https://m2.mtmt.hu/ eng 2026-10-23 20:44 JournalArticle 32660835 APPROVED true 0 false 2026-10-22T08:20:18.672+0000 2025-06-04T15:30:30.059+0000 2022-02-09T12:45:51.849+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-09-03T09:53:09.633+0000 2026-09-03T09:53:09.633+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ecker, András Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3 true true /api/journal/10031024 REVIEWED true false 10031024 false 10031024 true 2050-084X Journal FOREIGN 11 e71850 e71850 29 2022 Hippocampal place cells are activated sequentially as an animal explores its environment. These activity sequences are internally recreated ('replayed'), either in the same or reversed order, during bursts of activity (sharp wave-ripples [SWRs]) that occur in sleep and awake rest. SWR-associated replay is thought to be critical for the creation and maintenance of long-term memory. In order to identify the cellular and network mechanisms of SWRs and replay, we constructed and simulated a data-driven model of area CA3 of the hippocampus. Our results show that the chain-like structure of recurrent excitatory interactions established during learning not only determines the content of replay, but is essential for the generation of the SWRs as well. We find that bidirectional replay requires the interplay of the experimentally confirmed, temporally symmetric plasticity rule, and cellular adaptation. Our model provides a unifying framework for diverse phenomena involving hippocampal plasticity, representations, and dynamics, and suggests that the structured neural codes induced by learning may have greater influence over cortical network states than previously appreciated. 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true true Keyword 1589698 /api/keyword/1589698 true true Keyword 1957123 /api/keyword/1957123 true true SjrRating 11282715 /api/sjrrating/11282715 14 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 true 1301 true D1 DIRECT true true /api/publication/32660835 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10098917"><a href="/gui2/?type=authors&mode=browse&sel=10098917" target="_blank">Ecker András ✉ (<span class="authorship-author-name">Ecker András</span> <span class="authorAux-mtmt"> neurobiológia, bioinformatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bagi Bence </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vértes Eszter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Steinbach-Németh Orsolya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014208"><a href="/gui2/?type=authors&mode=browse&sel=10014208" target="_blank">Karlocai Maria Rita (<span class="authorship-author-name">Karlócai Rita</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Papp Orsolya I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012802"><a href="/gui2/?type=authors&mode=browse&sel=10012802" target="_blank">Miklós István (<span class="authorship-author-name">Miklós István</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Institute for Computer Science and Control">ICSC</span>/Informatics Laboratory</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hájos Norbert (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000275"><a href="/gui2/?type=authors&mode=browse&sel=10000275" target="_blank">Freund Tamás (<span class="authorship-author-name">Freund Tamás</span> <span class="authorAux-mtmt"> Neurobiológia, idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cerebral Cortex Research; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009114"><a href="/gui2/?type=authors&mode=browse&sel=10009114" target="_blank">Gulyás Attila I (<span class="authorship-author-name">Gulyás Attila</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011500"><a href="/gui2/?type=authors&mode=browse&sel=10011500" target="_blank">Káli Szabolcs ✉ (<span class="authorship-author-name">Káli Szabolcs</span> <span class="authorAux-mtmt"> Elméleti neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cerebral Cortex Research; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; Institute of Experimental Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32660835" target="_blank">Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3</a></div> <div> <span class="journal-title">ELIFE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-084X">2050-084X</a>)</span>: <span class="journal-volume">11</span> <span class="page"> Paper e71850. 29 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.7554/eLife.71850" target="_blank" href="https://doi.org/10.7554/eLife.71850"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000763418800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000763418800001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="10329" target="_blank" href="https://eprints.sztaki.hu/10329"> SZTAKI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="154193" target="_blank" href="https://real.mtak.hu/154193"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85123739637" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85123739637"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="35040779" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35040779&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="https://elifesciences.org/articles/71850" target="_blank" href="https://elifesciences.org/articles/71850"> Full text </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 52</span> | Independent citation: 51 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 49 | Number of citations in Scopus:&nbsp;43 | WoS/Scopus assigned:&nbsp;50 | Number of citations with DOI:&nbsp;52 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32660835&sort=publishedYear,desc&sort=title"> Number of cited publications: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32660835</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> MILAB(RRF-2.3.1-21-2022-00004) Funder: NRDIO, Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), Hungarian Scientific Research Fund(K115441) Funder: NKFIH, Hungarian Scientific Research Fund(K83251) Funder: NKFIH, Hungarian Scientific Research Fund(K85659) Funder: NKFIH, Horizon 2020 Framework Programme(720270), Horizon 2020 Framework Programme(785907), European Research Council(ERC-2011-ADG-294313), EU FP7(604102) </div> <div class="lastModified">Last Modified: 2025.06.04. 17:30 Márta Turek (KOKI admin 4) </div> </div></div>