https://m2.mtmt.hu/ eng 2026-10-25 03:53 JournalArticle 32501295 VALIDATED true 0 false 2026-10-21T23:03:21.014+0000 2026-05-05T12:32:38.796+0000 2021-11-19T14:17:49.759+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-05-05T12:32:39.132+0000 2026-05-05T12:32:39.132+0000 2023-09-02T13:43:48.688+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-02-01T13:22:05.795+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Bruzsik, Biborka Neurochemically distinct populations of the bed nucleus of stria terminalis modulate innate fear response to weak threat evoked by predator odor stimuli true true /api/journal/10045166 REVIEWED true false 10045166 false 10045166 true 2352-2895 Journal FOREIGN 15 100415 100415 11 2021 Anxiety and trauma-related disorders are characterized by significant alterations in threat detection, resulting in inadequate fear responses evoked by weak threats or safety stimuli. Recent research pointed out the important role of the bed nucleus of stria terminalis (BNST) in threat anticipation and fear modulation under ambiguous threats, hence, exaggerated fear may be traced back to altered BNST function. To test this hypothesis, we chemogenetically inhibited specific BNST neuronal populations (corticotropin-releasing hormone - BNSTCRH and somatostatin - BNSTSST expressing neurons) in a predator odor-evoked innate fear paradigm. The rationale for this paradigm was threefold: (1) predatory cues are particularly strong danger signals for all vertebrate species evoking defensive responses on the flight-avoidance-freezing dimension (conservative mechanisms), (2) predator odor can be presented in a scalable manner (from weak to strong), and (3) higher-order processing of olfactory information including predatory odor stimuli is integrated by the BNST. Accordingly, we exposed adult male mice to low and high predatory threats presented by means of cat urine, or low- and high-dose of 2-methyl-2-thiazoline (2MT), a synthetic derivate of a fox anogenital product, which evoked low and high fear response, respectively. Then, we tested the impact of chemogenetic inhibition of BNSTCRH and BNSTSST neurons on innate fear responses using crh- and sst-ires-cre mouse lines. We observed that BNSTSST inhibition was effective only under low threat conditions, resulting in reduced avoidance and increased exploration of the odor source. In contrast, BNSTCRH inhibition had no impact on 2MT-evoked responses, but enhanced fear responses to cat odor, representing an even weaker threat stimulus. These findings support the notion that BNST is recruited by uncertain or remote, potential threats, and CRH and SST neurons orchestrate innate fear responses in complementary ways. Funding 2008065 /api/funding/2008065 false true Funding 2008066 /api/funding/2008066 false true Funding 2008067 /api/funding/2008067 false true Funding 2008068 /api/funding/2008068 false true Funding 2008069 /api/funding/2008069 false true Funding 2008070 /api/funding/2008070 false true true true 2021 true true true false true false GOLD 2026-10-22 true https://doi.org/10.1016/j.ynstr.2021.100415 31 0 27 21 8 27 27 31 24 31 27 25 21 25 6 0 31 25 27 21 0 3 3 Folyóiratcikk Journal Article 24 27 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 4 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 4 3 4 3 2023 0 10 8 10 8 2024 0 4 4 4 4 2025 0 8 6 8 6 2026 0 5 4 5 4 Q1 false 177,10030200,10012928 false false false 2021-11-22T08:04:41.113+0000 Doktori Iskola (SE); Magatartásélettan és Stressz Kutatócsoport (KOKI / MO); Szentágothai János Kutatóközpont (PTE); Transzlációs Magatartás Idegtudomány Kutatócsoport (HRN KOKI); Élettani Intézet (PTE / ÁOK) 8 25 5 9 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 99451775 /api/authorship/99451775 1 0.111 true false false Author 10054890 /api/author/10054890 Bruzsik Bíborka true 10054890 true Bruzsik Biborka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99451776 /api/authorship/99451776 2 0.111 false false false Author 10030200 /api/author/10030200 Bíró László true 10030200 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PersonAuthorship 99451781 /api/authorship/99451781 7 0.111 false false false Author 10066202 /api/author/10066202 Szocsics-Török Bibiána true true Török Bibiána true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99451782 /api/authorship/99451782 8 0.111 false true false Author 10012928 /api/author/10012928 Mikics Éva true 10012928 true Mikics Eva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99451783 /api/authorship/99451783 9 0.111 false true true Author 177 /api/author/177 Tóth Máté true 177 true Toth Mate true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20208134 /api/publicationidentifier/20208134 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.ynstr.2021.100415 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/api/classificationexternal/1303 true 1303 true Q1 DIRECT true true /api/publication/32501295 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10054890"><a href="/gui2/?type=authors&mode=browse&sel=10054890" target="_blank">Bruzsik Biborka (<span class="authorship-author-name">Bruzsik Bíborka</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030200"><a href="/gui2/?type=authors&mode=browse&sel=10030200" target="_blank">Biro Laszlo (<span class="authorship-author-name">Bíró László</span> <span class="authorAux-mtmt"> Magatartásélettan</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sarosdi Klara Rebeka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011471"><a href="/gui2/?type=authors&mode=browse&sel=10011471" target="_blank">Zelena Dora (<span class="authorship-author-name">Zelena Dóra</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute of Physiology; <span title="University of Pécs">UP</span>/Szentágothai Research Centre; <span title="Institute of Experimental Medicine">IEM</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040883"><a href="/gui2/?type=authors&mode=browse&sel=10040883" target="_blank">Sipos Eszter (<span class="authorship-author-name">Bodóné Sipos Eszter</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076338"><a href="/gui2/?type=authors&mode=browse&sel=10076338" target="_blank">Szebik Huba (<span class="authorship-author-name">Szebik Huba</span> <span class="authorAux-mtmt"> idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066202"><a href="/gui2/?type=authors&mode=browse&sel=10066202" target="_blank">Török Bibiána (<span class="authorship-author-name">Szocsics-Török Bibiána</span> <span class="authorAux-mtmt"> Biológus</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012928"><a href="/gui2/?type=authors&mode=browse&sel=10012928" target="_blank">Mikics Eva<sup>**</sup> (<span class="authorship-author-name">Mikics Éva</span> <span class="authorAux-mtmt"> Neuroendokrinológia, viselkedésbiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="177"><a href="/gui2/?type=authors&mode=browse&sel=177" target="_blank">Toth Mate ✉ (<span class="authorship-author-name">Tóth Máté</span> <span class="authorAux-mtmt"> Magatartástudomány</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Translational Behavioural Neuroscience Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32501295" target="_blank">Neurochemically distinct populations of the bed nucleus of stria terminalis modulate innate fear response to weak threat evoked by predator odor stimuli</a></div> <div> <span class="journal-title">NEUROBIOLOGY OF STRESS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2352-2895">2352-2895</a>)</span>: <span class="journal-volume">15</span> <span class="page"> Paper 100415. 11 p. </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.ynstr.2021.100415" target="_blank" href="https://doi.org/10.1016/j.ynstr.2021.100415"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000717674900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000717674900001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="140270" target="_blank" href="https://real.mtak.hu/140270"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85122679888" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85122679888"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34765699" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34765699&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Endocrine and Autonomic Systems&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physiology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 31</span> | Independent citation: 25 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 31 | Number of citations in Scopus:&nbsp;24 | WoS/Scopus assigned:&nbsp;31 | Number of citations with DOI:&nbsp;27 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32501295&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 32501295</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Research, Development and 41 Innovation Office Grants(FK129296), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (UNKP-18-3-III-SE-22), National Excellence Program of the Ministry for 44 Innovation and Technology(UNKP-19-2-I-ELTE-574), New National Excellence Program of the Ministry for 44 Innovation and Technology Grants(UNKP-20-5-SE), (UNKP-21-5-SE-13) </div> <div class="lastModified">Last Modified: 2026.05.05. 14:32 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2024.02.01. 14:22 Andrea Vándor (VA, admin) </div> </div></div>