https://m2.mtmt.hu/ hun 2026-10-25 17:03 JournalArticle 32695038 VALIDATED true Department of Radiobiology and Diagnostic Onco-Cytogenetics, Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary Semmelweis University, Faculty of Medicine, Department of Oncology, Budapest, Hungary National Koranyi Institute of Pulmonology, Budapest, Hungary Export Date: 25 September 2024; Cited By: 1; Correspondence Address: Z. Takácsi-Nagy; Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary; email: takacsi-nagy.zoltan@med.semmelweis-univ.hu 0 false 2026-10-22T05:38:24.960+0000 2022-11-16T10:25:54.603+0000 2022-02-21T13:49:50.025+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2025-01-16T10:21:54.966+0000 2022-11-16T10:25:54.618+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080105 /api/admin/10080105 Kériné Tornyi Katalin true true 2024-10-17T16:16:12.275+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kocsis, Zsuzsa S Chromosomal Aberrations in Blood Lymphocytes as Predictors of Respiratory Function After Stereotactic Lung Irradiation true true /api/journal/10025358 REVIEWED true false 10025358 false 10025358 true 2234-943X 2234-943X Journal FOREIGN 11 829972 829972 9 2022 Due to the profound difference in radiosensitivity of patients and various side effects caused by this phenomenon, a radiosensitivity marker is needed. Prediction by a marker may help personalise the treatment. In this study, we tested chromosomal aberrations (CA) of in vitro irradiated blood as predictor of pulmonary function decrease of nonsmall cell lung cancer (NSCLC) patients and also compared it with the CAs in the blood of irradiated patients. Peripheral blood samples were taken from 45 lung cancer patients before stereotactic radiotherapy (SBRT) and immediately after the last fraction and 3, 6, 9, 12, 15, 18, 21, and 24 months later. Respiratory function measurements were performed at the same time. Diffusing capacity of lung for carbon monoxide (DLCO), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1s), and FEV1s/FVC (FEV1%) were monitored. Metaphase preparations of lymphocytes were made with standard procedures, and chromosome aberrations were analysed. In our cohort, the 36-month local relapse-free survival was 97.4%, and the distant metastasis-free survival was 71.5% at 36 months. There was no change in the mean of the pulmonary function tests (PFTs) after the therapy. However, there was a considerable variability between the patients. Therefore, we subtracted the baseline and normalised the PFT values. There were significant decreases at 12-24 months in relative FEV1s and relative FEV1%. The tendentious decrease of the PFTs could be predicted by the in vitro chromosome aberration data. We also found connections between the in vitro and in vivo CA values (i.e., dicentrics plus rings after 3 Gy irradiation predicts dicentric-plus-ring value directly after the radiotherapy/V54 Gy (p = 0.001 24.2%)). We found that-after further validation-chromosome aberrations resulted from in vitro irradiation before radiotherapy can be a predictive marker of pulmonary function decrease after lung irradiation. 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35155217&dopt=Abstract false true Keyword 19309 /api/keyword/19309 true 19309 true Keyword 19546 /api/keyword/19546 true 19546 true Keyword 1011681 /api/keyword/1011681 true 1011681 true Keyword 1266104 /api/keyword/1266104 true 1266104 true Keyword 1464003 /api/keyword/1464003 true 1464003 true Keyword 1640047 /api/keyword/1640047 true true Keyword 2595367 /api/keyword/2595367 true true SjrRating 11283984 /api/sjrrating/11283984 84 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true Q2 DIRECT true true /api/publication/32695038 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020433"><a href="/gui2/?type=authors&mode=browse&sel=10020433" target="_blank">Kocsis Zsuzsa S (<span class="authorship-author-name">Kocsis Zsuzsa</span> <span class="authorAux-mtmt"> sugárbiológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011699"><a href="/gui2/?type=authors&mode=browse&sel=10011699" target="_blank">Farkas Gyöngyi (<span class="authorship-author-name">Farkas Gyöngyi</span> <span class="authorAux-mtmt"> Környezeti mikrobiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057580"><a href="/gui2/?type=authors&mode=browse&sel=10057580" target="_blank">Bajcsay András (<span class="authorship-author-name">Bajcsay András</span> <span class="authorAux-mtmt"> Sugárterápia, Klinikai Onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071423"><a href="/gui2/?type=authors&mode=browse&sel=10071423" target="_blank">Kun-Gazda Márta (<span class="authorship-author-name">Kun-Gazda Márta</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026872"><a href="/gui2/?type=authors&mode=browse&sel=10026872" target="_blank">Lövey József (<span class="authorship-author-name">Lövey József</span> <span class="authorAux-mtmt"> Sugárterápia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ostoros Gyula </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042822"><a href="/gui2/?type=authors&mode=browse&sel=10042822" target="_blank">Pócza Tamás (<span class="authorship-author-name">Pócza Tamás</span> <span class="authorAux-mtmt"> Orvosi fizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042833"><a href="/gui2/?type=authors&mode=browse&sel=10042833" target="_blank">Herein András (<span class="authorship-author-name">Herein András</span> <span class="authorAux-mtmt"> Fizikai</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ladányi Katalin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032265"><a href="/gui2/?type=authors&mode=browse&sel=10032265" target="_blank">Székely Gábor (<span class="authorship-author-name">Székely Gábor</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Markóczy Zsolt </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013883"><a href="/gui2/?type=authors&mode=browse&sel=10013883" target="_blank">Takácsi-Nagy Zoltán ✉ (<span class="authorship-author-name">Takácsi-Nagy Zoltán</span> <span class="authorAux-mtmt"> Sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgár Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010426"><a href="/gui2/?type=authors&mode=browse&sel=10010426" target="_blank">Juranyi Zsolt (<span class="authorship-author-name">Jurányi Zsolt</span> <span class="authorAux-mtmt"> Onkológiai kutatás, sugárterápia, sugárbiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32695038" target="_blank">Chromosomal Aberrations in Blood Lymphocytes as Predictors of Respiratory Function After Stereotactic Lung Irradiation</a></div> <div> <span class="journal-title">FRONTIERS IN ONCOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2234-943X">2234-943X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2234-943X">2234-943X</a>)</span>: <span class="journal-volume">11</span> <span class="page"> Paper 829972. 9 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fonc.2021.829972" target="_blank" href="https://doi.org/10.3389/fonc.2021.829972"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000753156600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000753156600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85124571675" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85124571675"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35155217" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35155217&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 3 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;5 | WoS/Scopus jelölt:&nbsp;6 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32695038&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32695038</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (TKP2020-NKA-26), (National Tumor Biology Laboratory, NLP-17) Támogató: The Hungarian National Laboratories Excellence program, (K-124937) Támogató: OTKA </div> <div class="lastModified">Utolsó módosítás: 2022.11.16. 11:25 Molnár-Taga Márta (SE 4-es admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:16 Ladányi Gusztáv (MTMT API user, admin) Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Radiobiology and Diagnostic Onco-Cytogenetics, Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary Semmelweis University, Faculty of Medicine, Department of Oncology, Budapest, Hungary National Koranyi Institute of ...</pre> </div></div>