(National Tumor Biology Laboratory, NLP-17) Funder: The Hungarian National Laboratories
Excellence program
Pheochromocytomas and paragangliomas are the most heritable endocrine tumors. In addition
to the inherited mutation other driver mutations have also been identified in tumor
tissues. All these genetic alterations are clustered in distinct groups which determine
the pathomechanisms. Most of these tumors are benign and their surgical removal will
resolve patient management. However, 5-15% of them are malignant and therapeutical
possibilities for them are limited. This review provides a brief insight about the
tumorigenesis associated with pheochromocytomas/paragangliomas in order to present
them as potential therapeutical targets.
