https://m2.mtmt.hu/ eng 2026-10-24 05:27 JournalArticle 32528725 VALIDATED true Megosztott utolsó szerzőség 0 false 2026-10-21T23:55:42.429+0000 2023-01-07T03:32:00.674+0000 2021-12-08T13:29:59.494+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-10-13T10:03:34.436+0000 2026-10-13T10:03:34.436+0000 2021-12-11T10:04:57.921+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080106 /api/admin/10080106 Király Magdolna true true 2024-10-17T16:46:05.635+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Xu, Lu Leptin coordinates efferent sympathetic outflow to the white adipose tissue through the midbrain centrally-projecting Edinger-Westphal nucleus in male rats. true true /api/journal/3361 REVIEWED true false 3361 false 3361 true 0028-3908 1873-7064 Journal FOREIGN 205 108898 108898 15 2022 The centrally-projecting Edinger-Westphal nucleus (EWcp) hosts a large population of neurons expressing urocortin 1 (Ucn1) and about half of these neurons also express the leptin receptor (LepRb). Previously, we have shown that the peripheral adiposity hormone leptin signaling energy surfeit modulates EWcp neurons' activity. Here, we hypothesized that Ucn1/LepRb neurons in the EWcp would act as a crucial neuronal node in the brain-white adipose tissue (WAT) axis modulating efferent sympathetic outflow to the WAT. We showed that leptin bound to neurons of the EWcp stimulated STAT3 phosphorylation, and increased Ucn1-production in a time-dependent manner. Besides, retrograde transneuronal tract-tracing using pseudorabies virus (PRV) identified EWcp Ucn1 neurons connected to WAT. Interestingly, reducing EWcp Ucn1 contents by ablating EWcp LepRb-positive neurons with leptin-saporin, did not affect food intake and body weight gain, but substantially (+26%) increased WAT weight accompanied by a higher plasma leptin level and changed plasma lipid profile. We also found that ablation of EWcp Ucn1/LepRb neurons resulted in lower respiratory quotient and oxygen consumption one week after surgery, but was comparable to sham values after 3 and 5 weeks of surgery. Taken together, we report that EWcp/LepRb/Ucn1 neurons not only respond to leptin signaling but also control WAT size and fat metabolism without altering food intake. These data suggest the existence of a EWcp-WAT circuitry allowing an organism to recruit fuels without being able to eat in situations such as the fight-or-flight response. Funding 2006887 /api/funding/2006887 false true Funding 2006888 /api/funding/2006888 false true Funding 2006889 /api/funding/2006889 false true Funding 2006890 /api/funding/2006890 false true true true 2021 true true true false true false GOLD 2026-10-22 true https://real.mtak.hu/160683 9 0 9 6 3 9 9 8 9 9 9 6 6 6 3 0 9 6 9 6 0 24 24 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 3 2 3 2 2023 0 2 1 2 1 2024 0 1 0 1 0 2025 0 3 3 3 3 Q1 false 10016413,10016935 false false false 2021-12-10T10:04:57.651+0000 Anatómiai Intézet (PTE / ÁOK); Molekuláris Neuroendokrinológiai Kutatócsoport (HRN KOKI); Neuroimmunológiai Kutatócsoport (HRN KOKI); Transzlációs Medicina Intézet (PTE / ÁOK) 7 30 4 10 0 true 10080106 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 99623504 /api/authorship/99623504 1 0.1 true false false Xu Lu true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623505 /api/authorship/99623505 2 0.1 false false false Author 10040442 /api/author/10040442 Füredi Nóra true 10040442 true Füredi Nóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623506 /api/authorship/99623506 3 0.1 false false false Lutter Christoph true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623507 /api/authorship/99623507 4 0.1 false false false Geenen Bram true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623508 /api/authorship/99623508 5 0.1 false false false Author 10016935 /api/author/10016935 Pétervári Erika true 10016935 true Pétervári Erika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623509 /api/authorship/99623509 6 0.1 false false false Author 10016413 /api/author/10016413 Balaskó Márta true 10016413 true Balaskó Márta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623510 /api/authorship/99623510 7 0.1 false false false Author 10012934 /api/author/10012934 Dénes Ádám true 10012934 true Dénes Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623511 /api/authorship/99623511 8 0.1 false false false Author 10009124 /api/author/10009124 Kovács Krisztina true 10009124 true Kovács Krisztina J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623512 /api/authorship/99623512 9 0.1 false true true Author 10016463 /api/author/10016463 Gaszner Balázs true 10016463 true Gaszner Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99623513 /api/authorship/99623513 10 0.1 false true true Author 10077794 /api/author/10077794 Kozicz Tamás true true Kozicz Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20274279 /api/publicationidentifier/20274279 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY IDENTICAL 10.1016/j.neuropharm.2021.108898 https://doi.org/10.1016/j.neuropharm.2021.108898 false true PublicationIdentifier 20968981 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/api/keyword/1035045 true 1035045 true Keyword 1039725 /api/keyword/1039725 true 1039725 true Keyword 1082508 /api/keyword/1082508 true 1082508 true Keyword 1802749 /api/keyword/1802749 true true SjrRating 11321415 /api/sjrrating/11321415 42 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3004 /api/classificationexternal/3004 true 3004 true Q1 DIRECT true true /api/publication/32528725 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Xu Lu </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040442"><a href="/gui2/?type=authors&mode=browse&sel=10040442" target="_blank">Füredi Nóra (<span class="authorship-author-name">Füredi Nóra</span> <span class="authorAux-mtmt"> Anyagcsere, idegtudomány, stressz, depresszió</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Anatomy; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lutter Christoph </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Geenen Bram </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016935"><a href="/gui2/?type=authors&mode=browse&sel=10016935" target="_blank">Pétervári Erika (<span class="authorship-author-name">Pétervári Erika</span> <span class="authorAux-mtmt"> Az energia-háztartás szabályozása és mediátor-h...</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016413"><a href="/gui2/?type=authors&mode=browse&sel=10016413" target="_blank">Balaskó Márta (<span class="authorship-author-name">Balaskó Márta</span> <span class="authorAux-mtmt"> Az energia-háztartás szabályozásának életkor- é...</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012934"><a href="/gui2/?type=authors&mode=browse&sel=10012934" target="_blank">Dénes Ádám (<span class="authorship-author-name">Dénes Ádám</span> <span class="authorAux-mtmt"> Neurobiológia, neuroimmunológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Neuroimmunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009124"><a href="/gui2/?type=authors&mode=browse&sel=10009124" target="_blank">Kovács Krisztina J (<span class="authorship-author-name">Kovács Krisztina</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Neuroendocrinology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016463"><a href="/gui2/?type=authors&mode=browse&sel=10016463" target="_blank">Gaszner Balázs<sup>**</sup> ✉ (<span class="authorship-author-name">Gaszner Balázs</span> <span class="authorAux-mtmt"> Neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Anatomy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077794"><a href="/gui2/?type=authors&mode=browse&sel=10077794" target="_blank">Kozicz Tamás ✉ (<span class="authorship-author-name">Kozicz Tamás</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32528725" target="_blank">Leptin coordinates efferent sympathetic outflow to the white adipose tissue through the midbrain centrally-projecting Edinger-Westphal nucleus in male rats.</a></div> <div> <span class="journal-title">NEUROPHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-3908">0028-3908</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-7064">1873-7064</a>)</span>: <span class="journal-volume">205</span> <span class="page"> Paper 108898. 15 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1016/j.neuropharm.2021.108898" target="_blank" href="https://doi.org/10.1016/j.neuropharm.2021.108898"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000786657800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000786657800001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="160683" target="_blank" href="https://real.mtak.hu/160683"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85120550924" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85120550924"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34861283" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34861283&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.sciencedirect.com/science/article/pii/S002839082100455X" target="_blank" href="https://www.sciencedirect.com/science/article/pii/S002839082100455X"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 9</span> | Independent citation: 6 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 8 | Number of citations in Scopus:&nbsp;9 | WoS/Scopus assigned:&nbsp;9 | Number of citations with DOI:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32528725&sort=publishedYear,desc&sort=title"> Number of cited publications: 24 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32528725</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (GINOP- 2.3.2-15- 2016-00050 “PEPSYS”), Thematic Excellence Program (Semmelweis University)(2020-4.1.1.-TKP2020) Funder: Ministry for Innovation and Technology, (TKP2020-IKA-08) Funder: NKFIA, (20-4-II-PTE-547) Funder: New National Excellence Programme </div> <div class="lastModified">Last Modified: 2023.01.07. 04:32 Róbert Milánkovics (PTE ÁOK admin 4) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:46 Gusztáv Ladányi (MTMT API user, admin) Magdolna Király (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Megosztott utolsó szerzőség</pre> </div></div>