Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested
as Pulmonary Embolism and Hemorrhagia. A First Reported Case From Slovakia
COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is a rare complication
of adenoviral vector (ChAdOx1 nCoV-19) vaccine administration. It is presented as
thrombocytopenia and thrombotic manifestations in various sites, especially in cerebral
veins. Pulmonary emboli have been reported rarely. We present a case of a young male
patient who developed severe thrombocytopenia and pulmonary embolism 12 days after
the first dose of the vaccine. Severe thrombocytopenia, skin hematomas, and segmental
pulmonary emboli were detected. Anti-platelet factor 4 (aPF-4) antibody was highly
positive supporting the diagnosis of VITT. Prompt treatment with fondaparinux, intravenous
immunoglobulin, and prednisone led to a marked improvement of clinical condition and
thrombocytes count. We report the first known case of VITT in Slovakia.