https://m2.mtmt.hu/ eng 2026-10-25 15:57 JournalArticle 32651528 VALIDATED true 0 false 2026-10-22T03:58:44.731+0000 2022-10-13T06:48:18.995+0000 2022-02-07T09:54:14.486+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2024-03-01T12:02:11.449+0000 2024-03-01T12:02:11.449+0000 2022-10-13T06:48:19.013+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:10:53.532+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Csípő, T. A Central Role for TRPM4 in Ca2+-Signal Amplification and Vasoconstriction true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 23 3 1465 1465 13 2022 Transient receptor potential melastatin-4 (TRPM4) is activated by an increase in intracellular Ca2+ concentration and is expressed on smooth muscle cells (SMCs). It is implicated in the myogenic constriction of cerebral arteries. We hypothesized that TRPM4 has a general role in intracellular Ca2+ signal amplification in a wide range of blood vessels. TRPM4 function was tested with the TRPM4 antagonist 9-phenanthrol and the TRPM4 activator A23187 on the cardiovascular responses of the rat, in vivo and in isolated basilar, mesenteric, and skeletal muscle arteries. TRPM4 inhibition by 9-phenanthrol resulted in hypotension and a decreased heart rate in the rat. TRPM4 inhibition completely antagonized myogenic tone development and norepinephrine-evoked vasoconstriction, and depolarization (high extracellular KCl concentration) evoked vasoconstriction in a wide range of peripheral arteries. Vasorelaxation caused by TRPM4 inhibition was accompanied by a significant decrease in intracellular Ca2+ concentration, suggesting an inhibition of Ca2+ signal amplification. Immunohistochemistry confirmed TRPM4 expression in the smooth muscle cells of the peripheral arteries. Finally, TRPM4 activation by the Ca2+ ionophore A23187 was competitively inhibited by 9-phenanthrol. In summary, TRPM4 was identified as an essential Ca2+-amplifying channel in peripheral arteries, contributing to both myogenic tone and agonist responses. These results suggest an important role for TRPM4 in the circulation. The modulation of TRPM4 activity may be a therapeutic target for hypertension. Furthermore, the Ca2+ ionophore A23187 was identified as the first high-affinity (nanomolar) direct activator of TRPM4, acting on the 9-phenanthrol binding site. Funding 2009111 /api/funding/2009111 false true Funding 2009112 /api/funding/2009112 false true Funding 2009113 /api/funding/2009113 false true Funding 2009114 /api/funding/2009114 false true Funding 2009115 /api/funding/2009115 false true Funding 2009116 /api/funding/2009116 false true true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3390/ijms23031465 14 0 14 12 2 14 14 13 14 14 14 12 12 12 2 0 14 12 14 12 0 0 0 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 2 2 2 2 2024 0 4 2 4 2 2025 0 6 6 6 6 2026 0 1 1 1 1 D1 false 10012492 false false false 2022-02-06T09:58:52.491+0000 Farmakológiai és Farmakoterápiai Intézet (DE / ÁOK); Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK); Gyógyszerészeti Tudományok Doktori Iskola (DE / ODT); Kardiológiai Tanszék (DE / ÁOK / KardI); Laki Kálmán Doktori Iskola (DE / ODT); MTA-DE Vaszkuláris Biológia és Miokardium Patof... (DE / ÁOK); Molekuláris farmakológia kutatócsoport (PTE / SZKK); Népegészségtani Intézet (SE / AOK / I) 13 63 8 14 0 true 10097590 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 100464138 /api/authorship/100464138 1 0.071 true false false Author 10055259 /api/author/10055259 Csípő Tamás true 10055259 true Csípő T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464139 /api/authorship/100464139 2 0.071 false false false Author 10038697 /api/author/10038697 Czikora Ágnes true 10038697 true Czikora Á. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464140 /api/authorship/100464140 3 0.071 false false false Author 10044572 /api/author/10044572 Fülöp Gábor Áron true 10044572 true Fülöp G.Á. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464141 /api/authorship/100464141 4 0.071 false false false Author 10067183 /api/author/10067183 Gulyás Hajnalka true true Gulyás H. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464142 /api/authorship/100464142 5 0.071 false false false Author 10038698 /api/author/10038698 Rutkai Ibolya DUPLUM true 10038698 true Rutkai I. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464143 /api/authorship/100464143 6 0.071 false false false Author 10038727 /api/author/10038727 Pásztorné Tóth Enikő true 10038727 true Tóth E.P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464144 /api/authorship/100464144 7 0.071 false false false Author 10012492 /api/author/10012492 Pórszász Róbert true 10012492 true Pórszász R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464145 /api/authorship/100464145 8 0.071428575 false false false Szalai A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464146 /api/authorship/100464146 9 0.071428575 false false false Author 10017552 /api/author/10017552 Bölcskei Kata true 10017552 true Bölcskei K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464147 /api/authorship/100464147 10 0.071428575 false false false Author 10001426 /api/author/10001426 Helyes Zsuzsanna true 10001426 true Helyes Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464148 /api/authorship/100464148 11 0.071428575 false false false Author 10012367 /api/author/10012367 Pintér Erika true 10012367 true Pintér E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464149 /api/authorship/100464149 12 0.071 false false false Author 10000066 /api/author/10000066 Papp Zoltán true 10000066 true Papp Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464150 /api/authorship/100464150 13 0.071 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvári Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100464151 /api/authorship/100464151 14 0.071 false true true Author 10003186 /api/author/10003186 Tóth Attila true 10003186 true Tóth A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20544460 /api/publicationidentifier/20544460 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms23031465 https://doi.org/10.3390/ijms23031465 false true PublicationIdentifier 20719519 /api/publicationidentifier/20719519 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35163382&dopt=Abstract false true Classification 12124 /api/classification/12124 true true Keyword 1045754 /api/keyword/1045754 true 1045754 true Keyword 1047262 /api/keyword/1047262 true 1047262 true Keyword 1505118 /api/keyword/1505118 true true Keyword 1757855 /api/keyword/1757855 true true Keyword 2739306 /api/keyword/2739306 true true SjrRating 11289558 /api/sjrrating/11289558 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 true 1604 true D1 DIRECT true true /api/publication/32651528 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csípő T. (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology; <span title="University of Debrecen">UD</span>/<span title="Orvostudományi Doktori Tanács">ODT</span>/Kálmán Laki Doctoral School</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038697"><a href="/gui2/?type=authors&mode=browse&sel=10038697" target="_blank">Czikora Á. (<span class="authorship-author-name">Czikora Ágnes</span> <span class="authorAux-mtmt"> Onkologia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044572"><a href="/gui2/?type=authors&mode=browse&sel=10044572" target="_blank">Fülöp G.Á. (<span class="authorship-author-name">Fülöp Gábor Áron</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology; <span title="University of Debrecen">UD</span>/<span title="Orvostudományi Doktori Tanács">ODT</span>/Kálmán Laki Doctoral School</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067183"><a href="/gui2/?type=authors&mode=browse&sel=10067183" target="_blank">Gulyás H. (<span class="authorship-author-name">Gulyás Hajnalka</span> <span class="authorAux-mtmt"> kísérletes orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Debrecen">UD</span>/<span title="Orvostudományi Doktori Tanács">ODT</span>/Doctoral School of Pharmacy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038698"><a href="/gui2/?type=authors&mode=browse&sel=10038698" target="_blank">Rutkai I. (<span class="authorship-author-name">Rutkai Ibolya</span> <span class="authorAux-mtmt"> szív és érrendszer</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038727"><a href="/gui2/?type=authors&mode=browse&sel=10038727" target="_blank">Tóth E.P. (<span class="authorship-author-name">Pásztorné Tóth Enikő</span> <span class="authorAux-mtmt"> szív és érrendszer</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012492"><a href="/gui2/?type=authors&mode=browse&sel=10012492" target="_blank">Pórszász R. (<span class="authorship-author-name">Pórszász Róbert</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szalai A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017552"><a href="/gui2/?type=authors&mode=browse&sel=10017552" target="_blank">Bölcskei K. (<span class="authorship-author-name">Bölcskei Kata</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001426"><a href="/gui2/?type=authors&mode=browse&sel=10001426" target="_blank">Helyes Z. (<span class="authorship-author-name">Helyes Zsuzsanna</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012367"><a href="/gui2/?type=authors&mode=browse&sel=10012367" target="_blank">Pintér E. (<span class="authorship-author-name">Pintér Erika</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Pharmacology and Pharmacotherapy; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Pharmacology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000066"><a href="/gui2/?type=authors&mode=browse&sel=10000066" target="_blank">Papp Z. (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szív élettan</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvári Z. (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003186"><a href="/gui2/?type=authors&mode=browse&sel=10003186" target="_blank">Tóth A. ✉ (<span class="authorship-author-name">Tóth Attila</span> <span class="authorAux-mtmt"> Szív és érrendszer, fájdalomkutatás</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Institute of Cardiology">KardI</span>/Department of Cardiology; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32651528" target="_blank">A Central Role for TRPM4 in Ca2+-Signal Amplification and Vasoconstriction</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">3</span> <span class="page"> Paper 1465. 13 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms23031465" target="_blank" href="https://doi.org/10.3390/ijms23031465"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000756238000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000756238000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85123579850" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85123579850"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35163382" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35163382&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 12 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 13 | Number of citations in Scopus:&nbsp;14 | WoS/Scopus assigned:&nbsp;14 | Number of citations with DOI:&nbsp;14 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32651528</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (K116940) Funder: HSRF, Kezelés-specifikus diagnosztikus módszerek fejlesztése a személyre szabott kardiovaszkuláris terá...(K 132623), (TKP2020-NKA-04), (TKP2020-IKA-04), (2020-4.1.1-TKP2020) Funder: NRDIO, (GINOP-2.3.2-15-2016-00050) </div> <div class="lastModified">Last Modified: 2022.10.13. 08:48 Róbert Milánkovics (PTE ÁOK admin 4) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:10 Gusztáv Ladányi (MTMT API user, admin) Zsófia Orbán (MTMT ellenőrzés, admin) </div> </div></div>