https://m2.mtmt.hu/ eng 2026-08-25 11:48 JournalArticle 32529759 APPROVED true Department of Neuroscience, Columbia University, New York, NY, United States Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States Bioengineering Department, Imperial College London, London, United Kingdom Sainsbury Wellcome Centre, University College London, London, United Kingdom Institute of Experimental Medicine, Budapest, Hungary The Kavli Institute for Brain Science, Columbia University, New York, NY, United States Export Date: 13 August 2025; Cited By: 64; Correspondence Address: T. Geiller; Department of Neuroscience, Columbia University, New York, United States; email: tcg2117@columbia.edu; A. Losonczy; Department of Neuroscience, Columbia University, New York, United States; email: al2856@columbia.edu; CODEN: NATUA 0 false 2026-06-22T08:40:06.140+0000 2026-05-30T08:53:23.405+0000 2021-12-09T10:46:28.098+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-05-30T08:53:23.590+0000 2026-05-30T08:53:23.590+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Geiller, Tristan Local circuit amplification of spatial selectivity in the hippocampus. true true /api/journal/3308 REVIEWED true false 3308 false 3308 true 0028-0836 1476-4687 Journal FOREIGN 601 7891 105 109 105 5 2022 Local circuit architecture facilitates the emergence of feature selectivity in the cerebral cortex1. In the hippocampus, it remains unknown whether local computations supported by specific connectivity motifs2 regulate the spatial receptive fields of pyramidal cells3. Here we developed an in vivo electroporation method for monosynaptic retrograde tracing4 and optogenetics manipulation at single-cell resolution to interrogate the dynamic interaction of place cells with their microcircuitry during navigation. We found a local circuit mechanism in CA1 whereby the spatial tuning of an individual place cell can propagate to a functionally recurrent subnetwork5 to which it belongs. The emergence of place fields in individual neurons led to the development of inverse selectivity in a subset of their presynaptic interneurons, and recruited functionally coupled place cells at that location. Thus, the spatial selectivity of single CA1 neurons is amplified through local circuit plasticity to enable effective multi-neuronal representations that can flexibly scale environmental features locally without degrading the feedforward input structure. Funding 2025813 /api/funding/2025813 false true Funding 2025814 /api/funding/2025814 false true Funding 2025815 /api/funding/2025815 false true Funding 2025816 /api/funding/2025816 false true Funding 2025817 /api/funding/2025817 false true Funding 2025818 /api/funding/2025818 false true Funding 2025819 /api/funding/2025819 false true Funding 2025820 /api/funding/2025820 false true Funding 2025821 /api/funding/2025821 false true Funding 2025822 /api/funding/2025822 false true Funding 2025823 /api/funding/2025823 false true Funding 2025824 /api/funding/2025824 false true Funding 2025825 /api/funding/2025825 false true Funding 2025826 /api/funding/2025826 false true Funding 2025827 /api/funding/2025827 false true Funding 2025828 /api/funding/2025828 false true Funding 2025829 /api/funding/2025829 false true true true 2021 true true true false true false GOLD 2026-06-22 true https://real.mtak.hu/160663 81 0 81 67 3 81 81 79 74 81 81 67 67 67 14 0 81 67 81 67 0 3 3 Folyóiratcikk Journal Article 24 80 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 12 11 12 11 2023 0 22 20 22 20 2024 0 19 15 19 15 2025 0 22 15 22 15 2026 0 6 6 6 6 D1 A false 10012926 false false false 2022-03-09T10:46:34.323+0000 Kísérleti Orvostudományi Kutatóintézet; Neuronhálózat és Dendritikus Aktivitás Kutatócs... 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Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true MtaRating 11551101 /api/mtarating/11551101 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi false true MtaRating 519065 /api/mtarating/519065 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19065 true SjrRating 11272454 /api/sjrrating/11272454 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/32529759 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Geiller Tristan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sadeh Sadra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rolotti Sebastian V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Blockus Heike </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vancura Bert </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Negrean Adrian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Murray Andrew J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012926"><a href="/gui2/?type=authors&mode=browse&sel=10012926" target="_blank">Rózsa Balázs (<span class="authorship-author-name">Rózsa J. Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Polleux Franck </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Clopath Claudia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Losonczy Attila ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32529759" target="_blank">Local circuit amplification of spatial selectivity in the hippocampus.</a></div> <div> <span class="journal-title">NATURE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-0836">0028-0836</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-4687">1476-4687</a>)</span>: <span class="journal-volume">601</span> <span class="journal-issue">7891</span> <span class="page"> pp 105-109 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41586-021-04169-9" target="_blank" href="https://doi.org/10.1038/s41586-021-04169-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000724666000006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000724666000006"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="160663" target="_blank" href="https://real.mtak.hu/160663"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85120583459" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85120583459"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34853473" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34853473&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 81</span> | Independent citation: 67 | Self citation: 14 | Unknown citation: 0 | Number of citations in WoS: 79 | Number of citations in Scopus:&nbsp;74 | WoS/Scopus assigned:&nbsp;81 | Number of citations with DOI:&nbsp;81 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32529759&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32529759</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Institutes of Health NIH(F30MH125628), National Institutes of Health NIH(T32GN007367), National Institute of Mental Health, NIMH(1R01MH124047), National Institute of Mental Health, NIMH(1R01MH124867), National Institute of Neurological Disorders and Stroke(NINDS 1U01NS115530), National Institute of Neurological Disorders and Stroke NINDS(NINDS 1U19NS104590), Simons Foundation(564408), Wellcome Trust, WT(090843/F/09/Z), Wellcome Trust, WT(F31MH117892), Wellcome Trust, WT(K99NS115984-01), Wellcome Trust, WT(R01NS067557), Wellcome Trust, WT(R21NS109753-442 01A1), Engineering and Physical Sciences Research Council, EPSRC(1S10OD023587-01), Engineering and Physical Sciences Research Council, EPSRC(EP/R035806/1), Biotechnology and Biological Sciences Research Council(BBSRC 200790/Z/16/Z), Biotechnology and Biological Sciences Research Council(BBSRC BB/N019008/1), Biotechnology and Biological Sciences Research Council(BBSRC BB/N013956/1) </div> <div class="lastModified">Last Modified: 2026.05.30. 10:53 Évi Nemec (MTMT Központi 3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Neuroscience, Columbia University, New York, NY, United States Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States Bioengineering Department, Imperial College London, London, United Kingdom Sainsbury Wellcome Centre, University College London, London, United Ki...</pre> </div></div>