https://m2.mtmt.hu/ eng 2026-10-25 00:58 JournalArticle 32583377 APPROVED true 0 false 2026-10-22T01:52:04.338+0000 2026-05-20T13:36:44.521+0000 2022-01-10T09:42:36.060+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-09-03T09:06:06.610+0000 2026-09-03T09:06:06.610+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kővári, Dóra Tanycyte specific ablation of diacylglycerol lipase alpha stimulates the hypothalamic‐pituitary‐thyroid axis by decreasing the endocannabinoid mediated inhibition of TRH release true true /api/journal/2697 REVIEWED true false 2697 false 2697 true 0953-8194 1365-2826 Journal FOREIGN 34 1 e13079 e13079 9 2022 In addition to the hypophysiotropic thyrotropin‐releasing hormone (TRH)‐synthesizing neurons, a glial cell type, the tanycytes, also play a role in the regulation of the hypothalamic‐pituitary‐thyroid (HPT) axis. Tanycytes modulate the feedback regulation of the axis by regulating the local thyroid hormone availability in the median eminence where the hypophysiotropic axons terminate. Recently, we showed that tanycytes produce diacylglycerol lipase alpha (DAGLα), the synthesizing enzyme of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) that inhibits the release of TRH from the hypophysiotropic terminals in median eminence explants. To determine the importance of the endocannabinoid production of tanycytes, adult male Rax‐CreERT2//DAGLα<jats:sup>fl/fl</jats:sup> mice were treated with tamoxifen to induce a tanycyte specific decrease of DAGLα expression (T‐DAGLα KO). The effect of this genetic manipulation on the activity of the HPT axis was determined. Tanycyte specific decrease of DAGLα expression resulted in an approximately 2‐fold increase of TSHβ mRNA level that was accompanied by increased levels of circulating free T4. The TRH mRNA level was, however, not influenced by the genetic manipulation. In addition to the effects on the HPT axis, the T‐DAGLα KO mice showed increased fat mass ratio and decreased blood glucose levels. These data indicate that when endocannabinoid release of tanycytes is decreased, the disinhibition of the TRH release induces increased TSH synthesis and higher circulating T4 levels. Thus it suggests that in wild‐type mice, tanycytes exert a tonic inhibitory effect on the TRH release of hypophysiotropic axons. Furthermore, the endocannabinoid release of tanycytes also influences glucose homeostasis and fat deposition. 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10.1056/NEJMcp0801880 false true Reference 26435828 /api/reference/26435828 23 10.1210/jcem-58-6-960 false true /api/publication/32583377 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10053106"><a href="/gui2/?type=authors&mode=browse&sel=10053106" target="_blank">Kővári Dóra (<span class="authorship-author-name">Kővári Dóra</span> <span class="authorAux-mtmt"> neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Penksza Veronika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055055"><a href="/gui2/?type=authors&mode=browse&sel=10055055" target="_blank">Szilvásy‐Szabó Anett (<span class="authorship-author-name">Stiftné Szilvásy-Szabó Anett</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052876"><a href="/gui2/?type=authors&mode=browse&sel=10052876" target="_blank">Sinkó Richárd (<span class="authorship-author-name">Sinkó Richárd</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Cell Metabolism; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011473"><a href="/gui2/?type=authors&mode=browse&sel=10011473" target="_blank">Gereben Balázs (<span class="authorship-author-name">Gereben Balázs</span> <span class="authorAux-mtmt"> Pajzsmirigy endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Cell Metabolism; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mackie Ken </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete Csaba ✉ (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32583377" target="_blank">Tanycyte specific ablation of diacylglycerol lipase alpha stimulates the hypothalamic‐pituitary‐thyroid axis by decreasing the endocannabinoid mediated inhibition of TRH release</a></div> <div> <span class="journal-title">JOURNAL OF NEUROENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0953-8194">0953-8194</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1365-2826">1365-2826</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">1</span> <span class="page"> Paper e13079. 9 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/jne.13079" target="_blank" href="https://doi.org/10.1111/jne.13079"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000736523500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000736523500001"> WoS </a> </span> <span class="id identifier oa_CLOSED" title=" Closed "> <a style="color:black" title="164365" target="_blank" href="https://real.mtak.hu/164365"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85122084623" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85122084623"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34970803" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34970803&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrine and Autonomic Systems&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 10</span> | Independent citation: 10 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;10 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32583377&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32583377</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), EU H2020 THYRAGE(No. 666869), Hungarian Science Foundation(OTKA K124767), (K125247) Funder: HSRF </div> <div class="lastModified">Last Modified: 2026.05.20. 15:36 Márta Turek (KOKI admin 4) </div> </div></div>