https://m2.mtmt.hu/ hun 2026-10-24 02:10 JournalArticle 32551577 VALIDATED true Department of Radiobiology and Diagnostic Onco-Cytogenetics, Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary Department of Oncology, Semmelweis University, Budapest, Hungary Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary Export Date: 11 October 2023 Correspondence Address: Major, T.; Department of Oncology, Hungary; email: major.tibor@med.semmelweis-univ.hu 0 false 2026-10-22T00:42:11.769+0000 2022-11-16T12:51:36.877+0000 2021-12-28T07:12:16.190+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2023-10-11T08:09:02.791+0000 2022-11-16T12:51:37.143+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080105 /api/admin/10080105 Kériné Tornyi Katalin true true 2024-10-17T16:16:12.275+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kocsis, Zsuzsa S Relationship between biodosimetric parameters and treatment volumes in three types of prostate radiotherapy true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 11 1 24406 24406 10 2021 Brachytherapy (BT) and external beam radiotherapy (EBRT) apply different dose rates, overall treatment times, energies and fractionation. However, the overall impact of these variables on the biological dose of blood is neglected. As the size of the irradiated volume influences the biological effect as well, we studied chromosome aberrations (CAs) as biodosimetric parameters, and explored the relationship of isodose surface volumes (ISVs: V1%, V1Gy, V10%, V10Gy, V100%, V150%) and CAs of both irradiation modalities. We performed extended dicentrics assay of lymphocytes from 102 prostate radiotherapy patients three-monthly for a year. Aberration frequency was the highest after EBRT treatment. It increased after the therapy and did not decrease significantly during the first follow-up year. We showed that various types of CAs 9 months after LDR BT, 3 months after HDR BT and in a long time-range (even up to 1 year) after EBRT positively correlated with ISVs. Regression analysis confirmed these relationships in the case of HDR BT and EBRT. The observed differences in the time points and aberration types are discussed. The ISVs irradiated by EBRT showed stronger correlation and regression relationships with CAs than the ISVs of brachytherapy. 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1 1 1 1 2026 0 3 2 3 2 D1 A nemzetközi false 10011699,10010426 false false false 2022-01-04T10:23:57.329+0000 Onkológiai Tanszék (SE / AOK / K); Országos Onkológiai Intézet 13 31 2 13 0 true 10080105 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 99739121 /api/authorship/99739121 1 0.077 true false false Author 10020433 /api/author/10020433 Kocsis Zsuzsa true 10020433 true Kocsis Zsuzsa S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99739122 /api/authorship/99739122 2 0.077 false false true Author 10044386 /api/author/10044386 Major Tibor true 10044386 true Major Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99739123 /api/authorship/99739123 3 0.077 false false false Author 10018107 /api/author/10018107 Pesznyák Csilla true 10018107 true Pesznyák Csilla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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/api/authorship/99739128 8 0.077 false false false Author 10032265 /api/author/10032265 Székely Gábor true 10032265 true Székely Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99739129 /api/authorship/99739129 9 0.077 false false false Author 10030572 /api/author/10030572 Ágoston Péter Zoltán true 10030572 true Ágoston Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99739130 /api/authorship/99739130 10 0.077 false false false Author 10064469 /api/author/10064469 Jorgo Kliton true 10064469 true Jorgo Kliton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99739131 /api/authorship/99739131 11 0.077 false false false Author 10058289 /api/author/10058289 Gesztesi László true 10058289 true Gesztesi László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99739132 /api/authorship/99739132 12 0.077 false false false Author 10013383 /api/author/10013383 Polgár Csaba true 10013383 true Polgár Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99739133 /api/authorship/99739133 13 0.077 false true false Author 10010426 /api/author/10010426 Jurányi Zsolt true 10010426 true Jurányi Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20320956 /api/publicationidentifier/20320956 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41598-021-03417-2 https://doi.org/10.1038/s41598-021-03417-2 false true PublicationIdentifier 20366001 /api/publicationidentifier/20366001 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34949762&dopt=Abstract false true MtaRating 519359 /api/mtarating/519359 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi true true SjrRating 11184995 /api/sjrrating/11184995 11 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/32551577 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020433"><a href="/gui2/?type=authors&mode=browse&sel=10020433" target="_blank">Kocsis Zsuzsa S (<span class="authorship-author-name">Kocsis Zsuzsa</span> <span class="authorAux-mtmt"> sugárbiológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044386"><a href="/gui2/?type=authors&mode=browse&sel=10044386" target="_blank">Major Tibor ✉ (<span class="authorship-author-name">Major Tibor</span> <span class="authorAux-mtmt"> klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018107"><a href="/gui2/?type=authors&mode=browse&sel=10018107" target="_blank">Pesznyák Csilla (<span class="authorship-author-name">Pesznyák Csilla</span> <span class="authorAux-mtmt"> Orvosfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065843"><a href="/gui2/?type=authors&mode=browse&sel=10065843" target="_blank">Mihály Dalma (<span class="authorship-author-name">Mihály Dalma</span> <span class="authorAux-mtmt"> Klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042823"><a href="/gui2/?type=authors&mode=browse&sel=10042823" target="_blank">Stelczer Gábor (<span class="authorship-author-name">Stelczer Gábor</span> <span class="authorAux-mtmt"> Orvosfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071423"><a href="/gui2/?type=authors&mode=browse&sel=10071423" target="_blank">Kun-Gazda Márta (<span class="authorship-author-name">Kun-Gazda Márta</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011699"><a href="/gui2/?type=authors&mode=browse&sel=10011699" target="_blank">Farkas Gyöngyi (<span class="authorship-author-name">Farkas Gyöngyi</span> <span class="authorAux-mtmt"> Környezeti mikrobiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032265"><a href="/gui2/?type=authors&mode=browse&sel=10032265" target="_blank">Székely Gábor (<span class="authorship-author-name">Székely Gábor</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030572"><a href="/gui2/?type=authors&mode=browse&sel=10030572" target="_blank">Ágoston Péter (<span class="authorship-author-name">Ágoston Péter Zoltán</span> <span class="authorAux-mtmt"> Sugárterápia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064469"><a href="/gui2/?type=authors&mode=browse&sel=10064469" target="_blank">Jorgo Kliton (<span class="authorship-author-name">Jorgo Kliton</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058289"><a href="/gui2/?type=authors&mode=browse&sel=10058289" target="_blank">Gesztesi László (<span class="authorship-author-name">Gesztesi László</span> <span class="authorAux-mtmt"> Sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgár Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010426"><a href="/gui2/?type=authors&mode=browse&sel=10010426" target="_blank">Jurányi Zsolt (<span class="authorship-author-name">Jurányi Zsolt</span> <span class="authorAux-mtmt"> Onkológiai kutatás, sugárterápia, sugárbiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32551577" target="_blank">Relationship between biodosimetric parameters and treatment volumes in three types of prostate radiotherapy</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">1</span> <span class="page"> Paper 24406. 10 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span 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Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 5 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32551577&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32551577</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (TKP2020-NKA-26), (K-034416, NLP-17) </div> <div class="lastModified">Utolsó módosítás: 2022.11.16. 13:51 Molnár-Taga Márta (SE 4-es admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:16 Ladányi Gusztáv (MTMT API user, admin) Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Radiobiology and Diagnostic Onco-Cytogenetics, Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary Department of Oncology, Semmelweis University, Budapest, Hungary Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary Export Date: 11 October 2023 ...</pre> </div></div>