https://m2.mtmt.hu/ hun 2026-05-01 14:25 JournalArticle 32611202 VALIDATED true 0 false 2026-04-29T09:44:20.852+0000 2026-02-11T13:35:22.133+0000 2022-01-23T17:16:53.615+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author Ferdinandy Péter (Farmakológia, molekuláris medicina) true 10010125 2026-04-08T13:17:15.790+0000 2026-04-08T13:17:15.790+0000 2024-09-17T08:16:43.949+0000 true 10073918 Kovács Marcell /api/admin/10073918 Admin Kovács Marcell (MTMT Közp., admin) true Admin 10063514 /api/admin/10063514 Mikola Katalin (MTMT 3, admin) Mikola Katalin true 10063514 true 2026-01-21T13:12:53.998+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Hegyesi, Hargita true true /api/journal/11507 REVIEWED CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X 1420-9071 true false 11507 false 11507 true 1420-682X 1420-9071 Journal FOREIGN 79 2 84 84 15 2022 The release of extracellular vesicles (EVs) is increased under cellular stress and cardiomyocyte damaging conditions. However, whether the cardiomyocyte-derived EVs eventually reach the systemic circulation and whether their number in the bloodstream reflects cardiac injury, remains unknown. Wild type C57B/6 and conditional transgenic mice expressing green fluorescent protein (GFP) by cardiomyocytes were studied in lipopolysaccharide (LPS)-induced systemic inflammatory response syndrome (SIRS). EVs were separated both from platelet-free plasma and from the conditioned medium of isolated cardiomyocytes of the left ventricular wall. Size distribution and concentration of the released particles were determined by Nanoparticle Tracking Analysis. The presence of GFP + cardiomyocyte-derived circulating EVs was monitored by flow cytometry and cardiac function was assessed by echocardiography. In LPS-treated mice, systemic inflammation and the consequent cardiomyopathy were verified by elevated plasma levels of TNF alpha, GDF-15, and cardiac troponin I, and by a decrease in the ejection fraction. Furthermore, we demonstrated elevated levels of circulating small- and medium-sized EVs in the LPS-injected mice. Importantly, we detected GFP(+) cardiomyocyte-derived EVs in the circulation of control mice, and the number of these circulating GFP(+) vesicles increased significantly upon intraperitoneal LPS administration (P = 0.029). The cardiomyocyte-derived GFP(+) EVs were also positive for intravesicular troponin I (cTnI) and muscle-associated glycogen phosphorylase (PYGM). This is the first direct demonstration that cardiomyocyte-derived EVs are present in the circulation and that the increased number of cardiac-derived EVs in the blood reflects cardiac injury in LPS-induced systemic inflammation (SIRS). Funding 2008386 /api/funding/2008386 (NVKP_16-1-20160017) Támogató: Hungarian National Research, Development and Innovation Office false true Funding 2008387 /api/funding/2008387 (OTKA K120237) false true Funding 2008388 /api/funding/2008388 (VEKOP-2.3.2-16-2016-00000) false true Funding 2008389 /api/funding/2008389 (VEKOP-2.3.3-15-2017-00016) false true Funding 2008390 /api/funding/2008390 (TKP2020-NKA-26) false true Funding 2008391 /api/funding/2008391 (H2020-MSCA-ITN-2017-722148 TRAIN EV) false true Funding 2008392 /api/funding/2008392 (739593) Támogató: Horizon 2020 false true Funding 2008393 /api/funding/2008393 (VEKOP-2.3.3-15-2016-00006) false true true true 2022 true true true false true false GOLD 2026-04-29 true https://doi.org/10.1007/s00018-021-04125-w 31 0 31 22 9 31 31 31 30 31 31 22 22 22 9 0 31 22 31 22 0 7 7 Folyóiratcikk Journal Article 24 31 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 12 8 12 8 2024 0 11 8 11 8 2025 0 6 5 6 5 2026 0 2 1 2 1 D1 false 10015589,10012417 false false false 2022-01-31T12:54:03.216+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HCEMM-SE Extracelluláris Vezikula Kutatócsoport (SE / AOK / I / GSII); Kísérleti Orvostudományi Kutatóintézet; MTA-SE Immun-proteogenomikai Extracelluláris Ve... (SE / AOK / I / GSII); Országos Onkológiai Intézet; Szerves Kémiai Intézet (MTA TTK) 12 58 7 14 0 true 10063514 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 100098740 /api/authorship/100098740 Hegyesi, Hargita ✉ [Hegyesi, Hargita (Molekuláris onkol...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 1 0.071 true false true Author 10012417 /api/author/10012417 Hegyesi Hargita (Molekuláris onkológia) Hegyesi Hargita true 10012417 true Hegyesi Hargita true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098741 /api/authorship/100098741 Pallinger, Éva [Pállinger, Éva (Immunológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 2 0.071 false false false Author 10015589 /api/author/10015589 Pállinger Éva (Immunológia) Pállinger Éva true 10015589 true Pallinger Éva true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098742 /api/authorship/100098742 Mecsei, Szabina 3 0.071428575 false false false Mecsei Szabina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098743 /api/authorship/100098743 Hornyák, Balázs 4 0.071428575 false false false Hornyák Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098744 /api/authorship/100098744 Kovácsházi, Csenger [Kovácsházi, Csenger (Gyógyszertudomány), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 5 0.071 false false false Author 10069239 /api/author/10069239 Kovácsházi Csenger (Gyógyszertudomány) Kovácsházi Csenger true true Kovácsházi Csenger true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098745 /api/authorship/100098745 Brenner, Gábor B. [Brenner, Gábor (Kardiovaszkuláris...), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 6 0.071 false false false Author 10052112 /api/author/10052112 Brenner Gábor (Kardiovaszkuláris farmakológia) Brenner Gábor true 10052112 true Brenner Gábor B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098746 /api/authorship/100098746 Giricz, Zoltán [Giricz, Zoltán (Biokémia, Farmako...), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 7 0.071 false false false Author 10026898 /api/author/10026898 Giricz Zoltán (Biokémia, Farmakológia) Giricz Zoltán true 10026898 true Giricz Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098747 /api/authorship/100098747 Pálóczi, Krisztina [Pálóczi, Krisztina (immunológia, gene...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 8 0.071 false false false Author 10024466 /api/author/10024466 Pálóczi Krisztina (immunológia, genetika) Pálóczi Krisztina true 10024466 true Pálóczi Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098748 /api/authorship/100098748 Kittel, Ágnes [Kittel, Ágnes (Sejtbiológia), szerző] Kísérleti Orvostudományi Kutatóintézet 9 0.071 false false false Author 10009113 /api/author/10009113 Kittel Ágnes (Sejtbiológia) Kittel Ágnes true 10009113 true Kittel Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098749 /api/authorship/100098749 Tóvári, József [Tóvári, József (Daganatbiológia, ...), szerző] Országos Onkológiai Intézet 10 0.071428575 false false false Author 10009941 /api/author/10009941 Tóvári József (Daganatbiológia, áttétképzés) Tóvári József true 10009941 true Tóvári József true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098750 /api/authorship/100098750 Turiak, Lilla [Turiák, Lilla (tömegspektrometri...), szerző] Szerves Kémiai Intézet (MTA TTK) 11 0.071428575 false false false Author 10024570 /api/author/10024570 Turiák Lilla (tömegspektrometria, proteomika) Turiák Lilla true 10024570 true Turiak Lilla true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098751 /api/authorship/100098751 Khamari, Delaram [Khamari, Delaram (Extracellular ves...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 12 0.071 false false false Author 10071730 /api/author/10071730 Khamari Delaram (Extracellular vesicles) Khamari Delaram true true Khamari Delaram true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098752 /api/authorship/100098752 Ferdinandy, Péter [Ferdinandy, Péter (Farmakológia, mol...), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 13 0.071 false false false Author 10010125 /api/author/10010125 Ferdinandy Péter (Farmakológia, molekuláris medicina) Ferdinandy Péter true 10010125 true Ferdinandy Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 100098753 /api/authorship/100098753 Buzás, Edit I. 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(2022) CELLULAR AND MOLECULAR LIFE SCIENCES 1420-682X 1420-9071 79 2<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10012417"><a href="/gui2/?type=authors&mode=browse&sel=10012417" target="_blank">Hegyesi Hargita ✉ (<span class="authorship-author-name">Hegyesi Hargita</span> <span class="authorAux-mtmt"> Molekuláris onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015589"><a href="/gui2/?type=authors&mode=browse&sel=10015589" target="_blank">Pallinger Éva (<span class="authorship-author-name">Pállinger Éva</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mecsei Szabina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hornyák Balázs </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069239"><a href="/gui2/?type=authors&mode=browse&sel=10069239" target="_blank">Kovácsházi Csenger (<span class="authorship-author-name">Kovácsházi Csenger</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052112"><a href="/gui2/?type=authors&mode=browse&sel=10052112" target="_blank">Brenner Gábor B. (<span class="authorship-author-name">Brenner Gábor</span> <span class="authorAux-mtmt"> Kardiovaszkuláris farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026898"><a href="/gui2/?type=authors&mode=browse&sel=10026898" target="_blank">Giricz Zoltán (<span class="authorship-author-name">Giricz Zoltán</span> <span class="authorAux-mtmt"> Biokémia, Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024466"><a href="/gui2/?type=authors&mode=browse&sel=10024466" target="_blank">Pálóczi Krisztina (<span class="authorship-author-name">Pálóczi Krisztina</span> <span class="authorAux-mtmt"> immunológia, genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009113"><a href="/gui2/?type=authors&mode=browse&sel=10009113" target="_blank">Kittel Ágnes (<span class="authorship-author-name">Kittel Ágnes</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil">Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009941"><a href="/gui2/?type=authors&mode=browse&sel=10009941" target="_blank">Tóvári József (<span class="authorship-author-name">Tóvári József</span> <span class="authorAux-mtmt"> Daganatbiológia, áttétképzés</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024570"><a href="/gui2/?type=authors&mode=browse&sel=10024570" target="_blank">Turiak Lilla (<span class="authorship-author-name">Turiák Lilla</span> <span class="authorAux-mtmt"> tömegspektrometria, proteomika</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Szerves Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071730"><a href="/gui2/?type=authors&mode=browse&sel=10071730" target="_blank">Khamari Delaram (<span class="authorship-author-name">Khamari Delaram</span> <span class="authorAux-mtmt"> Extracellular vesicles</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015596"><a href="/gui2/?type=authors&mode=browse&sel=10015596" target="_blank">Buzás Edit I. (<span class="authorship-author-name">Buzás Edit Irén</span> <span class="authorAux-mtmt"> Immunbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/MTA-SE Immun-proteogenomikai Extracelluláris Vezikula Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/HCEMM-SE Extracelluláris Vezikula Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32611202" target="_blank">Circulating cardiomyocyte-derived extracellular vesicles reflect cardiac injury during systemic inflammatory response syndrome in mice</a></div> <div> <span class="journal-title">CELLULAR AND MOLECULAR LIFE SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-682X">1420-682X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-9071">1420-9071</a>)</span>: <span class="journal-volume">79</span> <span class="journal-issue">2</span> <span class="page"> Paper 84. 15 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s00018-021-04125-w" target="_blank" href="https://doi.org/10.1007/s00018-021-04125-w"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000745011300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000745011300001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="160664" target="_blank" href="http://real.mtak.hu/160664"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85123288587" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85123288587"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35059851" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35059851&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 31</span> | Független: 22 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 31 | Scopus jelölt:&nbsp;30 | WoS/Scopus jelölt:&nbsp;31 | DOI jelölt:&nbsp;31 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32611202&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32611202</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NVKP_16-1-20160017) Támogató: OTKA, (OTKA K120237), (VEKOP-2.3.2-16-2016-00000), (VEKOP-2.3.3.-15-2017-00016), (TKP2020-NKA-26), (H2020-MSCA-ITN-2017-722148 TRAIN EV), HCEMM(739593) Támogató: Horizon 2020, (VEKOP-2.3.3-15-2016-00006) </div> <div class="lastModified">Utolsó módosítás: 2026.02.11. 14:35 Balázs András (MTMT Központ, admin) </div> <div class="lockedBy">Központi kezelésű 2026.01.21. 14:12 Mikola Katalin (MTMT 3, admin) </div> </div></div>