Early goal-directed treatment is an evidence-based approach to guide hemostatic therapy
during major periprocedural bleeding. If viscoelastic coagulation tests are not available,
an algorithm, termed the pyramid of hemostatic interventions, can help manage severe
bleeding. Pregnant women accumulate huge reserves of prothrombotic and antifibrinolytic
hemostatic elements to avoid peripartum blood loss. We provide comparison of therapeutic
hemostatic approaches and natural gestational process and identified remarkable analogy
between early goal-directed management of bleeding and hemostatic adaptation of pregnant
woman. Therefore, gestational hemostasis serves as a natural model for goal-directed
hemostasis resuscitation and can foster understanding of hemostatic management of
periprocedural bleeding.
