Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes

https://m2.mtmt.hu/ eng 2026-10-23 03:48 JournalArticle 32522070 APPROVED true Institute of Enzymology, ELKH Research Centre for Natural Sciences, Center of Excellence by Hungarian Academy of Sciences, Budapest, Hungary Doctoral School of Molecular Medicine, Semmelweis University, Budapest, Hungary Drug Research Center, Balatonfüred, Hungary Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Veszprém, Hungary CellPharma Kft, Budapest, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary Cited By :4 Export Date: 12 January 2024 CODEN: POLNC Correspondence Address: Szabó, E.; Institute of Enzymology, Hungary; email: szabo.edit@ttk.hu Correspondence Address: Várady, G.; Institute of Enzymology, Hungary; email: varady.gyorgy@ttk.hu 0 false 2026-10-21T23:36:42.642+0000 2025-02-25T23:05:15.566+0000 2021-12-03T09:49:55.801+0000 true 10040526 Szabó Edit Zsuzsanna /api/author/10040526 Author Edit Zsuzsanna Szabó (biológus) true 10040526 2025-03-12T14:26:46.595+0000 2025-03-12T14:26:46.595+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Szabó, Edit Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes true true /api/journal/10007440 REVIEWED PLOS ONE 1932-6203 true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 16 12 e0260957 e0260957 9 2021 Type 2 diabetes mellitus (T2DM) is a complex metabolic disease and variations in multispecific membrane transporter functions may affect T2DM development, complications or treatment. In this work we have analyzed the potential effects of a major polymorphism, the Q141K variant of the ABCG2 transporter in T2DM. The ABCG2 protein is a multispecific xeno- and endobiotic transporter, affecting drug metabolism and playing a key role in uric acid extrusion. The ABCG2-Q141K variant, with reduced expression level and function, is present in 15–35% of individuals, depending on the genetic background of the population, and has been shown to significantly affect gout development. Several other diseases, including hypertension, chronic renal failure, and T2DM have also been reported to be associated with high serum uric acid levels, suggesting that ABCG2 may also play a role in these conditions. In this work we have compared relatively small cohorts (n = 203) of T2DM patients (n = 99) and healthy (n = 104) individuals regarding the major laboratory indicators of T2DM and determined the presence of the SNP rs2231142 (C421A), resulting the ABCG2-Q141K protein variant. We found significantly higher blood glucose and HbA1c levels in the T2DM patients carrying the ABCG2-Q141K variant. These findings may emphasize the potential metabolic role of ABCG2 in T2DM and indicate that further research should explore how prevention and treatment of this disease may be affected by the frequent polymorphism of ABCG2. 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Doktori Iskola (SE); Enzimológiai Intézet (TTK) 7 45 3 9 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 99587318 /api/authorship/99587318 Szabó, Edit ✉ [Szabó, Edit Zsuzsanna (biológus), author] Institute of Enzymology (RCNS) 1 0.111 true false true Author 10040526 /api/author/10040526 Edit Zsuzsanna Szabó (biológus) Szabó Edit Zsuzsanna true 10040526 true Szabó Edit true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99587319 /api/authorship/99587319 Kulin, Anna [Kulin, Anna (biológus), author] Institute of Enzymology (RCNS); School of PhD Studies (SU) 2 0.11111111 false false false Author 10071451 /api/author/10071451 Anna Kulin (biológus) Kulin Anna true true Kulin Anna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99587320 /api/authorship/99587320 Mózner, Orsolya [Mózner, Orsolya (biomembrán), author] Institute of Enzymology (RCNS); School of PhD Studies (SU) 3 0.111 false false false Author 10073889 /api/author/10073889 Orsolya Mózner (biomembrán) Mózner Orsolya true true Mózner Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99587321 /api/authorship/99587321 Korányi, László [Korányi, László (Orvostudomány), author] 4 0.11111111 false false false Author 10008869 /api/author/10008869 László Korányi (Orvostudomány) Korányi László true 10008869 true Korányi László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99587322 /api/authorship/99587322 Literáti-Nagy, Botond [Literáti-Nagy, Botond (belgyógyászat), author] 5 0.11111111 false false false Author 10040919 /api/author/10040919 Botond Literáti-Nagy (belgyógyászat) Literáti-Nagy Botond true 10040919 true Literáti-Nagy Botond true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99587323 /api/authorship/99587323 Vitai, Márta 6 0.11111111 false false false Vitai Márta true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99587324 /api/authorship/99587324 Cserepes, Judit 7 0.11111111 false false false Cserepes Judit true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 99587325 /api/authorship/99587325 Sarkadi, Balázs [Sarkadi, Balázs (biofizika), author] Institute of Enzymology (RCNS); 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(2021) PLOS ONE 1932-6203 16 12<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10040526"><a href="/gui2/?type=authors&mode=browse&sel=10040526" target="_blank">Szabó Edit ✉ (<span class="authorship-author-name">Szabó Edit Zsuzsanna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> ;    <span class="author-name" mtid="10071451"><a href="/gui2/?type=authors&mode=browse&sel=10071451" target="_blank">Kulin Anna (<span class="authorship-author-name">Kulin Anna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;    <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;    <span class="author-name" mtid="10008869"><a href="/gui2/?type=authors&mode=browse&sel=10008869" target="_blank">Korányi László (<span class="authorship-author-name">Korányi László</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> ;    <span class="author-name" mtid="10040919"><a href="/gui2/?type=authors&mode=browse&sel=10040919" target="_blank">Literáti-Nagy Botond (<span class="authorship-author-name">Literáti-Nagy Botond</span> <span class="authorAux-mtmt"> belgyógyászat</span>) </a> </span> ;    <span class="author-name" >Vitai Márta </span> ;    <span class="author-name" >Cserepes Judit </span> ;    <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Departmnet of Biophysics and Radiation Biology</span> ;    <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady György ✉ (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32522070" target="_blank">Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">12</span> <span class="page"> Paper e0260957. 9 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0260957" target="_blank" href="https://doi.org/10.1371/journal.pone.0260957"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000735299000155" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000735299000155"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85120621886" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85120621886"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34855903" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34855903&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary   Rank: Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]   A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]   A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]   B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 11</span> | Independent citation: 8 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus: 11 | WoS/Scopus assigned: 11 | Number of citations with DOI: 11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32522070&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32522070</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKFIH K-128011), (FIEK_16-1-2016-0005), (VEKOP-2.1.1-15-2016-00117) </div> <div class="lastModified">Last Modified: 2025.02.26. 00:05 Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Enzymology, ELKH Research Centre for Natural Sciences, Center of Excellence by Hungarian Academy of Sciences, Budapest, Hungary Doctoral School of Molecular Medicine, Semmelweis University, Budapest, Hungary Drug Research Center, Balatonfüred, Hungary Research Institute of Biomolecular and Chemical Engineering,...</pre> </div></div>