Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells

Walter, FR [Walter, Fruzsina (biofizika), author] Institute of Biophysics; Harazin, A [Harazin, András (sejtbiológia), author] Institute of Biophysics; Toth, AE [Tóth, Andrea (neurobiológia), author] Institute of Biophysics; Veszelka, S [Veszelka, Szilvia (Biológiai tudományok), author] Institute of Biophysics; Santa-Maria, AR [Santa Maria, Anaraquel (biofizika), author] Institute of Biophysics; Barna, L [Barna, Lilla (vér-agy gát), author] Institute of Biophysics; Kincses, A [Kincses, András (biofizika), author] Institute of Biophysics; Biczo, G; Balla, Z [Balla, Zsolt (gasztroenterológia), author] Department of Internal Medicine (SZTE / ASZMS); Department of Environmental Biology and Education (SZTE / JGYPK / IHE); Kui, B [Kui, Balázs (Gasztroenterológia), author] Department of Internal Medicine (SZTE / ASZMS); Maleth, J [Maléth, József (Gasztroenterológia), author] Department of Internal Medicine (SZTE / ASZMS); MTA-SZTE Momentum Translational Gastroenterolog... (SZTE / ASZMS / DIMedicine...; MTA-SZTE Momentum Epithelial Cell Signalling an... (SZTE / ASZMS / DIMedicine...; Cervenak, L [Cervenak, László (Immunológia), author] Belgyógyászati és Hematológiai Klinika (SU / FM / C); Tubak, V [Tubak, Vilmos (biokémia), author]; Kittel, A [Kittel, Ágnes (Sejtbiológia), author] Institute of Experimental Medicine; Rakonczay, Zjr [Rakonczay, Zoltán (Gasztroenterológia), author] Department of Internal Medicine (SZTE / ASZMS); Department of Pathophysiology (SZTE / ASZMS); Deli, MA ✉ [Deli, Mária Anna (Neurobiológia, vé...), author] Institute of Biophysics

English Article (Journal Article) Scientific
Published: FLUIDS AND BARRIERS OF THE CNS 2045-8118 2045-8118 19 (1) Paper: 16 , 20 p. 2022
  • SJR Scopus - Developmental Neuroscience: D1
Fundings:
  • (PD‑128480)
  • (K119938)
  • János Bolyai Research Scholarship(BO/00174/18)
  • (PREMIUM‑2019‑469)
Subjects:
  • Gastroenterology and hepatology
  • MEDICAL AND HEALTH SCIENCES
In severe acute pancreatitis (AP) the CNS is affected manifesting in neurological symptoms. Earlier research from our laboratory showed blood–brain barrier (BBB) permeability elevation in a taurocholate-induced AP model. Here we aimed to further explore BBB changes in AP using a different, non-invasive in vivo model induced by l-ornithine. Our goal was also to identify whether l-ornithine, a cationic amino acid, has a direct effect on brain endothelial cells in vitro contributing to the observed BBB changes.
Cited in (24)
Citing (29)
Citation styles: IEEEACMAPAChicagoHarvardCSLCopyPrint
2026-05-21 19:16