https://m2.mtmt.hu/ hun 2026-09-21 15:56 JournalArticle 32470555 VALIDATED true * Megosztott szerzőség 0 false 2026-08-31T09:19:05.074+0000 2023-09-02T13:43:14.751+0000 2021-10-28T11:09:45.128+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-08-27T10:34:35.679+0000 2023-09-02T13:43:15.060+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kaucsár, Tamás Divergent regulation of lncRNA expression by ischemia in adult and aging mice. true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 44 1 429 445 429 17 2022 Elderly patients have increased susceptibility to acute kidney injury (AKI). Long noncoding RNAs (lncRNA) are key regulators of cellular processes, and have been implicated in both aging and AKI. Our aim was to study the effects of aging and ischemia-reperfusion injury (IRI) on the renal expression of lncRNAs. Adult and old (10- and 26-30-month-old) C57BL/6 N mice were subjected to unilateral IRI followed by 7 days of reperfusion. Renal expression of 90 lncRNAs and mRNA expression of injury, regeneration, and fibrosis markers was measured by qPCR in the injured and contralateral control kidneys. Tubular injury, regeneration, and fibrosis were assessed by histology. Urinary lipocalin-2 excretion was increased in old mice prior to IRI, but plasma urea was similar. In the control kidneys of old mice tubular cell necrosis and apoptosis, mRNA expression of kidney injury molecule-1, fibronectin-1, p16, and p21 was elevated. IRI increased plasma urea concentration only in old mice, but injury, regeneration, and fibrosis scores and their mRNA markers were similar in both age groups. AK082072 and Y lncRNAs were upregulated, while H19 and RepA transcript were downregulated in the control kidneys of old mice. IRI upregulated Miat, Igf2as, SNHG5, SNHG6, RNCR3, Malat1, Air, Linc1633, and Neat1 v1, while downregulated Linc1242. LncRNAs H19, AK082072, RepA transcript, and Six3os were influenced by both aging and IRI. Our results indicate that both aging and IRI alter renal lncRNA expression suggesting that lncRNAs have a versatile and complex role in aging and kidney injury. An Ingenuity Pathway Analysis highlighted that the most downregulated H19 may be linked to aging/senescence through p53. Funding 2004975 /api/funding/2004975 false true Funding 2004976 /api/funding/2004976 false true Funding 2004977 /api/funding/2004977 false true Funding 2010856 /api/funding/2010856 false true Funding 2010857 /api/funding/2010857 false true Funding 2010858 /api/funding/2010858 false true Funding 2010859 /api/funding/2010859 false true true 2021 true true true false true false GOLD 2026-08-31 true https://doi.org/10.1007/s11357-021-00460-9 12 0 12 12 0 12 12 12 12 12 12 12 12 12 0 0 12 12 12 12 0 5 5 Folyóiratcikk Journal Article 24 12 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 2 2 2 2 2023 0 3 3 3 3 2024 0 3 3 3 3 2025 0 3 3 3 3 2026 0 1 1 1 1 D1 false 10027489,10000223 false false false 2022-01-26T12:26:37.145+0000 Biofizikai Intézet (HRN SZBK); Biokémiai és Orvosi Kémiai Intézet (PTE / ÁOK); Központi Laboratóriumok (HRN SZBK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Intézet (SE / AOK / I) 7 42 5 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 99214178 /api/authorship/99214178 1 0.143 true false false Author 10034830 /api/author/10034830 Kaucsár Tamás true 10034830 true Kaucsár Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99214179 /api/authorship/99214179 2 0.143 false false false Author 10061092 /api/author/10061092 Róka Beáta true 10061092 true Róka Beáta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99214180 /api/authorship/99214180 3 0.14285715 false false false Author 10054736 /api/author/10054736 Tod Pál true 10054736 true Tod Pál true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99214181 /api/authorship/99214181 4 0.143 false false false Author 10076177 /api/author/10076177 Do Thanh Phuong true true Do Phuong Thanh true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99214182 /api/authorship/99214182 5 0.143 false false false Author 10025007 /api/author/10025007 Hegedűs Zoltán true 10025007 true Hegedűs Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99214183 /api/authorship/99214183 6 0.143 false true false Author 10027489 /api/author/10027489 Szénási Gábor true 10027489 true Szénási Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 99214184 /api/authorship/99214184 7 0.143 false true true Author 10000223 /api/author/10000223 Hamar Péter true 10000223 true Hamar Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 20129786 /api/publicationidentifier/20129786 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s11357-021-00460-9 https://doi.org/10.1007/s11357-021-00460-9 false true PublicationIdentifier 20136686 /api/publicationidentifier/20136686 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000710871800001 https://www.webofscience.com/wos/woscc/full-record/000710871800001 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true 17 true IDENTICAL 34697716 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34697716&dopt=Abstract false true Keyword 18949 /api/keyword/18949 true 18949 true Keyword 1076329 /api/keyword/1076329 true 1076329 true Keyword 1388558 /api/keyword/1388558 true 1388558 true SjrRating 11312161 /api/sjrrating/11312161 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2707 /api/classificationexternal/2707 true 2707 true D1 DIRECT true true /api/publication/32470555 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10034830"><a href="/gui2/?type=authors&mode=browse&sel=10034830" target="_blank">Kaucsár Tamás (<span class="authorship-author-name">Kaucsár Tamás</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061092"><a href="/gui2/?type=authors&mode=browse&sel=10061092" target="_blank">Róka Beáta (<span class="authorship-author-name">Róka Beáta</span> <span class="authorAux-mtmt"> Vese Kórélettana</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054736"><a href="/gui2/?type=authors&mode=browse&sel=10054736" target="_blank">Tod Pál (<span class="authorship-author-name">Tod Pál</span> <span class="authorAux-mtmt"> Purinerg jelátviteli rendszer a központi idegre...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076177"><a href="/gui2/?type=authors&mode=browse&sel=10076177" target="_blank">Do Phuong Thanh (<span class="authorship-author-name">Do Thanh Phuong</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025007"><a href="/gui2/?type=authors&mode=browse&sel=10025007" target="_blank">Hegedűs Zoltán (<span class="authorship-author-name">Hegedűs Zoltán</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biofizikai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai és Orvosi Kémiai Intézet; <span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027489"><a href="/gui2/?type=authors&mode=browse&sel=10027489" target="_blank">Szénási Gábor<sup>**</sup> (<span class="authorship-author-name">Szénási Gábor</span> <span class="authorAux-mtmt"> kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000223"><a href="/gui2/?type=authors&mode=browse&sel=10000223" target="_blank">Hamar Péter ✉ (<span class="authorship-author-name">Hamar Péter</span> <span class="authorAux-mtmt"> Vese immunológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32470555" target="_blank">Divergent regulation of lncRNA expression by ischemia in adult and aging mice.</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">44</span> <span class="journal-issue">1</span> <span class="page"> pp 429-445 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-021-00460-9" target="_blank" href="https://doi.org/10.1007/s11357-021-00460-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000710871800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000710871800001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="159184" target="_blank" href="https://real.mtak.hu/159184"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85117894164" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85117894164"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34697716" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34697716&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 12</span> | Független: 12 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;12 | DOI jelölt:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32470555&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32470555</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (17-4-I-SE-79) Támogató: ÚNKP, GINOP - STAY ALIVE(GINOP-2.3.2-15-2016-00048) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, Hungarian Research FundOrszagos Tudomanyos Kutatasi Alapprogramok(OTKA SNN-114619), (ANN-110810) Támogató: OTKA, (NVKP_16-1-2016-0042) Támogató: OTKA, (300021 Pécsi Egyetem Kispál Gyula pályázat) </div> <div class="lastModified">Utolsó módosítás: 2023.09.02. 15:43 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>