https://m2.mtmt.hu/ eng 2026-05-31 16:23 JournalArticle 32552757 VALIDATED true 0 false 2026-05-21T11:22:35.458+0000 2025-12-01T12:31:19.306+0000 2021-12-29T09:23:17.210+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) true 2025-12-01T12:24:12.598+0000 2025-12-01T12:24:12.598+0000 2025-12-01T12:31:19.525+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Tamásné Gere (SE_KK_Admin5_GT, admin) true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Barta, Bálint András true true /api/journal/10007133 REVIEWED JOURNAL OF TRANSLATIONAL MEDICINE 1479-5876 1479-5876 true false 10007133 false 10007133 true 1479-5876 1479-5876 Journal FOREIGN 19 1 507 507 15 2021 Background: Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory responses, mitochondrial proteins, extracellular remodeling and estrogen-mediated cardioprotective signaling pathways related to post-ischemic recovery, which were associated with better cardiac functional outcomes in females. We aimed to investigate the early, sex-specific functional and proteomic changes following myocardial ischemia in an unbiased approach. Methods: Ischemia was induced in male (M-Isch) and female (F-Isch) rats with sc. injection of isoproterenol (85 mg/kg) daily for 2 days, while controls (M-Co, F-Co) received sc. saline solution. At 48 h after the first injection pressure-volume analysis was carried out to assess left ventricular function. FFPE tissue slides were scanned and analyzed digitally, while myocardial proteins were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) using isobaric labeling. Concentrations of circulating steroid hormones were measured with LC-MS/MS. Feature selection (PLS and PLS-DA) was used to examine associations among functional, proteomic and hormonal datasets. Results: Induction of ischemia resulted in 38% vs 17% mortality in M-Isch and F-Isch respectively. The extent of ischemic damage to surviving rats was comparable between the sexes. Systolic dysfunction was more pronounced in males, while females developed a more severe impairment of diastolic function. 2224 proteins were quantified, with 520 showing sex-specific differential regulation. Our analysis identified transcriptional, cytoskeletal, contractile, and mitochondrial proteins, molecular chaperones and the extracellular matrix as sources of disparity between the sexes. Bioinformatics highlighted possible associations of estrogens and their metabolites with early functional and proteomic alterations. Conclusions: Our study has highlighted sex-specific alterations in systolic and diastolic function shortly after ischemia, and provided a comprehensive look at the underlying proteomic changes and the influence of estrogens and their metabolites. According to our bioinformatic analysis, inflammatory, mitochondrial, chaperone, cytoskeletal, extracellular and matricellular proteins are major sources of intersex disparity, and may be promising targets for early sex-specific pharmacologic interventions. Funding 2012787 /api/funding/2012787 (Open access funding provided by Semmelweis University) false true Funding 2012788 /api/funding/2012788 (ÚNKP-20-3-I-SE-1) false true Funding 2012789 /api/funding/2012789 Nemzeti szívprogram(NVKP_16-1–2016-0017) Funder: NRDIO false true Funding 2012790 /api/funding/2012790 (2020-4.1.1.-TKP2020) false true Funding 2012791 /api/funding/2012791 National Research, Development and Innovation Office (NKFIH) of Hungary(K134939) false true true 2021 true true true false true false GOLD 2026-05-21 true https://doi.org/10.1186/s12967-021-03164-y 9 0 9 7 2 8 9 7 9 9 9 7 7 7 2 0 9 7 9 7 0 3 3 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 0 1 0 2023 0 1 1 1 1 2024 0 2 1 2 1 2025 0 5 5 5 5 D1 false 10069723 false false false 2021-12-28T09:28:51.248+0000 Laboratóriumi Medicina Intézet (SE / AOK / I); Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 8 41 3 12 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 99777657 /api/authorship/99777657 Barta, Bálint András ✉ [Barta, Bálint András (Experimentális ka...), author] Cardiovascular Center (SU / FM / C) 1 0.083 true false true Author 10072454 /api/author/10072454 Bálint András Barta (Experimentális kardiológia, Proteomika) Barta Bálint András true true Barta Bálint András true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777658 /api/authorship/99777658 Ruppert, Mihály [Ruppert, Mihály (orvostudomány), author] Cardiovascular Center (SU / FM / C) 2 0.083 false false false Author 10060212 /api/author/10060212 Mihály Ruppert (orvostudomány) Ruppert Mihály true 10060212 true Ruppert Mihály true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777659 /api/authorship/99777659 Frohlich, Klemens Erwin 3 0.083333336 false false false Frohlich Klemens Erwin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777660 /api/authorship/99777660 Cosenza-Contreras, Miguel 4 0.083333336 false false false Cosenza-Contreras Miguel true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777661 /api/authorship/99777661 Oláh, Attila [Oláh, Attila (kardiológia, inte...), author] Cardiovascular Center (SU / FM / C) 5 0.083 false false false Author 10045523 /api/author/10045523 Attila Oláh (kardiológia, intervenciós kardiológia) Oláh Attila true 10045523 true Oláh Attila true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777662 /api/authorship/99777662 Sayour, Alex Ali [Sayour, Alex Ali (kardiológia), author] Cardiovascular Center (SU / FM / C) 6 0.083 false false false Author 10069723 /api/author/10069723 Alex Ali Sayour (kardiológia) Sayour Alex Ali true true Sayour Alex Ali true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777663 /api/authorship/99777663 Kovács, Krisztián [Kovács, Krisztián (Molekuláris biológia), author] Department of Laboratory Medicine (SU / FM / I) 7 0.083 false false false Author 10033055 /api/author/10033055 Krisztián Kovács (Molekuláris biológia) Kovács Krisztián true 10033055 true Kovács Krisztián true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777664 /api/authorship/99777664 Karvaly, Gellért Balázs [Karvaly, Gellért Balázs (klinikai kémia), author] Department of Laboratory Medicine (SU / FM / I) 8 0.083 false false false Author 10049015 /api/author/10049015 Gellért Balázs Karvaly (klinikai kémia) Karvaly Gellért Balázs true 10049015 true Karvaly Gellért Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777665 /api/authorship/99777665 Biniossek, Martin 9 0.083333336 false false false Biniossek Martin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777666 /api/authorship/99777666 Merkely, Béla [Merkely, Béla Péter (Kardiológia), author] Cardiovascular Center (SU / FM / C); Faculty of Sports Medicine (SU / FM / C) 10 0.083 false false false Author 10002691 /api/author/10002691 Béla Péter Merkely (Kardiológia) Merkely Béla Péter true 10002691 true Merkely Béla true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777667 /api/authorship/99777667 Schilling, Oliver** 11 0.083 false true false Schilling Oliver true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99777668 /api/authorship/99777668 Radovits, Tamás [Radovits, Tamás (kardiológia, érgy...), author] Cardiovascular Center (SU / FM / C) 12 0.083 false true false Author 10013969 /api/author/10013969 Tamás Radovits (kardiológia, érgyógyászat) Radovits Tamás true 10013969 true Radovits Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 20323672 /api/publicationidentifier/20323672 DOI: 10.1186/s12967-021-03164-y PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s12967-021-03164-y https://doi.org/10.1186/s12967-021-03164-y false true PublicationIdentifier 20323673 /api/publicationidentifier/20323673 WoS: 000729234200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000729234200001 https://www.webofscience.com/wos/woscc/full-record/000729234200001 false true PublicationIdentifier 20323675 /api/publicationidentifier/20323675 Scopus: 85121378107 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85121378107 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85121378107 false true PublicationIdentifier 20323674 /api/publicationidentifier/20323674 PubMed: 34895263 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 34895263 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34895263&dopt=Abstract false true Keyword 64 /api/keyword/64 Inflammation true 64 true Keyword 574 /api/keyword/574 INFARCTION true 574 true Keyword 621 /api/keyword/621 ACTIVATION true 621 true Keyword 1452 /api/keyword/1452 MATRIX true 1452 true Keyword 1882 /api/keyword/1882 REPERFUSION INJURY true 1882 true Keyword 2917 /api/keyword/2917 ESTROGEN true 2917 true Keyword 4791 /api/keyword/4791 HEART true 4791 true Keyword 1001661 /api/keyword/1001661 GENDER-DIFFERENCES true 1001661 true Keyword 1001905 /api/keyword/1001905 MYOCARDIAL ISCHEMIA true 1001905 true Keyword 1053027 /api/keyword/1053027 17-BETA-ESTRADIOL true 1053027 true Keyword 1060923 /api/keyword/1060923 sex differences true 1060923 true Keyword 1501093 /api/keyword/1501093 Left ventricular function true true Keyword 2549910 /api/keyword/2549910 Proteomic changes true true SjrRating 11225046 /api/sjrrating/11225046 sjr:D1 (2021) Scopus - Medicine (miscellaneous) JOURNAL OF TRANSLATIONAL MEDICINE 1479-5876 211 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true D1 DIRECT true true /api/publication/32552757 Barta Bálint András et al. Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia. (2021) JOURNAL OF TRANSLATIONAL MEDICINE 1479-5876 1479-5876 19 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10072454"><a href="/gui2/?type=authors&mode=browse&sel=10072454" target="_blank">Barta Bálint András ✉ (<span class="authorship-author-name">Barta Bálint András</span> <span class="authorAux-mtmt"> Experimentális kardiológia, Proteomika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060212"><a href="/gui2/?type=authors&mode=browse&sel=10060212" target="_blank">Ruppert Mihály (<span class="authorship-author-name">Ruppert Mihály</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Frohlich Klemens Erwin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cosenza-Contreras Miguel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045523"><a href="/gui2/?type=authors&mode=browse&sel=10045523" target="_blank">Oláh Attila (<span class="authorship-author-name">Oláh Attila</span> <span class="authorAux-mtmt"> kardiológia, intervenciós kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069723"><a href="/gui2/?type=authors&mode=browse&sel=10069723" target="_blank">Sayour Alex Ali (<span class="authorship-author-name">Sayour Alex Ali</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10033055"><a href="/gui2/?type=authors&mode=browse&sel=10033055" target="_blank">Kovács Krisztián (<span class="authorship-author-name">Kovács Krisztián</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Laboratory Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049015"><a href="/gui2/?type=authors&mode=browse&sel=10049015" target="_blank">Karvaly Gellért Balázs (<span class="authorship-author-name">Karvaly Gellért Balázs</span> <span class="authorAux-mtmt"> klinikai kémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Laboratory Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Biniossek Martin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Faculty of Sports Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schilling Oliver^** </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013969"><a href="/gui2/?type=authors&mode=browse&sel=10013969" target="_blank">Radovits Tamás (<span class="authorship-author-name">Radovits Tamás</span> <span class="authorAux-mtmt"> kardiológia, érgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32552757" target="_blank">Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia</a></div> <div> <span class="journal-title">JOURNAL OF TRANSLATIONAL MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1479-5876">1479-5876</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1479-5876">1479-5876</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">1</span> <span class="page"> Paper 507. 15 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12967-021-03164-y" target="_blank" href="https://doi.org/10.1186/s12967-021-03164-y"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000729234200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000729234200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85121378107" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85121378107"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34895263" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34895263&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 9</span> | Independent citation: 7 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;9 | WoS/Scopus assigned:&nbsp;9 | Number of citations with DOI:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32552757&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32552757</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (ÚNKP-20-3-I-SE-1), National Heart Program(NVKP-16-1-2016-0017) Funder: NRDIO, (2020-4.1.1-TKP2020) Funder: NRDIO, National Research, Development and Innovation Office (NKFIH) of Hungary(K134939) </div> <div class="lastModified">Last Modified: 2025.12.01. 13:31 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> </div></div>