https://m2.mtmt.hu/ eng 2026-10-23 18:49 JournalArticle 32586000 VALIDATED true Supplement: 1_ 0 false 2026-10-22T01:59:07.625+0000 2022-06-18T15:18:53.052+0000 2022-01-11T10:22:23.344+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-03-24T08:34:08.534+0000 2022-06-18T15:18:53.061+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Merkely, Gergo Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect on Cartilage Repair? A Systematic Review true true /api/journal/10020327 REVIEWED true false 10020327 false 10020327 true 1947-6035 1947-6043 Journal FOREIGN 13 1_SUPPL 326S 341S 326S 16 2021 Objectives The purpose of this study was to systematically review the available evidence regarding any plausible deleterious effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on chondrocytes, chondrocyte differentiation, and allograft or autograft incorporation after cartilage repair procedures. Design Three databases (PubMed, Science Direct, and Cochrane Library) were screened for eligible studies: investigating the effects of NSAIDs on chondrocytes, chondrogenic differentiation, or allograft/autograft incorporation. This evaluation included studies of any level of evidence, written in English, reporting clinical or preclinical results, published in peer review journals and dealing with our topic. All articles evaluating the effects of NSAIDs on either osteoarthritic (OA) chondrocyte samples or OA chondrocyte models were excluded. Moreover, articles about bone healing in which allograft or autograft incorporation was not investigated were also excluded. Methodologic quality assessment was performed for in vivo animal studies according to ARRIVE guidelines, and risk of bias of each included study was identified using the ROBINS-I tool. Results Eighteen studies were included in the review: 4 in vitro studies, 13 animal studies, and 1 human study. According to these studies NSAIDs have no detrimental effect on healthy mature chondrocytes; however, these drugs influence chondrocyte differentiation and graft incorporation and therefore may interfere with chondrogenesis and incorporation after transplantation of chondrocytes or osteochondral grafts. Conclusion The use of NSAIDs, systemic or local, after cartilage repair procedures should be avoided unless a substantial clinical benefit would otherwise be withheld from the patient. More human studies are needed to analyze the effect of NSAIDs on cartilage repair. 2022 true true true false false NONE 2026-10-22 false 15 0 15 13 1 15 15 14 8 15 15 13 13 13 2 0 15 13 15 13 0 0 0 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 2 1 2 1 2022 0 1 0 1 0 2023 0 1 1 1 1 2024 0 1 1 1 1 2025 0 7 7 7 7 2026 0 3 3 3 3 Q2 false false false false 2022-01-10T10:26:29.196+0000 Traumatológiai Tanszék (SE / AOK / K) 1 13 1 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 99954404 /api/authorship/99954404 1 0.25 true false true Author 10051885 /api/author/10051885 Merkely Gergő true 10051885 true Merkely Gergo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99954405 /api/authorship/99954405 2 0.25 false false false Chisari Emanuele true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99954406 /api/authorship/99954406 3 0.25 false false false Lola Rosso Claudia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99954407 /api/authorship/99954407 4 0.25 false true false Lattermann Christian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20390676 /api/publicationidentifier/20390676 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1177/1947603519855770 https://doi.org/10.1177/1947603519855770 false true PublicationIdentifier 20390677 /api/publicationidentifier/20390677 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000734513800027 https://www.webofscience.com/wos/woscc/full-record/000734513800027 false true PublicationIdentifier 20390749 /api/publicationidentifier/20390749 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85068027556 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85068027556 false true PublicationIdentifier 20390678 /api/publicationidentifier/20390678 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31216865 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31216865&dopt=Abstract false true Keyword 4209 /api/keyword/4209 true 4209 true Keyword 6472 /api/keyword/6472 true 6472 true Keyword 1006292 /api/keyword/1006292 true 1006292 true Keyword 1020087 /api/keyword/1020087 true 1020087 true Keyword 1022553 /api/keyword/1022553 true 1022553 true Keyword 1172070 /api/keyword/1172070 true 1172070 true Keyword 1500417 /api/keyword/1500417 true true Keyword 1500419 /api/keyword/1500419 true true Keyword 1513589 /api/keyword/1513589 true true Keyword 1526025 /api/keyword/1526025 true true Keyword 1677232 /api/keyword/1677232 true true Keyword 1953986 /api/keyword/1953986 true true SjrRating 11212773 /api/sjrrating/11212773 88 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2204 /api/classificationexternal/2204 true 2204 true Q2 DIRECT true true /api/publication/32586000 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051885"><a href="/gui2/?type=authors&mode=browse&sel=10051885" target="_blank">Merkely Gergo ✉ (<span class="authorship-author-name">Merkely Gergő</span> <span class="authorAux-mtmt"> ortopédia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Traumatology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chisari Emanuele </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lola Rosso Claudia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lattermann Christian </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32586000" target="_blank">Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect on Cartilage Repair? A Systematic Review</a></div> <div> <span class="journal-title">CARTILAGE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1947-6035">1947-6035</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1947-6043">1947-6043</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">1_SUPPL</span> <span class="page"> pp 326S-341S </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1177/1947603519855770" target="_blank" href="https://doi.org/10.1177/1947603519855770"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000734513800027" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000734513800027"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85068027556" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85068027556"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31216865" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31216865&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biomedical Engineering&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Physical Therapy, Sports Therapy and Rehabilitation&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 15</span> | Independent citation: 13 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;8 | WoS/Scopus assigned:&nbsp;15 | Number of citations with DOI:&nbsp;15 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32586000</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Last Modified: 2022.06.18. 17:18 Edit Csajbók (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Supplement: 1_</pre> </div></div>