https://m2.mtmt.hu/ hun 2026-04-30 01:02 JournalArticle 3254659 VALIDATED true 0 2018-09-24T22:20:07.000+0000 false 3254659 2026-04-28T12:01:11.778+0000 2026-02-05T08:43:02.947+0000 2017-08-15T11:00:31.000+0000 true 10014559 Bolgár Andrea /api/admin/10014559 Admin Bolgár Andrea (MFA admin 4) true 10014559 2026-02-05T08:43:04.131+0000 2026-02-05T08:43:04.131+0000 2026-02-04T22:24:31.595+0000 true 10063514 Mikola Katalin /api/admin/10063514 Admin Mikola Katalin (MTMT 3, admin) true 10063514 Admin 10063514 /api/admin/10063514 Mikola Katalin (MTMT 3, admin) Mikola Katalin true 10063514 true 2026-01-21T13:12:53.998+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Németh, Andrea true true /api/journal/10019966 REVIEWED SCIENTIFIC REPORTS 2045-2322 true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 7 1 8202 8202 16 2017 Recently, biological roles of extracellular vesicles (which include among others exosomes, microvesicles and apoptotic bodies) have attracted substantial attention in various fields of biomedicine. Here we investigated the impact of sustained exposure of cells to the fluoroquinolone antibiotic ciprofloxacin on the released extracellular vesicles. Ciprofloxacin is widely used in humans against bacterial infections as well as in cell cultures against <jats:italic>Mycoplasma</jats:italic> contamination. However, ciprofloxacin is an inducer of oxidative stress and mitochondrial dysfunction of mammalian cells. Unexpectedly, here we found that ciprofloxacin induced the release of both DNA (mitochondrial and chromosomal sequences) and DNA-binding proteins on the exofacial surfaces of small extracellular vesicles referred to in this paper as exosomes. Furthermore, a label-free optical biosensor analysis revealed DNA-dependent binding of exosomes to fibronectin. DNA release on the surface of exosomes was not affected any further by cellular activation or apoptosis induction. Our results reveal for the first time that prolonged low-dose ciprofloxacin exposure leads to the release of DNA associated with the external surface of exosomes. Funding 2063397 /api/funding/2063397 Hungarian Scientific Research Fund(11958) Támogató: OTKA false true Funding 2062280 /api/funding/2062280 (FP7-PEOPLE-2011-ITN-PITN-GA-2011-289033 DYNANO) false true Funding 2062279 /api/funding/2062279 (PD112085) false true Funding 2062278 /api/funding/2062278 (PD104369) false true Funding 2062277 /api/funding/2062277 (NVKP_16-1-2016-0007) Támogató: NKFIH false true Funding 2062276 /api/funding/2062276 National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH false true Funding 2062275 /api/funding/2062275 (OTKA PD 109051) false true Funding 2062274 /api/funding/2062274 (120237) Támogató: OTKA false true Funding 2062273 /api/funding/2062273 Hungarian Scientific Research Fund(11958) Támogató: OTKA false true true 2017 true true true false true false GOLD 2026-04-28 true https://doi.org/10.1038/s41598-017-08392-1 151 0 139 124 19 144 139 136 135 139 136 124 121 134 17 0 151 134 139 124 0 15 15 Folyóiratcikk Journal Article 24 131 Könyvrészlet Chapter in Book 25 7 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 12 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2017 0 3 2 3 2 2018 0 11 8 11 8 2019 0 18 15 18 15 2020 0 15 15 15 15 2021 0 21 19 21 19 2022 0 29 26 29 26 2023 0 13 12 13 12 2024 0 25 23 25 23 2025 0 13 11 13 11 2026 0 3 3 3 3 D1 A nemzetközi false 10015596,10027645,10040711,10015603 false false false 2018-09-24T15:10:38.000+0000 2017-08-15T11:06:22.000+0000 Fotonika Laboratórium (HUN-REN EK / MFA); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Lendület Nanobioszenzorika Kutatócsoport (HUN-REN EK / MFA); Molekuláris Farmakológia Kutatócsoport (KOKI / GYO); Műszaki Fizikai és Anyagtudományi Intézet (HUN-REN EK); Szerves Kémiai Intézet (MTA TTK) 15 59 6 15 0 true 10063514 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 9253840 /api/authorship/9253840 Németh, Andrea [Németh, Andrea (immunológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 1 0.06666667 true false Author 10032263 /api/author/10032263 Németh Andrea (immunológia) Németh Andrea true 10032263 true Németh Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 26696485 true PersonAuthorship 9253841 /api/authorship/9253841 Orgovan, Norbert [Orgován, Norbert (biofizika), szerző] Műszaki Fizikai és Anyagtudományi Intézet (HUN-REN EK); Fotonika Laboratórium (HUN-REN EK / MFA) 2 0.06666667 false false Author 10035179 /api/author/10035179 Orgován Norbert (biofizika) Orgován Norbert true 10035179 true Orgovan Norbert true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 26696484 true PersonAuthorship 9253842 /api/authorship/9253842 Sódar, Barbara W [Sódar, Barbara (immunológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 3 0.067 false false Author 10043376 /api/author/10043376 Sódar Barbara (immunológia) Sódar Barbara true 10043376 true Sódar Barbara W true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 26696483 true PersonAuthorship 9253843 /api/authorship/9253843 Osteikoetxea, Xabier [Osteikoetxea, Xabier (immunológia, gene...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 4 0.06666667 false false Author 10052584 /api/author/10052584 Osteikoetxea Xabier (immunológia, genetika) Osteikoetxea Xabier true 10052584 true Osteikoetxea Xabier true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 26696482 true PersonAuthorship 9253844 /api/authorship/9253844 Pálóczi, Krisztina [Pálóczi, Krisztina (immunológia, gene...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 5 0.06666667 false false Author 10024466 /api/author/10024466 Pálóczi Krisztina (immunológia, genetika) Pálóczi Krisztina true 10024466 true Pálóczi Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 26696481 true PersonAuthorship 9253845 /api/authorship/9253845 Szabó-Taylor, Katalin É [Szabó-Taylor, Katalin (Immunológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 6 0.067 false false Author 10027645 /api/author/10027645 Szabó-Taylor Katalin (Immunológia) Szabó-Taylor Katalin true 10027645 true Szabó-Taylor Katalin É true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 26696480 true PersonAuthorship 9253846 /api/authorship/9253846 Vukman, Krisztina V [Visnovitzné Dr Vukman, Krisztina 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(2017) SCIENTIFIC REPORTS 2045-2322 7 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10032263"><a href="/gui2/?type=authors&mode=browse&sel=10032263" target="_blank">Németh Andrea (<span class="authorship-author-name">Németh Andrea</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035179"><a href="/gui2/?type=authors&mode=browse&sel=10035179" target="_blank">Orgovan Norbert (<span class="authorship-author-name">Orgován Norbert</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="MTA Energiatudományi Kutatóközpont">MTA EK</span>/Műszaki Fizikai és Anyagtudományi Intézet; <span title="MTA Energiatudományi Kutatóközpont">MTA EK</span>/<span title="Műszaki Fizikai és Anyagtudományi Intézet">MFA</span>/Fotonika Laboratórium</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043376"><a href="/gui2/?type=authors&mode=browse&sel=10043376" target="_blank">Sódar Barbara W (<span class="authorship-author-name">Sódar Barbara</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052584"><a href="/gui2/?type=authors&mode=browse&sel=10052584" target="_blank">Osteikoetxea Xabier (<span class="authorship-author-name">Osteikoetxea Xabier</span> <span class="authorAux-mtmt"> immunológia, genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024466"><a href="/gui2/?type=authors&mode=browse&sel=10024466" target="_blank">Pálóczi Krisztina (<span class="authorship-author-name">Pálóczi Krisztina</span> <span class="authorAux-mtmt"> immunológia, genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027645"><a href="/gui2/?type=authors&mode=browse&sel=10027645" target="_blank">Szabó-Taylor Katalin É (<span class="authorship-author-name">Szabó-Taylor Katalin</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040711"><a href="/gui2/?type=authors&mode=browse&sel=10040711" target="_blank">Vukman Krisztina V (<span class="authorship-author-name">Visnovitzné Dr Vukman Krisztina</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009113"><a href="/gui2/?type=authors&mode=browse&sel=10009113" target="_blank">Kittel Ágnes (<span class="authorship-author-name">Kittel Ágnes</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">MTAKOKI</span>/<span title="Gyógyszerkutatási Osztály">GYO</span>/Molekuláris Farmakológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024570"><a href="/gui2/?type=authors&mode=browse&sel=10024570" target="_blank">Turiák Lilla (<span class="authorship-author-name">Turiák Lilla</span> <span class="authorAux-mtmt"> tömegspektrometria, proteomika</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Szerves Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012601"><a href="/gui2/?type=authors&mode=browse&sel=10012601" target="_blank">Wiener Zoltán (<span class="authorship-author-name">Wiener Zoltán</span> <span class="authorAux-mtmt"> Sejtbiológia, tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015603"><a href="/gui2/?type=authors&mode=browse&sel=10015603" target="_blank">Tóth Sára (<span class="authorship-author-name">Tóth Sára</span> <span class="authorAux-mtmt"> őssejt</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002323"><a href="/gui2/?type=authors&mode=browse&sel=10002323" target="_blank">Drahos László (<span class="authorship-author-name">Drahos László</span> <span class="authorAux-mtmt"> proteomika, tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Szerves Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002353"><a href="/gui2/?type=authors&mode=browse&sel=10002353" target="_blank">Vékey Károly (<span class="authorship-author-name">Vékey Károly</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/Szerves Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002473"><a href="/gui2/?type=authors&mode=browse&sel=10002473" target="_blank">Horvath Robert (<span class="authorship-author-name">Horváth Róbert</span> <span class="authorAux-mtmt"> Bioszenzorok</span>) </a> </span> <span class="author-affil"><span title="MTA Energiatudományi Kutatóközpont">MTA EK</span>/<span title="Műszaki Fizikai és Anyagtudományi Intézet">MFA</span>/Lendület Nanobioszenzorika Kutatócsoport; <span title="MTA Energiatudományi Kutatóközpont">MTA EK</span>/<span title="Műszaki Fizikai és Anyagtudományi Intézet">MFA</span>/Fotonika Laboratórium</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015596"><a href="/gui2/?type=authors&mode=browse&sel=10015596" target="_blank">Buzás Edit I ✉ (<span class="authorship-author-name">Buzás Edit Irén</span> <span class="authorAux-mtmt"> Immunbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3254659" target="_blank">Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">7</span> <span class="journal-issue">1</span> <span class="page"> Paper 8202. 16 p. </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-017-08392-1" target="_blank" href="https://doi.org/10.1038/s41598-017-08392-1"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="60347" target="_blank" href="http://real.mtak.hu/60347"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="5448" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/5448"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" 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class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 151</span> | Független: 134 | Függő: 17 | Nem jelölt: 0 | WoS jelölt: 136 | Scopus jelölt:&nbsp;135 | WoS/Scopus jelölt:&nbsp;139 | DOI jelölt:&nbsp;139 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3254659&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 15 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3254659</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3254659</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian Scientific Research Fund(11958) Támogató: OTKA, (FP7-PEOPLE-2011-ITN-PITN-GA-2011-289033 DYNANO), (PD112085), (PD104369), (NVKP_16-1-2016-0007) Támogató: NKFIH, National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH, (OTKA PD 109051), (120237) Támogató: OTKA, Hungarian Scientific Research Fund(11958) Támogató: OTKA </div> <div class="lastModified">Utolsó módosítás: 2026.02.05. 09:43 Bolgár Andrea (MFA admin 4) </div> <div class="lockedBy">Központi kezelésű 2026.01.21. 14:12 Mikola Katalin (MTMT 3, admin) </div> </div></div>