https://m2.mtmt.hu/ hun 2026-10-24 20:45 JournalArticle 32585883 VALIDATED true 0 false 2026-10-22T01:59:13.208+0000 2025-03-21T09:34:57.137+0000 2022-01-11T10:00:13.375+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-03-17T20:48:24.228+0000 2022-07-13T09:41:03.706+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Keresztes, David Comparative proteome analysis identified CD44 as a possible serum marker for docetaxel resistance in castration-resistant prostate cancer true true /api/journal/10001233 REVIEWED true false 10001233 false 10001233 true 1582-1838 1582-4934 Journal FOREIGN 26 4 1332 1337 1332 6 2022 Baseline or acquired resistance to docetaxel (DOC) represents a significant risk for patients with metastatic prostate cancer (PC). In the last years, novel therapy regimens have been approved providing reasonable alternatives for DOC-resistant patients making prediction of DOC resistance of great clinical importance. We aimed to identify serum biomarkers, which are able to select patients who will not benefit from DOC treatment. DOC-resistant PC3-DR and DU145-DR sublines and their sensitive parental cell lines (DU145, PC3) were comparatively analyzed using liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS). Results were filtered using bioinformatics approaches to identify promising serum biomarkers. Serum levels of five proteins were determined in serum samples of 66 DOC-treated metastatic castration-resistant PC patients (mCRPC) using ELISA. Results were correlated with clinicopathological and survival data. CD44 was subjected to further functional cell culture analyses. We found at least 177 two-fold significantly overexpressed proteins in DOC-resistant cell lines. Our bioinformatics method suggested 11/177 proteins to be secreted into the serum. We determined serum levels of five (CD44, MET, GSN, IL13RA2 and LNPEP) proteins in serum samples of DOC-treated patients and found high CD44 serum levels to be independently associated with poor overall survival (p = 0.001). In accordance, silencing of CD44 in DU145-DR cells resulted in re-sensitization to DOC. In conclusion, high serum CD44 levels may help identify DOC-resistant patients and may thereby help optimize clinical decision-making regarding type and timing of therapy for mCRPC patients. In addition, our in vitro results imply the possible functional involvement of CD44 in DOC resistance. Funding 2012845 /api/funding/2012845 false true Funding 2012846 /api/funding/2012846 false true Funding 2012847 /api/funding/2012847 false true Funding 2012848 /api/funding/2012848 false true Funding 2012849 /api/funding/2012849 false true Funding 2012850 /api/funding/2012850 false true true 2022 true true true false true false GOLD 2026-10-22 true https://doi.org/10.1111/jcmm.17141 6 0 6 6 1 6 6 6 4 6 6 6 6 6 0 0 6 6 6 6 0 2 2 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 1 1 1 1 2025 0 3 3 3 3 Q2 false 10063755,10064212,10017538,10088809 false false false 2022-02-16T09:17:36.388+0000 Humángenetikai Tanszék (DE / ÁOK); Igazságügyi és Biztosítás-orvostani Intézet (SE / AOK / I); Országos Onkológiai Intézet; Urológiai Klinika (SE / AOK / K) 13 36 4 21 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 99953935 /api/authorship/99953935 1 0.048 true false false Author 10063755 /api/author/10063755 Keresztes Dávid true 10063755 true Keresztes David true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953936 /api/authorship/99953936 2 0.048 false false false Author 10064212 /api/author/10064212 Pásztor-Csizmarik Anita true 10064212 true Csizmarik Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953937 /api/authorship/99953937 3 0.048 false false false Author 10079981 /api/author/10079981 Habina-Nagy Nikolett true true Nagy Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953938 /api/authorship/99953938 4 0.048 false false false Author 10048779 /api/author/10048779 Módos Orsolya true 10048779 true Modos Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953939 /api/authorship/99953939 5 0.048 false false false Author 10073300 /api/author/10073300 Fazekas Tamás true true Fazekas Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953940 /api/authorship/99953940 6 0.04761905 false false false Bracht Thilo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953941 /api/authorship/99953941 7 0.04761905 false false false Sitek Barbara true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953942 /api/authorship/99953942 8 0.04761905 false false false Witzke Kathrin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953943 /api/authorship/99953943 9 0.04761905 false false false Puhr Martin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953944 /api/authorship/99953944 10 0.04761905 false false false Sevcenco Sabina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953945 /api/authorship/99953945 11 0.04761905 false false false Kramer Gero true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953946 /api/authorship/99953946 12 0.04761905 false false false Shariat Shahrokh true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953947 /api/authorship/99953947 13 0.04761905 false false false Author 10061833 /api/author/10061833 Küronya Zsófia true 10061833 true Kuronya Zsofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953948 /api/authorship/99953948 14 0.04761905 false false false Author 10038959 /api/author/10038959 Takács László Kristóf DUPLUM true 10038959 true Takacs Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953949 /api/authorship/99953949 15 0.04761905 false false false Author 10088809 /api/author/10088809 Tornyi Ilona true true Tornyi Ilona true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953950 /api/authorship/99953950 16 0.04761905 false false false Author 10017538 /api/author/10017538 Lázár József true 10017538 true Lazar Jozsef true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953951 /api/authorship/99953951 17 0.04761905 false false false Hadaschik Boris true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953952 /api/authorship/99953952 18 0.048 false false false Author 10025828 /api/author/10025828 Lászik András true 10025828 true Laszik Andras true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953953 /api/authorship/99953953 19 0.048 false false false Author 10024670 /api/author/10024670 Szűcs Miklós true 10024670 true Szucs Miklos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953954 /api/authorship/99953954 20 0.048 false false false Author 10013343 /api/author/10013343 Nyirády Péter true 10013343 true Nyirady Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99953955 /api/authorship/99953955 21 0.048 false true true Author 10052466 /api/author/10052466 Szarvas Tibor true 10052466 true Szarvas Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20390407 /api/publicationidentifier/20390407 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1111/jcmm.17141 https://doi.org/10.1111/jcmm.17141 false true PublicationIdentifier 20390408 /api/publicationidentifier/20390408 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000736442000001 https://www.webofscience.com/wos/woscc/full-record/000736442000001 false true PublicationIdentifier 20390456 /api/publicationidentifier/20390456 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85122081449 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85122081449 true true PublicationIdentifier 20390409 /api/publicationidentifier/20390409 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34970839 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34970839&dopt=Abstract false true Keyword 181 /api/keyword/181 true 181 true Keyword 1009833 /api/keyword/1009833 true 1009833 true Keyword 1011136 /api/keyword/1011136 true 1011136 true Keyword 1027454 /api/keyword/1027454 true 1027454 true Keyword 1056238 /api/keyword/1056238 true 1056238 true Keyword 1407252 /api/keyword/1407252 true 1407252 true Keyword 2345559 /api/keyword/2345559 true true Keyword 2356012 /api/keyword/2356012 true true Keyword 2561349 /api/keyword/2561349 true true SjrRating 11284215 /api/sjrrating/11284215 102 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1307 /api/classificationexternal/1307 true 1307 true Q2 DIRECT true true /api/publication/32585883 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10063755"><a href="/gui2/?type=authors&mode=browse&sel=10063755" target="_blank">Keresztes David (<span class="authorship-author-name">Keresztes Dávid</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064212"><a href="/gui2/?type=authors&mode=browse&sel=10064212" target="_blank">Csizmarik Anita (<span class="authorship-author-name">Pásztor-Csizmarik Anita</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079981"><a href="/gui2/?type=authors&mode=browse&sel=10079981" target="_blank">Nagy Nikolett (<span class="authorship-author-name">Habina-Nagy Nikolett</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048779"><a href="/gui2/?type=authors&mode=browse&sel=10048779" target="_blank">Modos Orsolya (<span class="authorship-author-name">Módos Orsolya</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073300"><a href="/gui2/?type=authors&mode=browse&sel=10073300" target="_blank">Fazekas Tamas (<span class="authorship-author-name">Fazekas Tamás</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bracht Thilo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sitek Barbara </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Witzke Kathrin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Puhr Martin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sevcenco Sabina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kramer Gero </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shariat Shahrokh </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061833"><a href="/gui2/?type=authors&mode=browse&sel=10061833" target="_blank">Kuronya Zsofia (<span class="authorship-author-name">Küronya Zsófia</span> <span class="authorAux-mtmt"> klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038959"><a href="/gui2/?type=authors&mode=browse&sel=10038959" target="_blank">Takacs Laszlo (<span class="authorship-author-name">Takács László Kristóf</span> <span class="authorAux-mtmt"> Genombiológia, immunológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Humángenetikai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088809"><a href="/gui2/?type=authors&mode=browse&sel=10088809" target="_blank">Tornyi Ilona (<span class="authorship-author-name">Tornyi Ilona</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017538"><a href="/gui2/?type=authors&mode=browse&sel=10017538" target="_blank">Lazar Jozsef (<span class="authorship-author-name">Lázár József</span> <span class="authorAux-mtmt"> sejtbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hadaschik Boris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025828"><a href="/gui2/?type=authors&mode=browse&sel=10025828" target="_blank">Laszik Andras (<span class="authorship-author-name">Lászik András</span> <span class="authorAux-mtmt"> igazságügyi orvostan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Igazságügyi és Biztosítás-orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024670"><a href="/gui2/?type=authors&mode=browse&sel=10024670" target="_blank">Szucs Miklos (<span class="authorship-author-name">Szűcs Miklós</span> <span class="authorAux-mtmt"> urológia, onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirady Peter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor ✉ (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32585883" target="_blank">Comparative proteome analysis identified CD44 as a possible serum marker for docetaxel resistance in castration-resistant prostate cancer</a></div> <div> <span class="journal-title">JOURNAL OF CELLULAR AND MOLECULAR MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1582-1838">1582-1838</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1582-4934">1582-4934</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">4</span> <span class="page"> pp 1332-1337 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1111/jcmm.17141" target="_blank" href="https://doi.org/10.1111/jcmm.17141"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000736442000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000736442000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85122081449" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85122081449"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34970839" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34970839&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 6 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;6 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32585883&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32585883</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (KFIH/FK 124431), (NVKP_16-1-2016-004), János Bolyai Research Scholarship of the Hungarian Academy of Sciences, (ÚNKP-20-5-SE-1), (UNKP-20-3-II-SE-8), (NTP-NFTÖ-20-B-0314) </div> <div class="lastModified">Utolsó módosítás: 2025.03.21. 10:34 Lázár József (sejtbiológia) </div> </div></div>