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Pharmacology and Toxicology Graduate Group, University of California, Davis, Davis, CA, United States
Department of Chemistry, University of California, Davis, Davis, CA, United States
Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, United States
Center for Neuroscience, University of California, Davis, Davis, CA, United States
Cited By :1
Export Date: 18 January 2022
CODEN: JONRA
Correspondence Address: Olson, D.E.; Department of Chemistry, United States; email: deolson@ucdavis.edu
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Psychedelic-inspired approaches for treating neurodegenerative disorders
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Psychedelics are increasingly being recognized for their potential to treat a wide range of brain disorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder. Their broad therapeutic potential might result from an ability to rescue cortical atrophy common to many neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor gene expression, activating neuronal growth and survival mechanisms, and modulating the immune system. While the therapeutic potential of psychedelics has not yet been extended to neurodegenerative disorders, we provide evidence suggesting that approaches based on psychedelic science might prove useful for treating these diseases. The primary target of psychedelics, the 5-HT2A receptor, plays key roles in cortical neuron health and is dysregulated in Alzheimer's disease. Moreover, evidence suggests that psychedelics and related compounds could prove useful for treating the behavioral and psychological symptoms of dementia (BPSD). While more research is needed to probe the effects of psychedelics in models of neurodegenerative diseases, the robust effects of these compounds on structural and functional neuroplasticity and inflammation clearly warrant further investigation. © 2021 International Society for Neurochemistry
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Saeger, H.N. </span> <span class="author-type"> </span> ; <span class="author-name" > Olson, D.E. ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;32599853" mtid="32599853" target="_blank">Psychedelic-inspired approaches for treating neurodegenerative disorders</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF NEUROCHEMISTRY</span> <span class="journal-volume">162</span> : <span class="journal-issue">1</span> <span class="page"> pp. 109-127. , 19 p. </span> <span class="year">(2022)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/jnc.15544" target="_blank" href="https://doi.org/10.1111/jnc.15544"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000726335900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000726335900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85120478558" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85120478558"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34816433" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34816433&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:32599853 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Összefoglaló cikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Saeger H.N.
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<span class="author-name" >Olson D.E. ✉
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;32599853" target="_blank">Psychedelic-inspired approaches for treating neurodegenerative disorders</a></div> <div> <span class="journal-title">JOURNAL OF NEUROCHEMISTRY</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0022-3042">0022-3042</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-4159">1471-4159</a>)</span>:
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<div class="lastModified">Utolsó módosítás: 2022.11.14. 10:51 Szuper Admin (admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Pharmacology and Toxicology Graduate Group, University of California, Davis, Davis, CA, United States
Department of Chemistry, University of California, Davis, Davis, CA, United States
Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, United States
Center f...</pre>
</div></div>