{ "labelLang" : "hun", "responseDate" : "2024-03-29 05:50", "content" : { "otype" : "JournalArticle", "mtid" : 3258925, "status" : "APPROVED", "published" : true, "comment" : "Ti:Diagnostic and therapeutical significance of macro-TSH in patients with Hashimoto’s thyroiditis\nWoS:hiba:000408651100004 2020-08-28 06:10 cím nem egyezik", "unhandledTickets" : 0, "oldTimestamp" : "2018-07-02T22:22:15.000+0000", "deleted" : false, "oldId" : 3258925, "lastRefresh" : "2024-02-18T22:25:59.185+0000", "lastModified" : "2021-06-02T13:43:49.980+0000", "created" : "2017-08-30T11:51:18.000+0000", "creator" : { "otype" : "Author", "mtid" : 10009274, "link" : "/api/author/10009274", "label" : "Rácz Károly (belgyógyászat, endokrinologia)", "familyName" : "Rácz", "givenName" : "Károly", "duplumRole" : "DUPLUM", "published" : true, "oldId" : 10009274, "snippet" : true }, "lastDuplumOK" : "2021-03-05T11:46:29.333+0000", "lastDuplumSearch" : "2021-03-05T11:46:29.333+0000", "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10001, "link" : "/api/language/10001", "label" : "Magyar", "name" : "Magyar", "nameEng" : "Hungarian", "published" : true, "oldId" : 1, "snippet" : true } ], "firstAuthor" : "Balazs, C", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 9281926, "link" : "/api/authorship/9281926", "label" : "Balazs, C", "listPosition" : 1, "share" : 0.5, "first" : true, "last" : false, "familyName" : "Balazs", "givenName" : "C", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 26731701, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 9281927, "link" : "/api/authorship/9281927", "label" : "Racz, K [Rácz, Károly (belgyógyászat, en...), szerző] II. Sz. Belgyógyászati Klinika (SE / AOK / K)", "listPosition" : 2, "share" : 0.5, "first" : false, "last" : true, "author" : { "otype" : "Author", "mtid" : 10009274, "link" : "/api/author/10009274", "label" : "Rácz Károly (belgyógyászat, endokrinologia)", "familyName" : "Rácz", "givenName" : "Károly", "duplumRole" : "DUPLUM", "published" : true, "oldId" : 10009274, "snippet" : true }, "familyName" : "Racz", "givenName" : "K", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 26731700, "snippet" : true } ], "title" : "A makro-TSH diagnosztikus és terápiás jelentősége Hashimoto-thyreoiditises betegekben", "subTitle" : "Diagnostic and therapeutical significance of macro-TSH in patients with Hashimoto’s thyroiditis", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 1222266, "link" : "/api/publicationidentifier/1222266", "label" : "DOI: 10.1556/650.2017.30831", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaType" : "GOLD", "oaFree" : true, "validState" : "IDENTICAL", "idValue" : "10.1556/650.2017.30831", "realUrl" : "https://doi.org/10.1556/650.2017.30831", "published" : false, "oldId" : 1625549, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1222268, "link" : "/api/publicationidentifier/1222268", "label" : "SE Repozitórium: 5113", "source" : { "otype" : "SwordSource", "mtid" : 84, "link" : "/api/publicationsource/84", "label" : "SE Repozitórium", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "SE Repozitórium", "nameEng" : "SE Repozitórium", "linkPattern" : "https://repo.lib.semmelweis.hu/handle/123456789/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 84, "snippet" : true }, "oaType" : "GREEN", "oaFree" : true, "validState" : "IDENTICAL", "idValue" : "5113", "realUrl" : "https://repo.lib.semmelweis.hu/handle/123456789/5113", "published" : false, "oldId" : 1739375, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 13086159, "link" : "/api/publicationidentifier/13086159", "label" : "WoS: 000408651100004", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000408651100004", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000408651100004", "published" : false, "oldId" : 15800917, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1222267, "link" : "/api/publicationidentifier/1222267", "label" : "PubMed: 28823206", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "28823206", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28823206&dopt=Abstract", "published" : false, "oldId" : 1625550, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 1035675, "link" : "/api/journal/1035675", "label" : "ORVOSI HETILAP 0030-6002 1788-6120", "pIssn" : "0030-6002", "eIssn" : "1788-6120", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "HUNGARIAN", "hungarian" : true, "published" : true, "oldId" : 1035675, "snippet" : true }, "volume" : "158", "issue" : "34", "firstPage" : "1346", "lastPage" : "1350", "firstPageOrInternalIdForSort" : "1346", "pageLength" : 5, "publishedYear" : 2017, "abstractText" : "INTRODUCTION: Structure, importance and incidence and clinical role of macro-TSH not clarified in thyroid diseases. AIM: This study was undertaken to determine the incidence and biological role of macro-TSH in patients with Hashimoto's thyroiditis. METHOD: Blood samples taken from patients with Hashimoto's thyroiditis were screened for the presence of macro-TSH with the polyethylene glycol method and confirmed with protein G agarose absorption test and gel filtration chromatography. Stimulatory capacity of macro-TSH was measured by CHO cells bio-assay. Patients were treated with L-thyroxine (mean 66.5 microg/day) and half of them with selenium (mean 60 microg/day), respectively. RESULTS: 880 patients (728 female, aged 44.8 yr) with Hashimoto's thyroiditis was involved in the study. Macro-TSH was found in the serum of 41 patients (4.6%), the mean TSH 185.4 +/- 35 IU/l was before PEG precipitations and after 5.55 +/- 1.8 IU/l. Titre of anti-TPO proved to be 445 +/- 51 IU/l and gradulally decreased to 212 +/- 51 IU/l after one year therapy. Both the precipitation, protein G absorption and gel chromatography supported the presence of anti-TSH antibody in the macro-TSH complex. Stimulatory capacity of macro-TSH on CHO bio-assay was not proved. The macro-TSH was detected in the selenium not treated group for 18 +/- 3.2 months, selenium-treated for 12 +/- 1.9 months. CONCLUSION: It is concluded that anti-human TSH autoantibodies are a major components of macro-TSH and may cause diagnostic and therapeutical difficulties. The PEG precipitation is a suitable screening method for detection of macro-TSH. Selenium is able to decrease of anti-TPO antibodies and macro-TSH, respectively. When the TSH level is greater than 40.0 IU/l, without the signs of hypothyroidism, the presence of macro-TSH is to be considered. Orv Hetil. 2017; 158(34): 1346-1350.", "digital" : true, "printed" : true, "sourceYear" : 2017, "packet" : "(Rácz Károly (belgyógyászat, endokrin...); 2017.08.30. 13:49:08)", "foreignEdition" : false, "foreignLanguage" : false, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-02-18", "oaFree" : true, "oaLink" : "https://doi.org/10.1556/650.2017.30831", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "nationalOriginCitationCount" : 0, "foreignEditionCitationCount" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "wosScopusCitationCount" : 0, "wosScopusCitationCountWoOther" : 0, "wosScopusIndependentCitationCount" : 0, "wosScopusIndependentCitationCountWoOther" : 0, "independentCitationCount" : 0, "selfCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "citingPubCountWoOther" : 0, "independentCitingPubCountWoOther" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "MtaRating", "mtid" : 10487092, "link" : "/api/mtarating/10487092", "label" : "II. Pszichológiai Tudományos Bizottság:A ORVOSI HETILAP 0030-6002 1788-6120", "ratingType" : { "otype" : "RatingType", "mtid" : 10026, "link" : "/api/ratingtype/10026", "label" : "II. Pszichológiai Tudományos Bizottság", "code" : "PsziTB", "institute" : { "otype" : "Institute", "mtid" : 14108, "link" : "/api/institute/14108", "label" : "Pszichológiai Tudományos Bizottság II. FTO PsziTB [1901-]", "childrenCount" : 0, "allowInstForum" : false, "allowOnlineRegistration" : true, "name" : "Pszichológiai Tudományos Bizottság", "nameEng" : "Pszichológiai Tudományos Bizottság", "published" : true, "oldId" : 14108, "snippet" : true }, "published" : true, "snippet" : true }, "val" : "A", "published" : true, "snippet" : true }, { "otype" : "MtaRating", "mtid" : 11507998, "link" : "/api/mtarating/11507998", "label" : "IX. Demográfiai Osztályközi Állandó Bizottság:A hazai ORVOSI HETILAP 0030-6002 1788-6120", "ratingType" : { "otype" : "RatingType", "mtid" : 10011, "link" : "/api/ratingtype/10011", "label" : "IX. Demográfiai Osztályközi Állandó Bizottság", "code" : "DEM", "institute" : { "otype" : "Institute", "mtid" : 19060, "link" : "/api/institute/19060", "label" : "Demográfiai Osztályközi Állandó Bizottság IXGJO DEM [1901-]", "childrenCount" : 0, "allowInstForum" : false, "allowOnlineRegistration" : true, "name" : "Demográfiai Osztályközi Állandó Bizottság", "nameEng" : "Demográfiai Osztályközi Állandó Bizottság", "published" : true, "oldId" : 19060, "snippet" : true }, "published" : true, "snippet" : true }, "val" : "A hazai", "published" : false, "snippet" : true }, { "otype" : "SjrRating", "mtid" : 10974067, "link" : "/api/sjrrating/10974067", "label" : "sjr:Q4 (2017) Scopus - Medicine (miscellaneous) ORVOSI HETILAP 0030-6002 1788-6120", "listPos" : 2123, "rankValue" : 1.0, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2701, "link" : "/api/classificationexternal/2701", "label" : "Scopus - Medicine (miscellaneous)", "published" : true, "oldId" : 2701, "snippet" : true }, "ranking" : "Q4", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q4", "mtaRatingsForSort" : "A", "hasCitationDuplums" : false, "userChangeableUntil" : "2018-05-23T13:15:38.000+0000", "publishDate" : "2017-08-30T11:53:53.000+0000", "directInstitutesForSort" : "II. Sz. Belgyógyászati Klinika (SE / AOK / K)", "ownerAuthorCount" : 1, "ownerInstituteCount" : 7, "directInstituteCount" : 1, "authorCount" : 2, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/3258925", "label" : "Balazs C et al. A makro-TSH diagnosztikus és terápiás jelentősége Hashimoto-thyreoiditises betegekben: Diagnostic and therapeutical significance of macro-TSH in patients with Hashimoto’s thyroiditis. (2017) ORVOSI HETILAP 0030-6002 1788-6120 158 34 1346-1350", "template" : "