https://m2.mtmt.hu/ eng 2026-10-25 03:42 JournalArticle 32568337 VALIDATED true Export Date: 29 April 2026; Cited By: 5; Correspondence Address: Z. Németh; Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Budapest, Hungary; email: nemeth.zsolt@dent.semmelweis-univ.hu; CODEN: POREF; 0 false 2026-10-22T01:31:00.544+0000 2026-04-29T06:15:54.707+0000 2022-01-04T20:46:02.553+0000 true 10018804 Szalóky-Siki Ágnes /api/admin/10018804 Admin true 10018804 2026-04-29T06:15:54.650+0000 2022-01-04T20:52:09.433+0000 true 10018804 Szalóky-Siki Ágnes /api/admin/10018804 Admin true 10018804 2022-02-09T08:20:49.678+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Csurgay, Katalin A Study of Prognostic Factors in Young Patients With Non-HPV Oral Cancer in Central Europe true true /api/journal/1035680 REVIEWED true false 1035680 false 1035680 true 1219-4956 1532-2807 Journal FOREIGN_AND_HUNGARIAN 27 1609991 1609991 11 2021 The etiological factors of squamous cell carcinomas of the head and neck have been well known for a long time. It is also well known that the incidence of oral cancer diagnosed in younger patients is on the rise. Due to the young age of these patients, the increase in the number of these cases and the fact that many of them neither smoke nor drink alcohol it has been suggested that other factors might be at play in the carcinogenesis of oral cancer. Thus, along the classic etiological factors of smoking and alcohol abuse certain molecular marker anomalies and the human papilloma virus (HPV) have emerged as potential factors. The aim of the present study is to verify the potential prognostic factors and to map the differences in biomarker expression between the young and the old patient groups. In the present study the immunohistochemical profile of samples obtained from oral squamous cell carcinomas was studied and compared with various clinico-pathological parameters. In 88 samples the expressions of p16, p53, Ki67, EGFR were studied with a tissue microarray technique under standard reaction conditions as well as the detection and typing of HPV infection with the Full Spectrum HPV DNA method. The biomarker expression profile of young patients with oral squamous cell carcinoma was compared to that of older patients (above 50). A significant difference was found between the immunohistochemical profile of the young and old patient groups in p16, Ki67 expression. The overall survival and progression free survival were influenced by p16 expression in young age. Funding 2008418 /api/funding/2008418 false true true 2022 true true true false true false NONE 2026-10-22 false 5 0 5 5 3 5 5 5 5 5 5 5 5 5 0 0 5 5 5 5 0 9 9 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 1 1 1 1 2025 0 1 1 1 1 2026 0 2 2 2 2 Q2 false 10012525 false false false 2022-01-03T20:52:09.275+0000 Arc- Állcsont- Szájsebészeti és Fogászati Klinika (SE / FOK); I. 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Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Konzerváló Fogászati Klinika (SE / FOK); Népegészségtani Intézet (SE / AOK / I) 6 24 4 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 99869931 /api/authorship/99869931 1 0.125 true false false Author 10039578 /api/author/10039578 Csurgay Katalin true 10039578 true Csurgay Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99869932 /api/authorship/99869932 2 0.125 false false false Author 10023569 /api/author/10023569 Zalatnai Attila true 10023569 true Zalatnai Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99869933 /api/authorship/99869933 3 0.125 false false false Benczik Márta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99869934 /api/authorship/99869934 4 0.125 false false false Author 10061514 /api/author/10061514 Csomó Krisztián Benedek true 10061514 true Csomó Benedek Krisztián true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99869935 /api/authorship/99869935 5 0.125 false false false Author 10024114 /api/author/10024114 Horváth Ferenc true 10024114 true Horváth Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99869936 /api/authorship/99869936 6 0.125 false false false Lőrincz Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99869937 /api/authorship/99869937 7 0.125 false false false Author 10045594 /api/author/10045594 Komlós György true 10045594 true Komlós György true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99869938 /api/authorship/99869938 8 0.125 false true true Author 10012525 /api/author/10012525 Németh Zsolt true 10012525 true Németh Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20355524 /api/publicationidentifier/20355524 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3389/pore.2021.1609991 https://doi.org/10.3389/pore.2021.1609991 false true PublicationIdentifier 20511289 /api/publicationidentifier/20511289 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000745248500001 https://www.webofscience.com/wos/woscc/full-record/000745248500001 true true PublicationIdentifier 20409120 /api/publicationidentifier/20409120 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85122345760 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85122345760 false true PublicationIdentifier 20420447 /api/publicationidentifier/20420447 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 35002542 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35002542&dopt=Abstract true true PublicationIdentifier 31920418 /api/publicationidentifier/31920418 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/pages/publications/85122345760?origin=resultslist https://www.scopus.com/pages/publications/85122345760?origin=resultslist false true Classification 12124 /api/classification/12124 true true SjrRating 11225850 /api/sjrrating/11225850 968 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q2 DIRECT true true /api/publication/32568337 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10039578"><a href="/gui2/?type=authors&mode=browse&sel=10039578" target="_blank">Csurgay Katalin (<span class="authorship-author-name">Csurgay Katalin</span> <span class="authorAux-mtmt"> dentoalveoláris sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oro-Maxillofacial Surgery and Stomatology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023569"><a href="/gui2/?type=authors&mode=browse&sel=10023569" target="_blank">Zalatnai Attila (<span class="authorship-author-name">Zalatnai Attila</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/I. Department of Pathology and experimental Cancer Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Benczik Márta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061514"><a href="/gui2/?type=authors&mode=browse&sel=10061514" target="_blank">Csomó Benedek Krisztián (<span class="authorship-author-name">Csomó Krisztián Benedek</span> <span class="authorAux-mtmt"> Konzerváló Fogászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oro-Maxillofacial Surgery and Stomatology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Conservative Dentistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024114"><a href="/gui2/?type=authors&mode=browse&sel=10024114" target="_blank">Horváth Ferenc (<span class="authorship-author-name">Horváth Ferenc</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lőrincz Ádám </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045594"><a href="/gui2/?type=authors&mode=browse&sel=10045594" target="_blank">Komlós György (<span class="authorship-author-name">Komlós György</span> <span class="authorAux-mtmt"> Szájsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oro-Maxillofacial Surgery and Stomatology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012525"><a href="/gui2/?type=authors&mode=browse&sel=10012525" target="_blank">Németh Zsolt ✉ (<span class="authorship-author-name">Németh Zsolt</span> <span class="authorAux-mtmt"> Arc-állcsont-szájsebészet, onkológia, implantol...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oro-Maxillofacial Surgery and Stomatology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32568337" target="_blank">A Study of Prognostic Factors in Young Patients With Non-HPV Oral Cancer in Central Europe</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1219-4956">1219-4956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2807">1532-2807</a>)</span>: <span class="journal-volume">27</span> <span class="page"> Paper 1609991. 11 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/pore.2021.1609991" target="_blank" href="https://doi.org/10.3389/pore.2021.1609991"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000745248500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000745248500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85122345760" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85122345760"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35002542" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35002542&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85122345760?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85122345760?origin=resultslist"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 5</span> | Independent citation: 5 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32568337&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32568337</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (Faculty of Dentistry, Semmelweis University) </div> <div class="lastModified">Last Modified: 2026.04.29. 08:15 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Export Date: 29 April 2026; Cited By: 5; Correspondence Address: Z. Németh; Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Budapest, Hungary; email: nemeth.zsolt@dent.semmelweis-univ.hu; CODEN: POREF;</pre> </div></div>