https://m2.mtmt.hu/ hun 2026-06-25 01:37 BookChapter 3248732 VALIDATED true 0 2017-07-15T10:43:32.000+0000 false 3248732 2026-05-17T21:25:00.083+0000 2026-02-13T09:57:56.498+0000 2017-07-15T10:38:31.000+0000 true 10039656 Kmety Andrea /api/admin/10039656 Admin true 10039656 2026-02-13T09:57:56.218+0000 2017-07-15T10:43:32.000+0000 true 10039656 Kmety Andrea /api/admin/10039656 Admin true 10039656 2023-11-22T07:55:37.638+0000 true 10079265 Tomcsik Adrienn /api/admin/10079265 Admin true true false true 25 25 /api/publicationtype/25 PublicationType 2 true 25 BookChapter true 10000398 Chapter true 25 25 /api/publicationtype/25 PublicationType 2 true 25 BookChapter /api/subtype/10000398 Könyvfejezet SubType 220 true 10000398 true 1 /api/category/1 Category true 1 Érdi, P Connecting Epilepsy and Alzheimer’s Disease: Modeling of Normal and Pathological Rhythmicity and Synaptic Plasticity Related to Amyloidββ (Aββ) Effects 93 120 93 28 2017 This chapter is motivated by the hidden links between neurodegeneration due to Alzheimer’s disease and temporal lobe epileptic activity. The following argument is based on the multiple effects of $$\beta $$ -amyloid peptides (A $$\beta $$ ) forming these links potentially at molecular, cellular, synaptic, network, as well as system levels. To explore these links a computational framework was discussed, and two parts of the framework, i.e. pathological rhythm generation and altered bidirectional synaptic plasticity have been constructed and analyzed. By using a skeleton network model of the hippocampal rhythm generation it was demonstrated how A $$\beta $$ affects the ability of neurons in hippocampal networks to fire in unison at theta frequency resulting in reduced power of the theta rhythm. The dual qualitative effects of elevated A $$\beta $$ at the synaptic level, i.e. LTD facilitation and LTP impairment is studied by a modified calcium control hypothesis. The modification implemented the $$\beta $$ -amyloid effects on the bidirectional synaptic plasticity and explained well the experimental findings of decreased LTP and increased LTD. The analysis of a kinetic model taking into account the phosphorylation and dephosphorylation pathways associated with potentiation and depression of the AMPA receptor activity supported the biological plausibility of the modification. Such kinds of models offer an integrative perspective to organize scattered data obtained by methods of anatomy, electrophysiology, brain imaging, neurochemistry, behavioral studies, etc. into a coherent picture. 2017 910627 true true true false true false NONE 2026-05-17 false true 10039656 Kmety Andrea /api/admin/10039656 Admin true 10039656 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 8 8 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2017 0 1 0 1 0 false false false false 2017-07-15T10:43:32.000+0000 2017-07-15T10:43:30.000+0000 Elméleti idegtudomány és komplex rendszerek kut... (RMI / KTO) 3 17 1 5 0 true true 10002 English /api/language/10002 Angol Language true 2 false true 15258 true 10022 /api/country/10022 Country true 18 /api/city/15258 City true 10006686 true 1214228 /api/publicationidentifier/1214228 https://www.worldcat.org/search?q=isbn%3A9783319499598 9783319499598 PublicationIdentifier true 122 ISBN https://www.worldcat.org/search?q=isbn%3A@@@ /api/publicationsource/122 ISBN PlainSource true true 10002 /api/publicationsourcetype/10002 PublicationSourceType true false 122 true false /api/publication/3248731 true true 23 23 /api/publicationtype/23 PublicationType 3 true 23 Book Computational Neurology and Psychiatry 3248731 false true 3248731 true true false true true 10000201 Monograph true 23 23 /api/publicationtype/23 PublicationType 3 true 23 Book /api/subtype/10000201 Szakkönyv SubType 337 true 10000201 true Book 2017 true 1 /api/category/1 Category true 1 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 9193237 /api/authorship/9193237 1 0.2 true false Author 10002468 /api/author/10002468 Érdi Péter true 10002468 true Érdi P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 26609863 true PersonAuthorship 9193238 /api/authorship/9193238 2 0.2 false false Matsuzawa T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 26609862 true PersonAuthorship 9193239 /api/authorship/9193239 3 0.2 false false John T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 26609861 true PersonAuthorship 9193240 /api/authorship/9193240 4 0.2 false false Author 10012667 /api/author/10012667 Kiss Tamás true 10012667 true Kiss T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 26609860 true PersonAuthorship 9193241 /api/authorship/9193241 5 0.2 false true Author 10017158 /api/author/10017158 Zalányi László András true 10017158 true Zalányi L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 26609859 true PublicationIdentifier 1214229 /api/publicationidentifier/1214229 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1007/978-3-319-49959-8_5 https://doi.org/10.1007/978-3-319-49959-8_5 false 1612791 true PublicationIdentifier 20648623 /api/publicationidentifier/20648623 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000413619700005 https://www.webofscience.com/wos/woscc/full-record/000413619700005 true true /api/publication/3248732 <div class="BookChapter Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10002468"><a href="/gui2/?type=authors&mode=browse&sel=10002468" target="_blank">Érdi P (<span class="authorship-author-name">Érdi Péter</span> <span class="authorAux-mtmt"> Fizikai kémia, matematikai modellek, elméleti n...</span>) </a> </span> <span class="author-affil"><span title="MTA Wigner Fizikai Kutatóközpont">MTA Wigner</span>/<span title="Részecske- és Magfizikai Intézet">RMI</span>/<span title="Elméleti Fizikai Osztály">ELMO</span>/Elméleti idegtudomány és komplex rendszerek kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Matsuzawa T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >John T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012667"><a href="/gui2/?type=authors&mode=browse&sel=10012667" target="_blank">Kiss T (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> Elméleti idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Wigner Fizikai Kutatóközpont">MTA Wigner</span>/<span title="Részecske- és Magfizikai Intézet">RMI</span>/<span title="Elméleti Fizikai Osztály">ELMO</span>/Elméleti idegtudomány és komplex rendszerek kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017158"><a href="/gui2/?type=authors&mode=browse&sel=10017158" target="_blank">Zalányi L (<span class="authorship-author-name">Zalányi László András</span> <span class="authorAux-mtmt"> Fizika, Elméleti idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Wigner Fizikai Kutatóközpont">MTA Wigner</span>/<span title="Részecske- és Magfizikai Intézet">RMI</span>/<span title="Elméleti Fizikai Osztály">ELMO</span>/Elméleti idegtudomány és komplex rendszerek kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3248732" target="_blank">Connecting Epilepsy and Alzheimer’s Disease: Modeling of Normal and Pathological Rhythmicity and Synaptic Plasticity Related to Amyloidββ (Aββ) Effects</a></div> <div class="InBook"><div class="chapter-in">In:</div> <div class="authors"> <div class="autype autype-1"> <span class="author-name" mtid="10002468"><a href="/gui2/?type=authors&mode=browse&sel=10002468" target="_blank">Érdi P (<span class="authorship-author-name">Érdi Péter</span> <span class="authorAux-mtmt"> Fizikai kémia, matematikai modellek, elméleti n...</span>) </a> </span> <span class="author-affil"><span title="MTA Wigner Fizikai Kutatóközpont">MTA Wigner</span>/<span title="Részecske- és Magfizikai Intézet">RMI</span>/<span title="Elméleti Fizikai Osztály">ELMO</span>/Elméleti idegtudomány és komplex rendszerek kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sen Bhattacharya B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cochran AL </span> (szerk.) </div> </div> <div class="booktitle"><a href="/gui2/?mode=browse&params=publication;3248731" target="_blank">Computational Neurology and Psychiatry </a></div> <span class="publishedAt">Cham: <span class="publishers">Springer Netherlands</span>, <span class="page"> pp 93-120 </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/978-3-319-49959-8_5" target="_blank" href="https://doi.org/10.1007/978-3-319-49959-8_5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000413619700005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000413619700005"> WoS </a> </span> </span> <span class="bookchapter-ids">Befoglaló link(ek):</span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <span class="isbnOrIssn"> ISBN: </span> <a style="color:black" title="9783319499598" target="_blank" href="https://www.worldcat.org/search?q=isbn%3A9783319499598"> 9783319499598 </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3248732&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3248732</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="long-book-mtid">Befoglaló: 3248731</span> <span class="oldId">Régi azonosító: 3248732</span> | <span class="oldId">Befoglaló: 3248731</span> Forrás Idéző | <span class="type-subtype">Könyvrészlet ( Könyvfejezet ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Utolsó módosítás: 2026.02.13. 10:57 Szabó Emese (Wigner admin5) </div> </div> </div>