Objective: To investigate the analgesic effect and inflammatory mechanism of nonsteroidal
analgesics combined with nerve block in post-gynecologic surgery patients. Methods:
Sixty patients who underwent gynecological laparotomies in our hospital were enrolled
in this retrospective cohort study, with 30 patients administered nonsteroidal analgesics
combined with nerve block (the observation group) and 30 patients administered nonsteroidal
analgesics alone (the control group). The patients in the observation group were administered
an intravenous injection of flurbiprofen axetil 1 mg/kg before the end of the operation,
and 0.375% ropivacaine was used for bilateral transversus abdominis plane block after
the operation. The patients in the control group were administered only an intravenous
injection of flurbiprofen axetil 1 mg/kg before the end of the operation. The blood
pressure (BP), heart rate (HR), visual analogue scale (VAS) scores, and the numerical
rating scale (NRS) scores were recorded before the operation (T0) and at 1 h (T1),
6 h (T2), 12 h (T3), and 24 h (T4) after the recovery from the anesthesia. The incidences
of emergence agitation, and the operation and recovery times in the two groups were
recorded. Blood samples were collected before and at one day after the operations
to measure the inflammatory factor levels such as IL-6, IL-1 beta, and TNF-alpha.
Results: The BP, HR, and the VAS and NRS scores in the observation group at T1, T2,
T3, and T4 were lower than they were in the control group (P<0.01). The inflammatory
factor levels after the operation in the observation group were lower than they were
in the control group (P<0.01). There was no significant difference in the incidences
of complications between the two groups (P>0.05). Conclusion: Flurbiprofen axetil
combined with ropivacaine for bilateral transversus abdominis plane block has a significant
analgesic effect on patients after gynecologic surgery. The mechanism may be due to
the fact that nonsteroidal analgesics combined with nerve block further reduce the
inflammatory factors in the body, which proves the superiority of multimodal analgesia.
