https://m2.mtmt.hu/ hun 2026-09-22 15:36 JournalArticle 32629331 APPROVED true 0 false 2026-09-03T13:16:27.447+0000 2026-08-10T13:57:50.041+0000 2022-01-28T07:46:30.586+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-08-10T13:00:18.268+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gunawardene, Melanie A. Pulsed-field ablation combined with ultrahigh-density mapping in patients undergoing catheter ablation for atrial fibrillation: Practical and electrophysiological considerations true true /api/journal/2319 REVIEWED true false 2319 false 2319 true 1045-3873 1540-8167 Journal FOREIGN 33 3 345 356 345 12 2022 Background Pulsed-field ablation (PFA) yields a novel ablation technology for atrial fibrillation (AF). PFA lesions promise to be highly durable, however clinical data on lesion characteristics are still limited. Objective This study sought to investigate PFA lesion creation with ultrahigh-density (UHDx) mapping. Methods Consecutive AF patients underwent PFA-based pulmonary vein isolation (PVI) using a multispline catheter (Farwave, Farapulse Inc.). Additional ablation, including left atrial posterior wall isolation (LAPWI) and mitral isthmus ablation (MI) were performed in a subset of persistent AF patients. The extent of PFA-lesions and decrease of LA-voltage were assessed with pre- and post PFA UHDx-mapping (Orion (TM) catheter and Rhythmia (TM) 3D-mapping system, Boston Scientific). Results In 20 patients, acute PVI was achieved in 80/80 PVs, LAPW isolation in 9/9 patients, MI ablation in 2/2 (procedure time: 123 +/- 21.6 min, fluoroscopy time: 19.2 +/- 5.5 min). UHDx-mapping subsequent to PVI revealed early PV-reconnection in five case (5/80, 6.25%). Gaps were located at the anterior-superior PV ostia and were successfully targeted with additional PFA. Repeat UHDx mapping after PFA revealed a significant decrease of voltage along the PV ostia (1.67 +/- 1.36 mV vs. 0.053 +/- 0.038 mV, p < .0001) with almost no complex electrogram-fractionation at the lesion border zones. PFA-catheter visualization within the mapping system was feasible in 17/19 (84.9%) patients and adequate in 92.9% of ablation sites. Conclusion For the first time illustrated by UHDx mapping, PFA creates wide antral circumferential lesions and homogenous LAPW isolation with depression of tissue voltage to a minimum. Although with a low incidence, early PV reconnection can still occur also in the setting of PFA. true true 2022 true true true false false false NONE 2026-09-03 false 72 0 72 65 2 72 72 66 71 72 72 65 65 65 7 0 72 65 72 65 0 1 1 Folyóiratcikk Journal Article 24 70 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 3 2 3 2 2023 0 18 17 18 17 2024 0 24 22 24 22 2025 0 23 20 23 20 2026 0 4 4 4 4 Q1 false false false false 2022-04-26T09:53:43.186+0000 Asklepios Campus Hamburg (SE / AOK); Semmelweis Egyetem 4 3 2 13 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 100330739 /api/authorship/100330739 1 0.077 true false true Author 10082263 /api/author/10082263 Gunawardene Melanie A true true Gunawardene Melanie A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330740 /api/authorship/100330740 2 0.07692308 false false false Schaeffer Benjamin N. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330741 /api/authorship/100330741 3 0.07692308 false false false Jularic Mario true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330742 /api/authorship/100330742 4 0.07692308 false false false Eickholt Christian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330743 /api/authorship/100330743 5 0.07692308 false false false Maurer Tilman true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330744 /api/authorship/100330744 6 0.07692308 false false false Akbulak Ruken O. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330745 /api/authorship/100330745 7 0.07692308 false false false Flindt Max true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330746 /api/authorship/100330746 8 0.07692308 false false false Anwar Omar true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330747 /api/authorship/100330747 9 0.077 false false false Author 10095421 /api/author/10095421 Pape Ulrich-Frank true true Pape Ulrich F. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330748 /api/authorship/100330748 10 0.07692308 false false false Maasberg Sebastian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330749 /api/authorship/100330749 11 0.07692308 false false false Author 10082648 /api/author/10082648 Gessler Nele true true Gessler Nele true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330750 /api/authorship/100330750 12 0.07692308 false false false Hartmann Jens true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 100330751 /api/authorship/100330751 13 0.077 false true false Author 10084394 /api/author/10084394 Willems Stephan true true Willems Stephan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20490982 /api/publicationidentifier/20490982 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true 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PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34978360 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34978360&dopt=Abstract false true Keyword 1101336 /api/keyword/1101336 true 1101336 true Keyword 1176346 /api/keyword/1176346 true 1176346 true Keyword 1176346 /api/keyword/1176346 true 1176346 true Keyword 2407845 /api/keyword/2407845 true true Keyword 2572096 /api/keyword/2572096 true true SjrRating 11311788 /api/sjrrating/11311788 81 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q1 DIRECT true true /api/publication/32629331 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10082263"><a href="/gui2/?type=authors&mode=browse&sel=10082263" target="_blank">Gunawardene Melanie A. ✉ (<span class="authorship-author-name">Gunawardene Melanie A</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Semmelweis Egyetem; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/Asklepios Campus Hamburg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schaeffer Benjamin N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jularic Mario </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Eickholt Christian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maurer Tilman </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Akbulak Ruken O. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Flindt Max </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anwar Omar </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095421"><a href="/gui2/?type=authors&mode=browse&sel=10095421" target="_blank">Pape Ulrich F. (<span class="authorship-author-name">Pape Ulrich-Frank</span> <span class="authorAux-mtmt"> </span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maasberg Sebastian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082648"><a href="/gui2/?type=authors&mode=browse&sel=10082648" target="_blank">Gessler Nele (<span class="authorship-author-name">Gessler Nele</span> <span class="authorAux-mtmt"> Medicine</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hartmann Jens </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084394"><a href="/gui2/?type=authors&mode=browse&sel=10084394" target="_blank">Willems Stephan (<span class="authorship-author-name">Willems Stephan</span> <span class="authorAux-mtmt"> Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/Asklepios Campus Hamburg</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32629331" target="_blank">Pulsed-field ablation combined with ultrahigh-density mapping in patients undergoing catheter ablation for atrial fibrillation: Practical and electrophysiological considerations</a></div> <div> <span class="journal-title">JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1045-3873">1045-3873</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1540-8167">1540-8167</a>)</span>: <span class="journal-volume">33</span> <span class="journal-issue">3</span> <span class="page"> pp 345-356 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/jce.15349" target="_blank" href="https://doi.org/10.1111/jce.15349"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000740453300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000740453300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85122621271" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85122621271"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34978360" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34978360&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 72</span> | Független: 65 | Függő: 7 | Nem jelölt: 0 | WoS jelölt: 66 | Scopus jelölt:&nbsp;71 | WoS/Scopus jelölt:&nbsp;72 | DOI jelölt:&nbsp;72 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32629331&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32629331</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.08.10. 15:57 Koop Malte (SE_AOK_Asklepios_Admin, admin) </div> </div></div>