368 16. Kim 2020: Unbiased investigation of specificities of prime editing systems in human cells., Nucleic Acids Research, 48, p. 10576, DOI: 10.1093/nar/gkaa764 16 10.1093/nar/gkaa764 false true Reference 28614369 /api/reference/28614369 17. Kim 2021: Predicting the efficiency of prime editing guide RNAs in human cells., Nature Biotechnology, 39, p. 198, DOI: 10.1038/s41587-020-0677-y 17 10.1038/s41587-020-0677-y false true Reference 28614370 /api/reference/28614370 18. Kleinstiver 2016: High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects., Nature, 529, p. 490, DOI: 10.1038/nature16526 18 10.1038/nature16526 false true Reference 28614371 /api/reference/28614371 19. Kleinstiver 2016: Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells., Nature Biotechnology, 34, p. 869, DOI: 10.1038/nbt.3620 19 10.1038/nbt.3620 false true Reference 28614372 /api/reference/28614372 20. Koblan 2018: Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction., Nature Biotechnology, 36, p. 843, DOI: 10.1038/nbt.4172 20 10.1038/nbt.4172 false true Reference 28614373 /api/reference/28614373 21. Komor 2016: Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage., Nature, 533, p. 420, DOI: 10.1038/nature17946 21 10.1038/nature17946 false true Reference 28614374 /api/reference/28614374 22. Komor 2017: Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity., Science Advances, 3, DOI: 10.1126/sciadv.aao4774 22 10.1126/sciadv.aao4774 false true Reference 28614375 /api/reference/28614375 23. Kulcsár 2017: Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage., Genome Biology, 18, DOI: 10.1186/s13059-017-1318-8 23 10.1186/s13059-017-1318-8 false true Reference 28614376 /api/reference/28614376 24. Kulcsár 2020: Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5’G-extended sgRNAs., Nature Communications, 11, p. 1, DOI: 10.1038/s41467-020-15021-5 24 10.1038/s41467-020-15021-5 false true Reference 28614377 /api/reference/28614377 25. Kurt 2021: CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells., Nature Biotechnology, 39, p. 41, DOI: 10.1038/s41587-020-0609-x 25 10.1038/s41587-020-0609-x false true Reference 28614378 /api/reference/28614378 26. Lin 2020: Prime genome editing in rice and wheat., Nature Biotechnology, 38, p. 582, DOI: 10.1038/s41587-020-0455-x 26 10.1038/s41587-020-0455-x false true Reference 28614379 /api/reference/28614379 27. Liu 2020: Efficient generation of mouse models with the prime editing system., Cell Discovery, 6, DOI: 10.1038/s41421-020-0165-z 27 10.1038/s41421-020-0165-z false true Reference 28614380 /api/reference/28614380 28. Lu 2021: Precise genome modification in tomato using an improved prime editing system., Plant Biotechnology Journal, 19, p. 415, DOI: 10.1111/pbi.13497 28 10.1111/pbi.13497 false true Reference 28614381 /api/reference/28614381 29. Mali 2013: RNA-guided human genome engineering via Cas9., Science (New York, N.Y.), 339, p. 823, DOI: 10.1126/science.1232033 29 10.1126/science.1232033 false true Reference 28614382 /api/reference/28614382 30. Martin 2019: A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes., Scientific Reports, 9, p. 1, DOI: 10.1038/s41598-018-36739-9 30 10.1038/s41598-018-36739-9 false true Reference 28614383 /api/reference/28614383 31. Ramakrishna 2014: Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations., Nature Communications, 5, p. 1, DOI: 10.1038/ncomms4378 31 10.1038/ncomms4378 false true Reference 28614384 /api/reference/28614384 32. Schene 2020: Prime editing for functional repair in patient-derived disease models., Nature Communications, 11, p. 1, DOI: 10.1038/s41467-020-19136-7 32 10.1038/s41467-020-19136-7 false true Reference 28614385 /api/reference/28614385 33. St Martin 2018: A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells., Nucleic Acids Research, 46, DOI: 10.1093/nar/gky332 33 10.1093/nar/gky332 false true Reference 28614386 /api/reference/28614386 34. Standage-Beier 2019: A transient reporter for editing enrichment (TREE) in human cells., Nucleic Acids Research, 47, DOI: 10.1093/nar/gkz713 34 10.1093/nar/gkz713 false true Reference 28614387 /api/reference/28614387 35. Sürün 2020: Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors., Genes, 11, DOI: 10.3390/genes11050511 35 10.3390/genes11050511 false true Reference 28614388 /api/reference/28614388 36. Tálas 2021: BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors., Nature Communications, 12, p. 1, DOI: 10.1038/s41467-021-26461-y 36 10.1038/s41467-021-26461-y false true Reference 28614389 /api/reference/28614389 37. Trojan 2002: Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system., Gastroenterology, 122, p. 211, DOI: 10.1053/gast.2002.30296 37 10.1053/gast.2002.30296 false true Reference 28614390 /api/reference/28614390 38. Tsai 2015: GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases., Nature Biotechnology, 33, p. 187, DOI: 10.1038/nbt.3117 38 10.1038/nbt.3117 false true Reference 28614391 /api/reference/28614391 39. Tsai 2016: Open-source guideseq software for analysis of GUIDE-seq data., Nature Biotechnology, 34, DOI: 10.1038/nbt.3534 39 10.1038/nbt.3534 false true Reference 28614392 /api/reference/28614392 40. Tsai 2017: CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets., Nature Methods, 14, p. 607, DOI: 10.1038/nmeth.4278 40 10.1038/nmeth.4278 false true Reference 28614393 /api/reference/28614393 41. Vriend 2014: Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases., Methods in Enzymology, 546, p. 175, DOI: 10.1016/B978-0-12-801185-0.00009-X 41 10.1016/B978-0-12-801185-0.00009-X false true Reference 28614394 /api/reference/28614394 42. Wang 2013: One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering., Cell, 153, p. 910, DOI: 10.1016/j.cell.2013.04.025 42 10.1016/j.cell.2013.04.025 false true Reference 28614395 /api/reference/28614395 43. Wang 2020: BEON: A Functional Fluorescence Reporter for Quantification and Enrichment of Adenine Base-Editing Activity., Molecular Therapy, 28, p. 1696, DOI: 10.1016/j.ymthe.2020.04.009 43 10.1016/j.ymthe.2020.04.009 false true Reference 28614396 /api/reference/28614396 44. Xu 2020: Versatile Nucleotides Substitution in Plant Using an Improved Prime Editing System., Molecular Plant, 13, p. 675, DOI: 10.1016/j.molp.2020.03.012 44 10.1016/j.molp.2020.03.012 false true Reference 28614397 /api/reference/28614397 45. Yan 2020: A Universal Surrogate Reporter for Efficient Enrichment of CRISPR/Cas9-Mediated Homology-Directed Repair in Mammalian Cells., Molecular Therapy. Nucleic Acids, 19, p. 775, DOI: 10.1016/j.omtn.2019.12.021 45 10.1016/j.omtn.2019.12.021 false true Reference 28614398 /api/reference/28614398 46. Zafra 2018: Optimized base editors enable efficient editing in cells, organoids and mice., Nature Biotechnology, 36, p. 888, DOI: 10.1038/nbt.4194 46 10.1038/nbt.4194 false true Reference 28614399 /api/reference/28614399 47. Zhao 2021: Glycosylase base editors enable C-to-A and C-to-G base changes., Nature Biotechnology, 39, p. 35, DOI: 10.1038/s41587-020-0592-2 47 10.1038/s41587-020-0592-2 false true /api/publication/32707475 Simon Dorottya Anna et al. PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells. (2022) ELIFE 2050-084X 11<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10081107"><a href="/gui2/?type=authors&mode=browse&sel=10081107" target="_blank">Simon Dorottya Anna (<span class="authorship-author-name">Simon Dorottya Anna</span> <span class="authorAux-mtmt"> géntechnológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055848"><a href="/gui2/?type=authors&mode=browse&sel=10055848" target="_blank">Tálas András^* ✉ (<span class="authorship-author-name">Tálas András</span> <span class="authorAux-mtmt"> Molekuláris Biológus</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038471"><a href="/gui2/?type=authors&mode=browse&sel=10038471" target="_blank">Kulcsár Péter István (<span class="authorship-author-name">Kulcsár Péter István</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085279"><a href="/gui2/?type=authors&mode=browse&sel=10085279" target="_blank">Biczók Zsuzsanna (<span class="authorship-author-name">Biczók Zsuzsanna</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Génreguláció Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061281"><a href="/gui2/?type=authors&mode=browse&sel=10061281" target="_blank">Krausz Sarah Laura (<span class="authorship-author-name">Krausz Sarah</span> <span class="authorAux-mtmt"> géntechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady György (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001345"><a href="/gui2/?type=authors&mode=browse&sel=10001345" target="_blank">Welker Ervin ✉ (<span class="authorship-author-name">Welker Ervin</span> <span class="authorAux-mtmt"> Fehérje feltekeredés</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet; <span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32707475" target="_blank">PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells</a></div> <div> <span class="journal-title">ELIFE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-084X">2050-084X</a>)</span>: <span class="journal-volume">11</span> <span class="page"> Paper e69504. 19 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.7554/eLife.69504" target="_blank" href="https://doi.org/10.7554/eLife.69504"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000763416100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000763416100001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="149537" target="_blank" href="https://real.mtak.hu/149537"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85125590277" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85125590277"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35196219" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35196219&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 31</span> | Független: 26 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 29 | Scopus jelölt:&nbsp;31 | WoS/Scopus jelölt:&nbsp;31 | DOI jelölt:&nbsp;31 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32707475&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32707475</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K134968), (K128188), (PD134858) Támogató: OTKA, (2018-1.1.1-MKI-2018-00167), (ÚNKP-20-5-SE-20) Támogató: ÚNKP, (BO/764/20) Támogató: Bolyai János Kutatási Ösztöndíj </div> <div class="lastModified">Utolsó módosítás: 2025.08.21. 13:35 Berhidi Anna (SE_KK_Admin5_BA, admin) </div> </div></div>