Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia

Ihnatko, Martin; Truchla, Ivana; Ihnatkova, Ludmila; Prohaszka, Zoltan [Prohászka, Zoltán (Immunológia), szerző] Belgyógyászati és Hematológiai Klinika (SE / AOK / K); Lazurova, Ivica ✉

Angol nyelvű Szakcikk (Folyóiratcikk) Tudományos
Megjelent: FRONTIERS IN MEDICINE 2296-858X 8 Paper: 789972 , 5 p. 2022
  • SJR Scopus - Medicine (miscellaneous): Q1
Azonosítók
Támogatások:
  • (2020-1.1.6-JOVO-2021-00013)
COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is a rare complication of adenoviral vector (ChAdOx1 nCoV-19) vaccine administration. It is presented as thrombocytopenia and thrombotic manifestations in various sites, especially in cerebral veins. Pulmonary emboli have been reported rarely. We present a case of a young male patient who developed severe thrombocytopenia and pulmonary embolism 12 days after the first dose of the vaccine. Severe thrombocytopenia, skin hematomas, and segmental pulmonary emboli were detected. Anti-platelet factor 4 (aPF-4) antibody was highly positive supporting the diagnosis of VITT. Prompt treatment with fondaparinux, intravenous immunoglobulin, and prednisone led to a marked improvement of clinical condition and thrombocytes count. We report the first known case of VITT in Slovakia.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2025-04-17 05:20