European Regional Development Fund(GINOP-2.3.3-15-2016-00021) Támogató: GINOP
(GINOP-2.3.4-15-2020-00008)
Szakterületek:
Orvos- és egészségtudomány
BGP-15 is a Hungarian-developed drug candidate with numerous beneficial effects. Its
potential anti-inflammatory effect is a common assumption, but it has not been investigated
in topical formulations yet. The aim of our study was to formulate 10% BGP-15 creams
with different penetration enhancers to ensure good drug delivery, improve bioavailability
of the drug and investigate the potential anti-inflammatory effect of BGP-15 creams
in vivo. Since the exact mechanism of the effect is still unknown, the antioxidant
effect (tested with UVB radiation) and the ability of BGP-15 to decrease macrophage
activation were evaluated. Biocompatibility investigations were carried out on HaCaT
cells to make sure that the formulations and the selected excipients can be safely
used. Dosage form studies were also completed with texture analysis and in vitro release
with Franz diffusion chamber apparatus. Our results show that the ointments were able
to reduce the extent of local inflammation in mice, but the exact mechanism of the
effect remains unknown since BGP-15 did not show any antioxidant effect, nor was it
able to decrease LPS-induced macrophage activation. Our results support the hypothesis
that BGP-15 has a potential anti-inflammatory effect, even if it is topically applied,
but the mechanism of the effect remains unclear and requires further pharmacological
studies.
