https://m2.mtmt.hu/ hun 2026-07-26 16:53 JournalArticle 32546517 ADMIN_APPROVED true Funding Agency and Grant Number: Hungarian Academy of Sciences, Momentum Grant [LP2014-7/2014]; Hungarian Academy of Sciences, Premium Postdoc Grant [2019-436]; Hungarian Academy of Sciences, Young Researcher Fellowships; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [OTKA K128262, OTKA K124862, FIEK_16-1-2016-0005]; Hungarian Ministry For National Economy [VEKOP-2.3.3-15-2017-0014]; MedInProt, Protein Science Research Synergy IV Program Grant; Adhoc Program Grant; USC Gynecology Oncology Research Fund Funding text: This research was funded by the Hungarian Academy of Sciences, Momentum Grant No LP2014-7/2014, Premium Postdoc_2019-436 Grant and Young Researcher Fellowships; the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the OTKA K128262, OTKA K124862 and FIEK_16-1-2016-0005 funding schemes; Hungarian Ministry For National Economy, Grant No VEKOP-2.3.3-15-2017-0014; MedInProt, Protein Science Research Synergy IV and Adhoc Program Grants; and the USC Gynecology Oncology Research Fund. 0 false 2026-05-21T11:04:42.476+0000 2026-01-13T09:29:00.162+0000 2021-12-21T09:47:21.355+0000 true 10035718 Sonnevend Kinga /api/admin/10035718 Admin Sonnevend Kinga (SE_AOK_Adm5_Élet_kutcsop, admin) true 10035718 2026-02-06T07:38:31.257+0000 2026-02-06T07:38:31.257+0000 2026-01-13T09:29:00.711+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin Csajbók Edit (SE_KK_Admin5_CSE, admin) true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Szabolcsi, Zoltan true true /api/journal/10056704 REVIEWED BIOMEDICINES 2227-9059 true false 10056704 false 10056704 true 2227-9059 Journal FOREIGN 9 12 1935 1935 21 2021 Gestational trophoblastic diseases (GTDs) have not been investigated for their epigenetic marks and consequent transcriptomic changes. Here, we analyzed genome-wide DNA methylation and transcriptome data to reveal the epigenetic basis of disease pathways that may lead to benign or malignant GTDs. RNA-Seq, mRNA microarray, and Human Methylation 450 BeadChip data from complete moles and choriocarcinoma cells were bioinformatically analyzed. Paraffin-embedded tissues from complete moles and control placentas were used for tissue microarray construction, DNMT3B immunostaining and immunoscoring. We found that DNA methylation increases with disease severity in GTDs. Differentially expressed genes are mainly upregulated in moles while predominantly downregulated in choriocarcinoma. DNA methylation principally influences the gene expression of villous trophoblast differentiation-related or predominantly placenta-expressed genes in moles and choriocarcinoma cells. Affected genes in these subsets shared focal adhesion and actin cytoskeleton pathways in moles and choriocarcinoma. In moles, cell cycle and differentiation regulatory pathways, essential for trophoblast/placental development, were enriched. In choriocarcinoma cells, hormone biosynthetic, extracellular matrix-related, hypoxic gene regulatory, and differentiation-related signaling pathways were enriched. In moles, we found slight upregulation of DNMT3B protein, a developmentally important de novo DNA methylase, which is strongly overexpressed in choriocarcinoma cells that may partly be responsible for the large DNA methylation differences. Our findings provide new insights into the shared and disparate molecular pathways of disease in GTDs and may help in designing new diagnostic and therapeutic tools. 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(HRN TTK / MÉI) 2 0.059 true false false Author 10055081 /api/author/10055081 Demeter Amanda (Biológia) Demeter Amanda true 10055081 true Demeter Amanda true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715716 /api/authorship/99715716 Kiraly, Peter* [Király, Péter (Fizikai-kémia), szerző] 3 0.059 true false false Author 10084062 /api/author/10084062 Király Péter (Fizikai-kémia) Király Péter true true Kiraly Peter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715717 /api/authorship/99715717 Balogh, Andrea [Balogh, Andrea (Immunológia), szerző] 4 0.05882353 false false false Author 10019319 /api/author/10019319 Balogh Andrea (Immunológia) Balogh Andrea true 10019319 true Balogh Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715718 /api/authorship/99715718 Wilson, Melissa L. 5 0.05882353 false false false Wilson Melissa L. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715719 /api/authorship/99715719 King, Jennifer R. 6 0.05882353 false false false King Jennifer R. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715720 /api/authorship/99715720 Hetey, Szabolcs 7 0.05882353 false false false Hetey Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715721 /api/authorship/99715721 Gelencser, Zsolt [Gelencsér, Zsolt (bioinformatika), szerző] Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI) 8 0.059 false false false Author 10029869 /api/author/10029869 Gelencsér Zsolt (bioinformatika) Gelencsér Zsolt true 10029869 true Gelencser Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715722 /api/authorship/99715722 Matsuo, Koji 9 0.05882353 false false false Matsuo Koji true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715723 /api/authorship/99715723 Hargitai, Beata [Hargitai, Beáta (Patológia), szerző] 10 0.05882353 false false false Author 10032563 /api/author/10032563 Hargitai Beáta (Patológia) Hargitai Beáta true 10032563 true Hargitai Beata true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715724 /api/authorship/99715724 Mhawech-Fauceglia, Paulette 11 0.05882353 false false false Mhawech-Fauceglia Paulette true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715725 /api/authorship/99715725 Hupuczi, Petronella [Hupuczi, Petronella (Aneszteziológia é...), szerző] Aneszteziológiai és Intenzív Terápiás Klinika (SE / AOK / K) 12 0.05882353 false false false Author 10012513 /api/author/10012513 Hupuczi Petronella (Aneszteziológia és intenzív terápia) Hupuczi Petronella true 10012513 true Hupuczi Petronella true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715726 /api/authorship/99715726 Szilagyi, Andras [Szilágyi, András (Bioinformatika), szerző] Enzimológiai Intézet (TTK); Lendület Reprodukció Rendszerbiológiája Kutatóc... (HRN TTK / MÉI) 13 0.059 false false false Author 10010376 /api/author/10010376 Szilágyi András (Bioinformatika) Szilágyi András true 10010376 true Szilagyi Andras true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715727 /api/authorship/99715727 Papp, Zoltan [Papp, Zoltán (Szülészet-nőgyógy...), szerző] Szülészeti és Nőgyógyászati Klinika (SE / AOK / K) 14 0.059 false false false Author 1373182 /api/author/1373182 Papp Zoltán (Szülészet-nőgyógyászat, klinikai genetika) Papp Zoltán true 1373182 true Papp Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715728 /api/authorship/99715728 Roman, Lynda D. 15 0.05882353 false false false Roman Lynda D. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715729 /api/authorship/99715729 Cortessis, Victoria K. 16 0.05882353 false false false Cortessis Victoria K. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99715730 /api/authorship/99715730 Than, Nandor Gabor ✉ [Than, Nándor Gábor (Rendszerbiológia), szerző] Enzimológiai Intézet (TTK); I. 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(2021) BIOMEDICINES 2227-9059 9 12<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Szabolcsi Zoltan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055081"><a href="/gui2/?type=authors&mode=browse&sel=10055081" target="_blank">Demeter Amanda^* (<span class="authorship-author-name">Demeter Amanda</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084062"><a href="/gui2/?type=authors&mode=browse&sel=10084062" target="_blank">Kiraly Peter^* (<span class="authorship-author-name">Király Péter</span> <span class="authorAux-mtmt"> Fizikai-kémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019319"><a href="/gui2/?type=authors&mode=browse&sel=10019319" target="_blank">Balogh Andrea (<span class="authorship-author-name">Balogh Andrea</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wilson Melissa L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >King Jennifer R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hetey Szabolcs </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029869"><a href="/gui2/?type=authors&mode=browse&sel=10029869" target="_blank">Gelencser Zsolt (<span class="authorship-author-name">Gelencsér Zsolt</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matsuo Koji </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032563"><a href="/gui2/?type=authors&mode=browse&sel=10032563" target="_blank">Hargitai Beata (<span class="authorship-author-name">Hargitai Beáta</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mhawech-Fauceglia Paulette </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012513"><a href="/gui2/?type=authors&mode=browse&sel=10012513" target="_blank">Hupuczi Petronella (<span class="authorship-author-name">Hupuczi Petronella</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Aneszteziológiai és Intenzív Terápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010376"><a href="/gui2/?type=authors&mode=browse&sel=10010376" target="_blank">Szilagyi Andras (<span class="authorship-author-name">Szilágyi András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1373182"><a href="/gui2/?type=authors&mode=browse&sel=1373182" target="_blank">Papp Zoltan (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roman Lynda D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cortessis Victoria K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than Nandor Gabor ✉ (<span class="authorship-author-name">Than Nándor Gábor</span> <span class="authorAux-mtmt"> Rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Lendület Reprodukció Rendszerbiológiája Kutatócsoport Enzim_416</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32546517" target="_blank">Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease</a></div> <div> <span class="journal-title">BIOMEDICINES</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2227-9059">2227-9059</a>)</span>: <span class="journal-volume">9</span> <span class="journal-issue">12</span> <span class="page"> Paper 1935. 21 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/biomedicines9121935" target="_blank" href="https://doi.org/10.3390/biomedicines9121935"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000736261600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000736261600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85121436375" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85121436375"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34944751" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34944751&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 13 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32546517&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32546517</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (LP2014-7/2014,), (K128262), (K124862), (FIEK_16-1-2016-0005), (VEKOP-2.3.3-15-2017-0014) </div> <div class="lastModified">Utolsó módosítás: 2026.01.13. 10:29 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian Academy of Sciences, Momentum Grant [LP2014-7/2014]; Hungarian Academy of Sciences, Premium Postdoc Grant [2019-436]; Hungarian Academy of Sciences, Young Researcher Fellowships; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [OTKA K128262, OTKA K124862, FIEK_16-1-2016-0005]; Hungarian Minis...</pre> </div></div>